Protein Alignment DHX15 and l(2)37Cb

DIOPT Version :10

• Sequence 1: NP_001349.2
• Gene: DHX15 / 1665
• HGNCID: 2738
• Length: 795
• Species: Homo sapiens
• Sequence 2: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Alignment Length: 641
• Identity: 344/641 - (53%)
• Similarity: 448/641 - (69%)
• Gaps: 27/641 - (4%)

Human   134 RLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAA 198
            |..|||:.:|:.....:..||..::.||||||||||:||:.||  ......|:.:.|||||||||
  Fly   249 RRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQYLVE--AGFTKDKKMIGCTQPRRVAA 311

Human   199 MSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAH 263
            ||||.|||:||.|.||.|||||||||||:|.:|||||||||.|.||.:::|.|..|.|:|:||||
  Fly   312 MSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDGTLHREFLSEPDLASYSVMIIDEAH 376

Human   264 ERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPE 328
            ||||.||||.|::|::.|.|.:||:::.||||||.||..:||:.|:..||||.:||:||||..||
  Fly   377 ERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFFDDAPIFRIPGRRYPVDIFYTKAPE 441

Human   329 RDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACK-----RIKREVDDLGPEVGDIKIIPL 388
            .||::|...:|:||| ..:..||:|:|||||:|| |.|:     |:||    ||.::.::.:||:
  Fly   442 ADYIDACCVSVLQIH-ATQPLGDILVFLTGQDEI-ETCQEVLHDRVKR----LGSKIRELIVIPV 500

Human   389 YSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRV 453
            |:.||...|.:||||.||.      .|||:::|||||||||||.:::|||||||||..:|.|..:
  Fly   501 YANLPSDMQAKIFEPTPPN------ARKVILATNIAETSLTIDNIIYVIDPGFAKQNNFNSRTGM 559

Human   454 ESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLG 518
            |||:|..||||||.|||||||||.|||||||||..|||.|::|||.|||.|.|||:.||.||.||
  Fly   560 ESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRINLGNAVLMLKALG 624

Human   519 IDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNC 583
            |:||:||||:|||..|||:.|||.|..|.|||..|:||:||..|||||:||.:.||::||..|.|
  Fly   625 INDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMMGKMLLASEKYKC 689

Human   584 SNEVLSITAMLSVPQC-FVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDN 647
            |.|:::|.|||||... |.||.:....||.|:..|.|:.||||:||.||:.:.:...|.||||:|
  Fly   690 SEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWAETDYSTQWCYEN 754

Human   648 FINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTS-RDYYINIRKALVTGYFMQVAHLERTGHYL 711
            ||.|||:..|.:||:||..:|.|..:     |..| ....:|:|||...|||..||.|.:.|||.
  Fly   755 FIQYRSMKRARDVREQLVGLMQRVEI-----DMVSCLPETVNVRKAATAGYFYHVARLSKGGHYK 814

Human   712 TVKDNQVVQLHP-STVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYY 766
            |:|.||.|.:|| |::.:..|.||||:|.|.|:|.|:|...:|:.:||:::||.||
  Fly   815 TIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYY 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108
		HrpA	136..>763	CDD:441249	339/634 (53%)
		DEAH box	260..263		2/2 (100%)
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	5/17 (29%)
		HrpA	251..>868	CDD:441249	340/635 (54%)