Protein Alignment PRICKLE2 and pk

DIOPT Version :10

• Sequence 1: NP_942559.1
• Gene: PRICKLE2 / 166336
• HGNCID: 20340
• Length: 844
• Species: Homo sapiens
• Sequence 2: NP_724538.1
• Gene: pk / 45343
• FlyBaseID: FBgn0003090
• Length: 1299
• Species: Drosophila melanogaster
• Alignment Length: 912
• Identity: 329/912 - (36%)
• Similarity: 435/912 - (47%)
• Gaps: 214/912 - (23%)

Human    19 DFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQLPPH 83
            |.||.|.||||||||||||.||||||:|:||..|:|.:|::||||||||||:.|::|||||||||
  Fly   516 DMQRQSHSDDDSGCALEEYTWVPPGLRPDQVRLYFSQIPDDKVPYVNSPGEQYRVRQLLHQLPPH 580

Human    84 DNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDIAVFASR 148
            |||||||:||.:||::||:|||:||||:.|||||||..   |:...|:.|...|:.|||||||:|
  Fly   581 DNEVRYCHSLTDEERKELRLFSTQRKRDALGRGNVRQL---MSARPCDGCDDLISTGDIAVFATR 642

Human   149 AGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGR 213
            .|....|||.||.|:||.|||||||||::||::||||||||.|||||:||||||.||||||||||
  Fly   643 LGPNASWHPACFACSVCRELLVDLIYFHRDGRMYCGRHHAETLKPRCSACDEIILADECTEAEGR 707

Human   214 HWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHA 278
            .|||.||.|.||:..||||||||:||:|||.|||::::|||||.|.:.||:|||||::|||||||
  Fly   708 AWHMNHFACHECDKQLGGQRYIMREGKPYCLHCFDAMFAEYCDYCGEAIGVDQGQMSHDGQHWHA 772

Human   279 TETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKIGKN 343
            |:.||.|..|:.|||||.|||::|.|:||.|||.||.|..||||.:.........::|
  Fly   773 TDECFSCNTCRCSLLGRAFLPRRGAIYCSIACSKGEPPTPSDSSGTGMYTTPTPPTQR------- 830

Human   344 KGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNRDPIWRSREEPYHYGN--- 405
                    :..|.|.            ||..::.....||..|       ...:::..|...
  Fly   831 --------VRPHPQA------------PLPARIPSSHASSSPP-------MSPQQQQQHQATFNQ 868

Human   406 ---KMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEM-WGKH--------FSNPKRSS---SL 455
               :|:..|.::...|:.|..   ||:.....||...:: .|.|        ||..:.||   :|
  Fly   869 AMYQMQSQQMEAAGGLVDQSK---SYAASDSDAGVVKDLEHGGHMGGGDLTDFSGGRASSTSQNL 930

Human   456 AMTGHAGSFIKECREDYYPGRLRSQE----SYSDMSS-----------QSFSETRGSIQVPKYEE 505
            :.....|.|    :..:.|..:..|.    ::::|||           .|:...|..::.|....
  Fly   931 SPLNSPGDF----QPHFLPKPMELQRDGVYNFNEMSSNLDAAWSAKPTNSYHLQRQLLENPHTAS 991

Human   506 EEEEEGGL-----STQQCRTRHPISSLKYTE----DMTPTEQTPRGSMESLALSN----ATGLSA 557
            ..|..|.|     ..|.....|.:||.::.:    |:......|.|.:..|...|    :|.|.
  Fly   992 MPELAGKLVAPPAHMQHLSQLHAVSSHQFQQHEYADILHPPPPPPGEIPELPTPNLSVASTALP- 1055

Human   558 DGGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSA-----ESVRSLLSAQQYQEM 617
                           |:|......:..::     :||:.|..:||     ..|..|..|.....|
  Fly  1056 ---------------PELMGSPTHSAGDR-----SLNTPMSTQSASHAPPHPVSILSGASSSSPM 1100

Human   618 EGNLHQLSNPIGYRDLQSHG---RMHQSFDFDGGMAGSKLPGQE-----------GVRIQPMSER 668
            .|      .|...:.::..|   .:.:|..:.|..||:...|:.           |......|.|
  Fly  1101 SG------EPAKKKGVRFEGIPDTLPRSRSYSGNGAGTSGGGERERDRDKDKEGGGRHGHGHSSR 1159

Human   669 TRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAISRLKDRPP----------------L 717
            .|||..|...:..   |||....||.|.......:..:.:|.....||                .
  Fly  1160 RRRRRKSSSSSSH---HRSGSGHRSHSTTRADTYAPAQPLSSSYQGPPSVLQAANLVHESPSRQQ 1221

Human   718 RAREDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCSSSS 782
            |.||      |:|..:||                                  .|.|.||||||||
  Fly  1222 RERE------REREREES----------------------------------EESDVCSTCSSSS 1246

Human   783 ESDNEGYFLGEPIPQ-----PARLRYVTSDELLHKYSSYGLPKSSTLGGRGQLHSRKRQKSKNCI 842
             |.:|.|.:...:||     ..|:.||.:|.|.:....    |.|.|||         .|.||||
  Fly  1247 -SSSEDYMMMYQLPQRRHYGGVRVSYVPNDALAYDRKR----KPSELGG---------DKDKNCI 1297

Human   843 IS 844
            ||
  Fly  1298 IS 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE2	NP_942559.1	PET_Prickle	26..122	CDD:193602	71/95 (75%)
		LIM1_Prickle	130..188	CDD:188799	36/57 (63%)
		LIM2_Prickle	193..248	CDD:188802	42/54 (78%)
		LIM3_Prickle	253..311	CDD:188804	37/57 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..350		7/35 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..519		10/57 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..709		18/80 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..844		9/21 (43%)
pk	NP_724538.1	PET_Prickle	523..618	CDD:193602	71/94 (76%)
		LIM1_Prickle	624..682	CDD:188799	36/57 (63%)
		LIM2_Prickle	687..742	CDD:188802	42/54 (78%)
		LIM3_Prickle	747..805	CDD:188804	37/57 (65%)