Protein Alignment PRICKLE2 and prickle2b

DIOPT Version :10

• Sequence 1: NP_942559.1
• Gene: PRICKLE2 / 166336
• HGNCID: 20340
• Length: 844
• Species: Homo sapiens
• Sequence 2: XP_068080220.1
• Gene: prickle2b / 368250
• ZFINID: ZDB-GENE-030724-6
• Length: 900
• Species: Danio rerio
• Alignment Length: 868
• Identity: 578/868 - (66%)
• Similarity: 671/868 - (77%)
• Gaps: 48/868 - (5%)

Human     1 MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVN 65
            :||.||||||||::|||:||||||||||||||||||||||||||||||||||||.|||:||||||
Zfish    57 VVTAMPLEMEKTVTKLMYDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSSLPEDKVPYVN 121

Human    66 SPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAIC 130
            |||||.|||||||||||||||||||||||:||||||||||:||||||||||||||||||||||||
Zfish   122 SPGEKYRIKQLLHQLPPHDNEVRYCNSLDDEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAIC 186

Human   131 EQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRC 195
            |||||||||||||||||||||||||||.||||::|:|||||||||||||||:|||||||.|||||
Zfish   187 EQCGGQINGGDIAVFASRAGHGVCWHPQCFVCSMCDELLVDLIYFYQDGKIFCGRHHAERLKPRC 251

Human   196 AACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQ 260
            :||||||.|||||||||||||||||||||||||||||||||||||||||.|||||||||||:|.:
Zfish   252 SACDEIILADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCTCFESLYAEYCDSCGE 316

Human   261 HIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSA 325
            ||||||||||||||||||||.||.||.||||||||||||||||||||||||.|:|.|||||||||
Zfish   317 HIGIDQGQMTYDGQHWHATEACFSCARCKKSLLGRPFLPKQGQIFCSRACSVGDDQNGSDSSDSA 381

Human   326 FQNARAKESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNR 390
            ||:||::|:|||:. ..||..|.....:.|...:.|:.|.||||||||||||:||||||||||||
Zfish   382 FQSARSREARRSSS-KSNKSSTGGSGGDGHQSGKASAMRFSADVDPLSLQMDLLSLSSQTPSLNR 445

Human   391 D-PIWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSY----SPGGQGAGAQPEMWGKHFSNP- 449
            : |.|:::.|.:.|..:.|  .:.:||.|||||||||||    |||             |.|:|
Zfish   446 ESPSWKTQAEMFGYEGRNE--LSTNPLHLLSQCNIRTSYSSNLSPG-------------HLSDPR 495

Human   450 -------KRSSSLAMTGHA--GSFIKECREDYYPGRLRSQESYSDMSSQSFSETRGSIQVPKYEE 505
                   ||....|:.|.:  .::.::..|||||..||:|.|::::...||.:.| |:.:..::.
Zfish   496 PKEPASSKRPPVSALKGKSLNENWFQQGPEDYYPPALRTQASFNEVPHNSFMDKR-SVSLHVFQR 559

Human   506 EEEEEGGLSTQQCRTRHPISSLKYTEDMTPTEQTPRGSMESLALSNATGLSADGGAKRQEHLSRF 570
            |:|::.|  .|..|:|:|||:|.::|.:||.||||||||||||||||||.|||||:|||||||||
Zfish   560 EKEKDVG--PQMSRSRNPISALGFSEQLTPLEQTPRGSMESLALSNATGTSADGGSKRQEHLSRF 622

Human   571 SMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPIGY-RDLQ 634
            |||||||||||||||| |||||||||:||.|:||:|||.|||.|.|:|..: |:..|:.| |:..
Zfish   623 SMPDLSKDSGMNVSEK-SNMGTLNSSVQFHSSESLRSLNSAQPYLELEAPV-QVRFPVQYPREPS 685

Human   635 SHGRMHQSFDFDGGMAGSKLPGQEGVRIQPMSERTRRRATSRDD-NRRFRPHRSRRSRRSRSDNA 698
            ....:...|.:......|.:......|:.|||||||||:...:: .||...||||||||||||||
Zfish   686 GINALPPGFAYQEEDRVSLVSNANNARLPPMSERTRRRSIDHEEPRRRHHHHRSRRSRRSRSDNA 750

Human   699 LHLASEREAISRLKDRPPLRAREDYDQFMRQRSFQESMGHGS-RRDLYGQCPRTVSDLALQN-AF 761
            |:|.:||....:   |..|.||||||||...|..:::.|.|. |:..:..||||.|||.||| |.
Zfish   751 LNLVAERRPAPK---RSQLHAREDYDQFPLPRGSRDTYGSGRLRQQPFRPCPRTTSDLTLQNPAL 812

Human   762 GDRWGPY-FAEY----DWCSTCSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGLPKS 821
            ....||| :.:|    ||||||||||||::||||||||||:|.:||::||:|||.||:|.||..|
Zfish   813 HRHQGPYSWDQYDYNDDWCSTCSSSSESEDEGYFLGEPIPRPIQLRHMTSEELLRKYNSSGLGAS 877

Human   822 STLGGRGQLHSRKRQKSKNCIIS 844
            ...|.|||||.|||:||||||||
Zfish   878 GQFGSRGQLHMRKRRKSKNCIIS 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE2	NP_942559.1	PET_Prickle	26..122	CDD:193602	90/95 (95%)
		LIM1_Prickle	130..188	CDD:188799	52/57 (91%)
		LIM2_Prickle	193..248	CDD:188802	51/54 (94%)
		LIM3_Prickle	253..311	CDD:188804	51/57 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..350		21/35 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..519		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..709		32/70 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..844		15/21 (71%)
prickle2b	XP_068080220.1	PET_Prickle	82..178	CDD:193602	90/95 (95%)
		LIM1_Prickle	186..244	CDD:188799	52/57 (91%)
		LIM2_Prickle	249..304	CDD:188802	51/54 (94%)
		LIM3_Prickle	309..367	CDD:188804	51/57 (89%)