Protein Alignment DHX15 and CG1582

DIOPT Version :10

• Sequence 1: NP_001349.2
• Gene: DHX15 / 1665
• HGNCID: 2738
• Length: 795
• Species: Homo sapiens
• Sequence 2: NP_572663.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 828
• Identity: 243/828 - (29%)
• Similarity: 380/828 - (45%)
• Gaps: 170/828 - (20%)

Human    75 PPLKASHSAHSTHSAHSTHSTHSAHSTHAGHAGHTSLP-----QCINPFTNLPHTPRYYDILKKR 134
            |..:...|...:|.|....|.:.     .||..:....     :.:..|.......||..|:..|
  Fly   391 PDAEHHQSPKPSHYARGQTSRND-----GGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGR 450

Human   135 LQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVE--YMRSLPGPKR------GVACT 191
            .|||.:...:|...::......|:.||||.||:||:||:.::  :.|:|..|.:      .:.||
  Fly   451 KQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICT 515

Human   192 QPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGV 256
            ||||::|:.||:|||.|....:||.|||.||.|:..|..|.|.:.|.|:|||...:||||.....
  Fly   516 QPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTH 580

Human   257 IILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPV-E 320
            :|:||.|||:..:|.|:.:||.::|:|.|||||:|||||:|..|..||...|:|.|||||.|| :
  Fly   581 VIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQ 645

Human   321 IF--------------------------------------------------------------- 322
            :|
  Fly   646 LFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQR 710

Human   323 ------------YTPEP---ERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKRE 372
                        |..||   ..:.:|:.::.:::.......||.:|:||.|..||......:
  Fly   711 YAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSL--- 772

Human   373 VDD--LGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVF 435
            :|:  ..|..|...::||:|.|..:.|..:|:..||.|      ||:|:||||||||:|||..||
  Fly   773 LDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGK------RKIVLSTNIAETSVTIDDCVF 831

Human   436 VIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYP 500
            |:|.|..|:|.::....:|||.:..:|:|:|:||.|||||..||.|..|||...|:..:.....|
  Fly   832 VVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVP 896

Human   501 EILRSNLGSVVLQLKKL----GIDDL-VHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGS 560
            ||.|..|..:||::|.|    ..:.| |..:.::.|..::::.||..|..:.||:.:..||.||.
  Fly   897 EIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGH 961

Human   561 MMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHL 625
            .:|..|:|.::.|:::....:.|.:.||:|.|.||....||.|...:..||:.|..||..:.|||
  Fly   962 HLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHL 1026

Human   626 TLLNVY-----------HAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDR-----FNLP 674
            |:||.|           :|..:|:.|     ::|::..:|.:..:::.|...::..     .::|
  Fly  1027 TVLNAYRKWLDVARRGNYAASRNYAS-----EHFLSLNTLETIADLKYQYLELLVSIGFVPIDVP 1086

Human   675 RRS-------------------------TDFTSRDYYINIRKALVTG-YFMQVA----HLERTGH 709
            ||.                         |.......|.||.|.:... .::|.|    ..|.:.|
  Fly  1087 RRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHH 1151

Human   710 YLTVK--DNQVVQLHPSTVLDH----KPEWVLYNEFVLTTKNYIRTCT 751
            .|..|  .:..|::|||:|...    :..::::.|.|.|:..|||.|:
  Fly  1152 DLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCS 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108		7/32 (22%)
		HrpA	136..>763	CDD:441249	231/762 (30%)
		DEAH box	260..263		2/2 (100%)
CG1582	NP_572663.1	UBA_like_SF	123..154	CDD:473871
		RWD_DHX57	175..367	CDD:467661
		zf-CCCH	245..272	CDD:459885
		HrpA	452..>1075	CDD:441249	205/636 (32%)
		OB_NTP_bind	1114..1212	CDD:400182	23/86 (27%)