DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kpna1 and Kap-alpha3

DIOPT Version :9

Sequence 1:	NP_032491.2	Gene:	Kpna1 / 16646	MGIID:	103560	Length:	538	Species:	Mus musculus
Sequence 2:	NP_001163572.1	Gene:	Kap-alpha3 / 41158	FlyBaseID:	FBgn0027338	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	240/518 - (46%)
Similarity:	332/518 - (64%)	Gaps:	22/518 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 ENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQ 71
            |..||:::|||..:.|||||||.|..::|||.||||.:.|||||...:..|:||        |..
  Fly     5 EQNRLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNLDSNTDEE--------EQL 61

Mouse    72 INNMEMAPGGVITSDMTDMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLK 136
            .:::::.......:|.|      .|||||:|.|..|||||.:.||||:::|.: .::...||.||
  Fly    62 SSSIDLKKLAKAAADAT------KPEQQLAAVQAARKLLSSDKNPPINDLIQS-DILPILVECLK 119

Mouse   137 RKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDST 201
            :..:..||||:||.|||||||.|.||..|:.|||||:|::||:|...:|.||||||||||.||..
  Fly   120 QHNHTMLQFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGP 184

Mouse   202 MCRDYVLNCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVS 266
            :.||:|:...::.|||........:|..||..|.:.||||.|.|.|..|.:...|..|:.|:..:
  Fly   185 LLRDFVIKHGVVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHT 249

Mouse   267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQT 331
            ||::|.|..||:|||:||.||:||.||::||..:|:.||.:::.||.:.|||||||||||.|.||
  Fly   250 DTNILVDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQT 314

Mouse   332 QVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRT 396
            ||:||..||.....|||.|||.|:|||.|.:|||||||::|:|.||:..:.|.:|..|...||:|
  Fly   315 QVVLNYDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQT 379

Mouse   397 RKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRN 461
            :|||||||:|.|..|:.||:..|::.|.|.|.||||:..|.:::.|.|:||.|:|::.:
  Fly   380 QKEAAWAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVAD------ 438

Mouse   462 GSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQY 524
             |.:......|||..||.|||.||||||.|||:.|:::|:.||..|.|.:::||..|.:|..:
  Fly   439 -SHVEAVANCIEECEGLAKIERLQSHENVEIYKLAYEIIDQYFTDEGEQTNMAPTSDGAQYNF 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kpna1	NP_032491.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		18/33 (55%)
		SRP1	33..516	CDD:227396	223/482 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	42..51		5/8 (63%)
		ARM 1, truncated	77..117		15/39 (38%)
		ARM 2	118..161		20/42 (48%)
		armadillo repeat	128..154	CDD:293788	12/25 (48%)
		NLS binding site (major). /evidence=ECO:0000250	149..241		46/91 (51%)
		armadillo repeat	162..198	CDD:293788	22/35 (63%)
		armadillo repeat	204..239	CDD:293788	10/34 (29%)
		ARM 4	207..245		13/37 (35%)
		Binding to RAG1. /evidence=ECO:0000250	245..437		98/191 (51%)
		armadillo repeat	256..281	CDD:293788	10/24 (42%)
		armadillo repeat	289..325	CDD:293788	19/35 (54%)
		NLS binding site (minor). /evidence=ECO:0000250	318..406		53/87 (61%)
		armadillo repeat	373..409	CDD:293788	17/35 (49%)
		ARM 9	413..457		17/43 (40%)
		armadillo repeat	416..450	CDD:293788	13/33 (39%)
		ARM 10, atypical	460..504		20/43 (47%)
Kap-alpha3	NP_001163572.1	IBB	7..88	CDD:280005	37/94 (39%)
		SRP1	8..500	CDD:227396	239/513 (47%)
		ARM	104..224	CDD:237987	56/120 (47%)
		armadillo repeat	104..137	CDD:293788	13/33 (39%)
		armadillo repeat	145..181	CDD:293788	22/35 (63%)
		armadillo repeat	187..222	CDD:293788	10/34 (29%)
		ARM	236..350	CDD:237987	61/113 (54%)
		armadillo repeat	239..264	CDD:293788	10/24 (42%)
		armadillo repeat	272..308	CDD:293788	19/35 (54%)
		armadillo repeat	314..348	CDD:293788	19/33 (58%)
		ARM	315..433	CDD:237987	59/117 (50%)
		armadillo repeat	356..390	CDD:293788	16/33 (48%)
		armadillo repeat	399..433	CDD:293788	13/33 (39%)
		Arm_3	442..485	CDD:292804	22/42 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2158
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860