Protein Alignment PRICKLE2 and Prickle2

DIOPT Version :10

• Sequence 1: NP_942559.1
• Gene: PRICKLE2 / 166336
• HGNCID: 20340
• Length: 844
• Species: Homo sapiens
• Sequence 2: NP_001391015.1
• Gene: Prickle2 / 243548
• MGIID: 1925144
• Length: 937
• Species: Mus musculus
• Alignment Length: 845
• Identity: 804/845 - (95%)
• Similarity: 827/845 - (97%)
• Gaps: 1/845 - (0%)

Human     1 MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVN 65
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse    93 MVTVMPLEMEKTISKLMFDFQRSSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVN 157

Human    66 SPGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAIC 130
            |.||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
Mouse   158 SAGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAIC 222

Human   131 EQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRC 195
            |||||||.||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   223 EQCGGQIKGGDIAVFASRAGHGICWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRC 287

Human   196 AACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQ 260
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   288 AACDEIIFADECTEAEGRHWHMRHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQ 352

Human   261 HIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSA 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   353 HIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSA 417

Human   326 FQNARAKESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNR 390
            ||||||||||||||||||||||||.|||||||||||||||||||||||:|||:||||||||||||
Mouse   418 FQNARAKESRRSAKIGKNKGKTEEAMLNQHSQLQVSSNRLSADVDPLSVQMDLLSLSSQTPSLNR 482

Human   391 DPIWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSSSL 455
            ||||||||||:||||||||||:|||||||||||||||||||||||||||:||.|||||||||||:
Mouse   483 DPIWRSREEPFHYGNKMEQNQSQSPLQLLSQCNIRTSYSPGGQGAGAQPDMWAKHFSNPKRSSSM 547

Human   456 AMTGHAGSFIKECREDYYPGRLRSQESYSDMSSQSFSETRGSIQVPKY-EEEEEEEGGLSTQQCR 519
            |:.||.||||:|||||||||||.|||||||||||||:||||||.|||| |||||||||:||||||
Mouse   548 ALKGHGGSFIQECREDYYPGRLMSQESYSDMSSQSFNETRGSIPVPKYEEEEEEEEGGISTQQCR 612

Human   520 TRHPISSLKYTEDMTPTEQTPRGSMESLALSNATGLSADGGAKRQEHLSRFSMPDLSKDSGMNVS 584
            .|.|:|||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   613 PRRPLSSLKYTEDMTPTEQTPRGSMESLALSNATGLSAEGGAKRQEHLSRFSMPDLSKDSGMNVS 677

Human   585 EKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPIGYRDLQSHGRMHQSFDFDGGM 649
            |||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||:
Mouse   678 EKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPLGYRDLQSHGRMHQSFDFDGGI 742

Human   650 AGSKLPGQEGVRIQPMSERTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAISRLKDR 714
            |.|||||||||.|||||||||||.|||||||||||||||||||||||||||||||||.|:|||:|
Mouse   743 ASSKLPGQEGVHIQPMSERTRRRTTSRDDNRRFRPHRSRRSRRSRSDNALHLASEREVIARLKER 807

Human   715 PPLRAREDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCS 779
            |||||||||||||||||||||:|.|||||||.||||||||||||||||:||||||.|||||||||
Mouse   808 PPLRAREDYDQFMRQRSFQESLGQGSRRDLYSQCPRTVSDLALQNAFGERWGPYFTEYDWCSTCS 872

Human   780 SSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGLPKSSTLGGRGQLHSRKRQKSKNCIIS 844
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   873 SSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGVPKSSTLGGRGQLHSRKRQKSKNCIIS 937

Human   845  844
            Mouse   938  937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE2	NP_942559.1	PET_Prickle	26..122	CDD:193602	93/95 (98%)
		LIM1_Prickle	130..188	CDD:188799	55/57 (96%)
		LIM2_Prickle	193..248	CDD:188802	53/54 (98%)
		LIM3_Prickle	253..311	CDD:188804	57/57 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..350		35/35 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..519		34/38 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..709		64/69 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..844		21/21 (100%)
Prickle2	NP_001391015.1	PET_Prickle	118..214	CDD:193602	93/95 (98%)
		LIM1_Prickle	222..280	CDD:188799	55/57 (96%)
		LIM2_Prickle	285..340	CDD:188802	53/54 (98%)
		LIM3_Prickle	345..403	CDD:188804	57/57 (100%)