DRSC/TRiP Functional Genomics Resources

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Protein Alignment PRICKLE2 and RGA1

DIOPT Version :10

Sequence 1:NP_942559.1 Gene:PRICKLE2 / 166336 HGNCID:20340 Length:844 Species:Homo sapiens
Sequence 2:NP_014770.1 Gene:RGA1 / 854294 SGDID:S000005653 Length:1007 Species:Saccharomyces cerevisiae


Alignment Length:659 Identity:131/659 - (19%)
Similarity:230/659 - (34%) Gaps:153/659 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   193 PRCAACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQR--YIMKEGRPYCCHCFESLYAEYC 255
            |.|..|.|.|......|.....||...|.|::||..|..:.  .::..|...|..|.:|     |
Yeast    11 PSCVRCKEFITTGHAYELGCDRWHTHCFACYKCEKPLSCESDFLVLGTGALICFDCSDS-----C 70

Human   256 DTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSD 320
            ..|.:.  ||...:.....:......||.|..|.:::....:...:..:||.             
Yeast    71 KNCGKK--IDDLAIILSSSNEAYCSDCFKCCKCGENIADLRYAKTKRGLFCL------------- 120

Human   321 SSDSAFQNARAK-----ESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVD---PLSLQMD 377
               |..:...||     |.:|..|  ||......|:::.....:||::.:..:..   |.||   
Yeast   121 ---SCHEKLLAKRKYYEEKKRRLK--KNLPSLPTPVIDNGHTDEVSASAVLPEKTFSRPASL--- 177

Human   378 MLSLSSQTPSLNRDPIWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMW 442
                      :|..|   |..||   ...:|.|.:......:      |.|:.....:|:  ..:
Yeast   178 ----------VNEIP---SGSEP---SKDIETNSSDIVPHFI------TGYNDSDDNSGS--SKF 218

Human   443 GKHFS----NPKRSSSLAMTGHAGSFIKECREDYYPGRLRSQESYSDMS-SQSFSETRGSIQVPK 502
            |.:.|    .|:.:|    |.|....:||          .::...::|| :.:...|....:.|.
Yeast   219 GSNVSIDVIGPEENS----TEHVNDDVKE----------EAEAPSANMSLNVATDPTLSCKEPPS 269

Human   503 YEEEEEEEGGL--STQQCRTRHPIS---------SLKYTEDMTPTEQTPRGSME----------S 546
            :......:..|  |:.|...:.|.|         ||:.::.:.|...:.|.:.|          |
Yeast   270 HSRNLLNKTPLRNSSGQYLAKSPSSYRQGIIVNDSLEESDQIDPPNNSSRNASELLTSVLHSPVS 334

Human   547 LALSNATGLSAD----GGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESV-- 605
            :.:.|..|.:.|    |...:.:       |.||:       :.|:|:....:::|....|.|  
Yeast   335 VNMKNPKGSNTDIFNTGEISQMD-------PSLSR-------KVLNNIVEETNALQRPVVEVVKE 385

Human   606 -RSLLSAQQYQEMEGNLHQLSNPIGYRDLQSHGRMHQSFDFDGGMAGSKLPGQE--GVRIQPMSE 667
             ||:......|:.:...:..||..|.....|.....:|.|....:. |:..|::  .|::.|.|:
Yeast   386 DRSVPDLAGVQQEQAEKYSYSNNSGKGRKISRSLSRRSKDLMINLK-SRATGKQDSNVKLSPASK 449

Human   668 RTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAIS--RLKDRPPLRAREDYDQFMRQR 730
            .|.||  |:|..|....|....:..|.|.:...|.:.:::::  |..|...||....     ::.
Yeast   450 VTSRR--SQDLMRDNDSHTGLDTPNSNSTSLDILVNNQKSLNYKRFTDNGTLRVTSG-----KET 507

Human   731 SFQESMGHG----SRRDLYGQCPRTVSDLALQN--------AFGDRWGPYFAEYD-----WCSTC 778
            :.:|...|.    |..|...|.|.|.|::::..        .|..|.|..::..:     |..|.
Yeast   508 ALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDRRNGSSYSNQNYSIPSWQKTP 572

Human   779 SSSSE-SDN 786
            .:..| |||
Yeast   573 KTQLENSDN 581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PRICKLE2NP_942559.1 PET_Prickle 26..122 CDD:193602
LIM1_Prickle 130..188 CDD:188799
LIM2_Prickle 193..248 CDD:188802 16/56 (29%)
LIM3_Prickle 253..311 CDD:188804 10/57 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 314..350 8/40 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..519 7/40 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..709 17/71 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..844
RGA1NP_014770.1 LIM1_Rga 13..67 CDD:188780 14/53 (26%)
LIM2_Rga 70..123 CDD:188781 11/70 (16%)
RhoGAP 803..1002 CDD:214618
Blue background indicates that the domain is not in the aligned region.

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