Protein Alignment PRICKLE2 and RGA2

DIOPT Version :10

• Sequence 1: NP_942559.1
• Gene: PRICKLE2 / 166336
• HGNCID: 20340
• Length: 844
• Species: Homo sapiens
• Sequence 2: NP_010667.1
• Gene: RGA2 / 851985
• SGDID: S000002787
• Length: 1009
• Species: Saccharomyces cerevisiae
• Alignment Length: 902
• Identity: 168/902 - (18%)
• Similarity: 271/902 - (30%)
• Gaps: 337/902 - (37%)

Human   122 PVTMTGAICEQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELL-VDLIYFYQD-GKIYCG 184
            |:....::|.:|...|....:....|:.     ||..||.|..|::.| .|..:...| |.:.|
Yeast     5 PINDQSSLCVRCNKSIASSQVYELESKK-----WHDQCFTCYKCDKKLNADSDFLVLDIGTLIC- 63

Human   185 RHHAECLKPRCAACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIM-KEGRPYCCHCFE 248
               .:|             :|:||               .|...:.....|: .....||.:||.
Yeast    64 ---YDC-------------SDKCT---------------NCGDKIDDTAIILPSSNEAYCSNCFR 97

Human   249 SLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAG 313
                  |..|:..|         ....:..|:...||..|.:.||.:..|..:.|
Yeast    98 ------CCRCSNRI---------KNLKYAKTKRGLCCMDCHEKLLRKKQLLLENQ---------- 137

Human   314 EDPNGSDSSDSAFQNARAKESRRSAK--------IGKNKGKTEEPMLNQHSQLQVSSNRLSADVD 370
                   :.:|:.::...|...||.|        .||:...|        :...:|.|.:|::.|
Yeast   138 -------TKNSSKEDFPIKLPERSVKRPLSPTRINGKSDVST--------NNTAISKNLVSSNED 187

Human   371 PLSLQMDMLSLSSQTPSLNRDPIWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGA 435
            .......::|......|||         :.....|..::.:|.|..:.:|..:|..|..
Yeast   188 QQLTPQVLVSQERDESSLN---------DNNDNDNSKDREETSSHARTVSIDDILNSTL------ 237

Human   436 GAQPEMWGKHFSNPKRSSSLAMTGHAGSFIKECREDYYPGRLRSQESYSDM---------SSQSF 491
                    :|.||.....||.   ....:|.:..||.....|:.|.:..|.         :|.|.
Yeast   238 --------EHDSNSIEEQSLV---DNEDYINKMGEDVTYRLLKPQRANRDSIVVKDPRIPNSNSN 291

Human   492 SETRGSIQVPKYEEEE---------EEEGGLSTQQCRT---RHPISS---LKYTEDMTPTEQTPR 541
            :....||    |::||         |.|..::|.:..|   ..|::|   ::..|::.|    |.
Yeast   292 ANRFFSI----YDKEETDKDDTDNKENEIIVNTPRNSTDKITSPLNSPMAVQMNEEVEP----PH 348

Human   542 GSMESLALSNAT---GLSADG----GAKRQEHLSRFSMPDL--SKDSGMNVSEKLSNMGT----- 592
            |.  :|.||.||   ..|:.|    .:|...|:|..:..|.  .|.|..:.:.:||:.|:
Yeast   349 GL--ALTLSEATKENNKSSQGIQTSTSKSMNHVSPITRTDTVEMKTSTSSSTLRLSDNGSFSRPQ 411

Human   593 ------------------LNSSMQFRSAESVRSLLSAQQYQEM-------------EGNLHQ--- 623
                              |:.|...:|...|.:|.|  :..||             |.:.|.
Yeast   412 TADNLLPHKKVAPSPNKKLSRSFSLKSKNFVHNLKS--KTSEMLDPKHPHHSTSIQESDTHSGWG 474

Human   624 -------------LSNPIG--------YRDLQSHGRM------HQSFDFDGGMAGSKLPGQEGVR 661
                         ..||:.        |..|..||..      |:......|....|
Yeast   475 VSSTHTNIRKSKAKKNPVSRGQSDSTIYNTLPQHGNFTVPEFNHKKAQSSLGSISKK-------- 531

Human   662 IQPMSERTRRRATSRDDNRRF------------------------RP--------HRSRRSRRSR 694
                 :.:...||:|..|..|                        ||        |||...:.||
Yeast   532 -----QNSNDTATNRRINGSFTSSSSGHHIAMFRTPPLESGPLFKRPSLSSESAHHRSSSLQTSR 591

Human   695 SDNALHL-------ASEREAISRLKD---------RPPLRARE---------------------- 721
            |.|||..       |::..|.|..||         :..|..||
Yeast   592 STNALLEDDSTKVDATDESATSLEKDFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRLAKERL 656

Human   722 --DYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCSSSSES 784
              |.|...|::..|.:    |.|:...|.....:.:.::                    |.||.|
Yeast   657 LNDVDNLTREKDKQSA----SSRESLEQKENIATSITVK--------------------SPSSNS 697

Human   785 DNEGYFLGEPIPQPARLRYVTS--DELLHKYSSYGLPKSSTLGGRGQLHSRKRQKSK 839
            |.:| .:....|:|...:..:|  |..:....|.....:|:.||...:..::....|
Yeast   698 DRKG-SISNASPKPRFWKIFSSAKDHQVGDLESQQRSPNSSSGGTTNIAQKEISSPK 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE2	NP_942559.1	PET_Prickle	26..122	CDD:193602	168/902 (19%)
		LIM1_Prickle	130..188	CDD:188799	15/59 (25%)
		LIM2_Prickle	193..248	CDD:188802	8/55 (15%)
		LIM3_Prickle	253..311	CDD:188804	11/57 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..350		8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..519		11/55 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..709		21/114 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..844		4/18 (22%)
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780	16/75 (21%)
		LIM2_Rga	70..123	CDD:188781	14/82 (17%)
		RhoGAP	815..1002	CDD:214618