Protein Alignment PRICKLE2 and prickle2

DIOPT Version :10

• Sequence 1: NP_942559.1
• Gene: PRICKLE2 / 166336
• HGNCID: 20340
• Length: 844
• Species: Homo sapiens
• Sequence 2: XP_031757102.1
• Gene: prickle2 / 100126208
• XenbaseID: XB-GENE-482891
• Length: 893
• Species: Xenopus tropicalis
• Alignment Length: 844
• Identity: 665/844 - (78%)
• Similarity: 749/844 - (88%)
• Gaps: 11/844 - (1%)

Human     3 TVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSP 67
            |.||||||||::|||||||||||||||||||||||||:|||||||||||||||||::||||||||
 Frog    59 TAMPLEMEKTMNKLMFDFQRNSTSDDDSGCALEEYAWIPPGLKPEQVHQYYSCLPDDKVPYVNSP 123

Human    68 GEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAICEQ 132
            |||.||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
 Frog   124 GEKSRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAICEQ 188

Human   133 CGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAA 197
            |||||||||:|||||||||||||||.||||.:|||||||||||||||||||||||||||||||||
 Frog   189 CGGQINGGDMAVFASRAGHGVCWHPQCFVCIICNELLVDLIYFYQDGKIYCGRHHAECLKPRCAA 253

Human   198 CDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHI 262
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
 Frog   254 CDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCNCFESLYAEYCDTCAQHI 318

Human   263 GIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQ 327
            ||||||||||||||||||.||||||||||||||||||||||||||||||.|||||||||||||||
 Frog   319 GIDQGQMTYDGQHWHATENCFCCAHCKKSLLGRPFLPKQGQIFCSRACSVGEDPNGSDSSDSAFQ 383

Human   328 NARAKESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNRDP 392
            |||||||||||||||||||.::..:||...|.|:||||||||||||||||:||:|||.||||||.
 Frog   384 NARAKESRRSAKIGKNKGKLDDGNMNQCGPLHVASNRLSADVDPLSLQMDLLSVSSQNPSLNRDQ 448

Human   393 IWRSREEPYHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSSSLAM 457
            :||||:|.||||||:|::|:||||||||||||||||:. ||||||||:||.|||:|.||  ||:|
 Frog   449 LWRSRDELYHYGNKIERSQSQSPLQLLSQCNIRTSYNT-GQGAGAQPDMWAKHFNNQKR--SLSM 510

Human   458 TGHAGSFIKECREDYYPGRLRSQESYSDMSSQSFSETRGSIQVPKYEEEEEEEGGLSTQQCRTRH 522
            .||:.||.:|.|||||.||:|.|||:||.|:.||:|.|.|::|||:||::.    ::.||||:||
 Frog   511 MGHSESFSQEGREDYYQGRVRQQESFSDASNHSFNEARSSLRVPKFEEKKP----MNPQQCRSRH 571

Human   523 PISSLKYTEDMTPTEQTPRGSMESLALSNATGLSADGGAKRQEHLSRFSMPDLSKDSGMNVSEKL 587
            ||::||:||.:|||||||||||||||||||||:|||||.||||||||||||||||||||||||||
 Frog   572 PINALKFTEGLTPTEQTPRGSMESLALSNATGVSADGGPKRQEHLSRFSMPDLSKDSGMNVSEKL 636

Human   588 SNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPIGYRDLQSHGRMHQSFDFDGGMAGS 652
            |||||||||.||||.|||||||||||||::..||..|:|...|||:..|.|:|..|.||.||:.:
 Frog   637 SNMGTLNSSSQFRSVESVRSLLSAQQYQDLAPNLSDLANSGKYRDVPPHSRLHHGFTFDAGMSMN 701

Human   653 KLPGQEGVRIQPMSERTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAISRLKDRPPL 717
            :|..|..:::.|||||||||..:||:::.:|.||.|||||||||||||||:|:  .:::|::|..
 Frog   702 ELTAQNNLKLTPMSERTRRRTQARDNDQHYRHHRQRRSRRSRSDNALHLATEQ--CNKIKEKPLA 764

Human   718 RAREDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCSSSS 782
            |.||:|::.|:||..::||....||::|.:..||.|||||||...||||.:..:|||||||||||
 Frog   765 RTREEYERLMQQRGVRDSMDQAVRREMYNRYQRTASDLALQNHLYDRWGQHVNDYDWCSTCSSSS 829

Human   783 ESDNEGYFLGEPIPQPARLRYVTSDELLHKYS--SYGLPKSSTLGGRGQLHSRKRQKSKNCIIS 844
            ||||||||||||||||.|||||||::|:|:|.  |.|:|||||||||||||||||:||||||||
 Frog   830 ESDNEGYFLGEPIPQPTRLRYVTSEDLIHQYGQCSGGIPKSSTLGGRGQLHSRKRRKSKNCIIS 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE2	NP_942559.1	PET_Prickle	26..122	CDD:193602	90/95 (95%)
		LIM1_Prickle	130..188	CDD:188799	53/57 (93%)
		LIM2_Prickle	193..248	CDD:188802	53/54 (98%)
		LIM3_Prickle	253..311	CDD:188804	56/57 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..350		33/35 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..519		17/37 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..709		38/69 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..844		20/21 (95%)
prickle2	XP_031757102.1	PET_Prickle	82..178	CDD:193602	90/95 (95%)
		LIM1_Prickle	186..244	CDD:188799	53/57 (93%)
		LIM2_Prickle	249..304	CDD:188802	53/54 (98%)
		LIM3_Prickle	309..367	CDD:188804	56/57 (98%)