DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DDX10 and CG5800

DIOPT Version :9

Sequence 1:	NP_004389.2	Gene:	DDX10 / 1662	HGNCID:	2735	Length:	875	Species:	Homo sapiens
Sequence 2:	NP_573230.1	Gene:	CG5800 / 32742	FlyBaseID:	FBgn0030855	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	920	Identity:	383/920 - (41%)
Similarity:	537/920 - (58%)	Gaps:	151/920 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     2 GKTAN--SPGSGARPDPVRSFNRWKKKHSHRQNKKKQLRKQLKKPEWQVERESISRLMQNYEKIN 64
            ||..:  .||||       :|...........|.:|:.|:::.|.........|..|...|.:|:
  Fly    10 GKPGSRFKPGSG-------TFKGAGGGRKSGDNSQKRPRQEINKSRLAATEAEIQDLKTKYAEID 67

Human    65 VNEITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLE 129
            ...|.:|:.|||||||.|.|.|:::...|::|:.:||.|||||||||||.||||||||||:||||
  Fly    68 ATAIKKFAQFPLSKKTQKALAESKFVHPTQVQRDSIGPALQGKDVLGAAITGSGKTLAFLIPVLE 132

Human   130 ALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNINIL 194
            .|:..:|:.|||:|.:|||||||||||.||.|:||||:||||||||||||:||.|..|::..|||
  Fly   133 HLFMNKWSRTDGVGAIIISPTRELAYQIFETLKKVGKHHDFSAGLIIGGKNLKFERTRMDQCNIL 197

Human   195 VCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKS 259
            :||||||||||||...|:.:.::|||||||||.|||||..|:|::|||.|..|||||||||||.:
  Fly   198 ICTPGRLLQHMDENPLFNTSTMEMLVLDEADRCLDMGFQKTLNSIIENFPPVRQTLLFSATQTNT 262

Human   260 VKDLARLSLKNPEYVWV-----HEKAKYST-----------PATLEQNYIVCELQQKISVLYSFL 308
            |:|||||:||:|.||..     .|:...||           |..|:|:|:|..|:.||::|:||:
  Fly   263 VQDLARLNLKDPVYVGYGGATPREEPSASTKKTPNTAVLAVPELLQQSYVVLNLEDKITMLWSFI 327

Human   309 RSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATD 373
            ::|||:|.|||.:|||:.:|||.:||:||||..:|||:|...|.||:.:|.:|:||...|:|:||
  Fly   328 KNHLKQKIIVFVASCKQAKYLYEIFCKLRPGSPLLALYGTLHQDRRIAIYEDFLRKSHVVMFSTD 392

Human   374 IAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEK-----AMVQQLLQK 433
            :|:|||||||||||:|.|||||.:.|||||||:||.|..||.||:|.|||:     |:.:||
  Fly   393 VASRGLDFPAVNWVVQLDCPEDVSQYIHRAGRSARNKTRGECLLVLTPSEEEYMISALKEQL--- 454

Human   434 KVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRSVYLMKDKEVFDVSKLPIPEY 498
            .:.::.::|:|:||...:.|:|:.|||..:|:..|||.|:||::||:||::|.:|:|..|.:..:
  Fly   455 NIDIRCVQIDPKKLFSPRVKIEAFLAQFPELRATAQRAFLSYIKSVFLMRNKRLFNVFSLDLDAF 519

Human   499 ALSLGLAVAPRVRFLQKM---QKQPTKELVRSQADKVIEPRAPSLTNDEVEEFRAYFNEKMSILQ 560
            |.||||||.|||.||:|.   |||..::..:....|.|.|....||
  Fly   520 AQSLGLAVTPRVPFLEKFLWRQKQLQQQKEQGDNAKSINPLLSKLT------------------- 565

Human   561 KGGKRLEGTEHRQDNDTGNEEQEEEEDDEEEMEEKLAKAKGSQAPSLPNTSEAQKIKEVPTQFLD 625
                       :|.:..|.:|.||..|||
  Fly   566 -----------KQQSFGGGDEDEENSDDE------------------------------------ 583

Human   626 RDEEEEDADFLKVKR--HNVFG----LDLKDEKTLQKKEPSKSSIKKKM-TKVAEAKKVMKRNFK 683
                    ||:||||  |:|.|    ||.:|:...:.:.|.....::|: ||.:.|||.:|:|.:
  Fly   584 --------DFIKVKRKDHDVEGEPVKLDEEDDTENEAEAPLVVPKREKLVTKASLAKKALKKNLQ 640

Human   684 VNKKITFTDEGELVQQWPQMQKSAI----KDAEEDDDTGGINLHKAKERLQEEDKFDKEEYRKKI 744
            ||.|:.|.||||.:.. .:.|..|:    :...:|||.|||||..:|..|.|||::||:.:|:.:
  Fly   641 VNSKLKFDDEGETMAD-DRSQMKALSARQRTVNQDDDDGGINLVLSKALLTEEDQYDKQRFRELV 704

Human   745 KAKHREKRLKEREARREANKRQAKAKDEEEAFLDWSDDDDDDDDG------FDPSTLPDPDK-YR 802
            |.:|:.:|.|.|:...|     ||..|:||   :..|||:.||.|      .|.|.|||||| |:
  Fly   705 KKRHKLQREKLRKKAEE-----AKGSDDEE---EQQDDDNADDAGSESDHSVDLSWLPDPDKVYK 761

Human   803 ----SSEDSDSEDMENKISDTKKKQGMKKRSNSEVEDVGPTSHNRKKARWDTLEPLDTGLSLAED 863
                :|:.::|:...:..||.:|...    |:.:.:||.......||::      |...::|.:.
  Fly   762 NKPNASDRNESKSESSDASDDEKADD----SDGDDDDVSDDEPAYKKSK------LTNKMTLMDT 816

Human   864 EELVLHLLRS 873
            |.:...||.|
  Fly   817 EAIAASLLGS 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DDX10	NP_004389.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		10/42 (24%)
		SrmB	50..518	CDD:223587	267/491 (54%)
		Q motif	69..97		12/27 (44%)
		DEADc	71..275	CDD:238167	137/203 (67%)
		DEAD box	222..225		2/2 (100%)
		HELICc	288..418	CDD:238034	75/129 (58%)
		DUF4217	450..509	CDD:290667	27/58 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..631		8/68 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	703..850		54/161 (34%)
CG5800	NP_573230.1	PRK01297	2..471	CDD:234938	245/470 (52%)
		DEADc	74..277	CDD:238167	136/202 (67%)
		HELICc	311..437	CDD:238034	73/125 (58%)
		DUF4217	474..530	CDD:290667	27/55 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145114
Domainoid	1	1.000	244	1.000	Domainoid score	I2208
eggNOG	1	0.900	-	-		E2759_KOG0343
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20922
Inparanoid	1	1.050	623	1.000	Inparanoid score	I873
Isobase	1	0.950	-	0	Normalized mean entropy	S1985
OMA	1	1.010	-	-		QHG46503
OrthoDB	1	1.010	-	-		D218522at33208
OrthoFinder	1	1.000	-	-		FOG0005116
OrthoInspector	1	1.000	-	-		oto90037
orthoMCL	1	0.900	-	-		OOG6_102138
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R291
SonicParanoid	1	1.000	-	-		X3635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750