Protein Alignment Kpna1 and Kap-alpha3

DIOPT Version :10

• Sequence 1: NP_032491.2
• Gene: Kpna1 / 16646
• MGIID: 103560
• Length: 538
• Species: Mus musculus
• Sequence 2: NP_731377.1
• Gene: Kap-alpha3 / 41158
• FlyBaseID: FBgn0027338
• Length: 514
• Species: Drosophila melanogaster
• Alignment Length: 518
• Identity: 240/518 - (46%)
• Similarity: 332/518 - (64%)
• Gaps: 22/518 - (4%)

Mouse     7 ENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQ 71
            |..||:::|||..:.|||||||.|..::|||.||||.:.|||||...:..|:||        |..
  Fly     5 EQNRLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNLDSNTDEE--------EQL 61

Mouse    72 INNMEMAPGGVITSDMTDMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLK 136
            .:::::.......:|.|      .|||||:|.|..|||||.:.||||:::|.: .::...||.||
  Fly    62 SSSIDLKKLAKAAADAT------KPEQQLAAVQAARKLLSSDKNPPINDLIQS-DILPILVECLK 119

Mouse   137 RKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDST 201
            :..:..||||:||.|||||||.|.||..|:.|||||:|::||:|...:|.||||||||||.||..
  Fly   120 QHNHTMLQFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGP 184

Mouse   202 MCRDYVLNCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVS 266
            :.||:|:...::.|||........:|..||..|.:.||||.|.|.|..|.:...|..|:.|:..:
  Fly   185 LLRDFVIKHGVVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHT 249

Mouse   267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQT 331
            ||::|.|..||:|||:||.||:||.||::||..:|:.||.:::.||.:.|||||||||||.|.||
  Fly   250 DTNILVDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQT 314

Mouse   332 QVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRT 396
            ||:||..||.....|||.|||.|:|||.|.:|||||||::|:|.||:..:.|.:|..|...||:|
  Fly   315 QVVLNYDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQT 379

Mouse   397 RKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRN 461
            :|||||||:|.|..|:.||:..|::.|.|.|.||||:..|.:::.|.|:||.|:|::.:
  Fly   380 QKEAAWAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVAD------ 438

Mouse   462 GSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQY 524
             |.:......|||..||.|||.||||||.|||:.|:::|:.||..|.|.:::||..|.:|..:
  Fly   439 -SHVEAVANCIEECEGLAKIERLQSHENVEIYKLAYEIIDQYFTDEGEQTNMAPTSDGAQYNF 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kpna1	NP_032491.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		18/33 (55%)
		SRP1	33..516	CDD:227396	223/482 (46%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P52293	42..51		5/8 (63%)
		ARM 1, truncated	77..117		15/39 (38%)
		ARM 2	118..161		20/42 (48%)
		armadillo repeat	128..154	CDD:293788	12/25 (48%)
		NLS binding site (major). /evidence=ECO:0000250|UniProtKB:P52293	149..241		46/91 (51%)
		armadillo repeat	162..198	CDD:293788	22/35 (63%)
		armadillo repeat	204..239	CDD:293788	10/34 (29%)
		ARM 4	207..245		13/37 (35%)
		Binding to RAG1. /evidence=ECO:0000250|UniProtKB:P52294	245..437		98/191 (51%)
		armadillo repeat	256..281	CDD:293788	10/24 (42%)
		armadillo repeat	289..325	CDD:293788	19/35 (54%)
		NLS binding site (minor). /evidence=ECO:0000250|UniProtKB:P52293	318..406		53/87 (61%)
		armadillo repeat	373..409	CDD:293788	17/35 (49%)
		ARM 9	413..457		17/43 (40%)
		armadillo repeat	416..450	CDD:293788	13/33 (39%)
		ARM 10, atypical	460..504		20/43 (47%)
Kap-alpha3	NP_731377.1	SRP1	8..500	CDD:227396	239/513 (47%)
		armadillo repeat	104..137	CDD:293788	13/33 (39%)
		armadillo repeat	145..181	CDD:293788	22/35 (63%)
		armadillo repeat	187..222	CDD:293788	10/34 (29%)
		armadillo repeat	239..264	CDD:293788	10/24 (42%)
		armadillo repeat	272..308	CDD:293788	19/35 (54%)
		armadillo repeat	314..348	CDD:293788	19/33 (58%)
		armadillo repeat	356..390	CDD:293788	16/33 (48%)
		armadillo repeat	399..433	CDD:293788	13/33 (39%)