Protein Alignment PRICKLE2 and Prickle2

DIOPT Version :10

• Sequence 1: NP_942559.1
• Gene: PRICKLE2 / 166336
• HGNCID: 20340
• Length: 844
• Species: Homo sapiens
• Sequence 2: XP_038963548.1
• Gene: Prickle2 / 312563
• RGDID: 1306723
• Length: 939
• Species: Rattus norvegicus
• Alignment Length: 847
• Identity: 804/847 - (94%)
• Similarity: 826/847 - (97%)
• Gaps: 3/847 - (0%)

Human     1 MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVN 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    93 MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVN 157

Human    66 SPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAIC 130
            ||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat   158 SPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAIC 222

Human   131 EQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRC 195
            |||||||.||||||||||||||:|||||||:||||||||||||||||||||||||||||||||||
  Rat   223 EQCGGQIKGGDIAVFASRAGHGICWHPPCFICTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRC 287

Human   196 AACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQ 260
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
  Rat   288 AACDEIIFADECTEAEGRHWHMRHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQ 352

Human   261 HIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSA 325
            ||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
  Rat   353 HIGIDQGQMTYDGQHWHATENCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSA 417

Human   326 FQNARAKESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNR 390
            ||||||||||||||||||||||||.|||||||||||||||||||||||:|||:||||||||||||
  Rat   418 FQNARAKESRRSAKIGKNKGKTEETMLNQHSQLQVSSNRLSADVDPLSVQMDLLSLSSQTPSLNR 482

Human   391 DPIWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSSSL 455
            |||||||:||:||||||||||:|||||||||||||||||||||.|||||:||.|||||||||||:
  Rat   483 DPIWRSRDEPFHYGNKMEQNQSQSPLQLLSQCNIRTSYSPGGQAAGAQPDMWAKHFSNPKRSSSM 547

Human   456 AMTGHAGSFIKECREDYYPGRLRSQESYSDMSSQSFSETRGSIQVPKY---EEEEEEEGGLSTQQ 517
            |:.||.||||:|||||||||||.||||||||||||||||||||.||||   |||||||||:||||
  Rat   548 ALKGHGGSFIQECREDYYPGRLMSQESYSDMSSQSFSETRGSIPVPKYEEEEEEEEEEGGISTQQ 612

Human   518 CRTRHPISSLKYTEDMTPTEQTPRGSMESLALSNATGLSADGGAKRQEHLSRFSMPDLSKDSGMN 582
            ||.|.|:|||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat   613 CRPRRPLSSLKYTEDMTPTEQTPRGSMESLALSNATGLSAEGGAKRQEHLSRFSMPDLSKDSGMN 677

Human   583 VSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPIGYRDLQSHGRMHQSFDFDG 647
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
  Rat   678 VSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPLGYRDLQSHGRMHQSFDFDG 742

Human   648 GMAGSKLPGQEGVRIQPMSERTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAISRLK 712
            |:|.|||||||||.|||||||||||.|||||||||||||||||||||||||||||||||.|:|||
  Rat   743 GIASSKLPGQEGVHIQPMSERTRRRTTSRDDNRRFRPHRSRRSRRSRSDNALHLASEREVIARLK 807

Human   713 DRPPLRAREDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCST 777
            ||||||||||||||:||||||||||.|||||||.||||||||||||||||:||||||.|||||||
  Rat   808 DRPPLRAREDYDQFVRQRSFQESMGQGSRRDLYSQCPRTVSDLALQNAFGERWGPYFTEYDWCST 872

Human   778 CSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGLPKSSTLGGRGQLHSRKRQKSKNCI 842
            ||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat   873 CSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGVPKSSTLGGRGQLHSRKRQKSKNCI 937

Human   843 IS 844
            ||
  Rat   938 IS 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE2	NP_942559.1	PET_Prickle	26..122	CDD:193602	94/95 (99%)
		LIM1_Prickle	130..188	CDD:188799	54/57 (95%)
		LIM2_Prickle	193..248	CDD:188802	53/54 (98%)
		LIM3_Prickle	253..311	CDD:188804	56/57 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..350		35/35 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..519		35/40 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..709		64/69 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..844		21/21 (100%)
Prickle2	XP_038963548.1	PET_Prickle	118..214	CDD:193602	94/95 (99%)
		LIM1_Prickle	222..280	CDD:188799	54/57 (95%)
		LIM2_Prickle	285..340	CDD:188802	53/54 (98%)
		LIM3_Prickle	345..403	CDD:188804	56/57 (98%)