DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DHX9 and bgcn

DIOPT Version :9

Sequence 1:	NP_001348.2	Gene:	DHX9 / 1660	HGNCID:	2750	Length:	1270	Species:	Homo sapiens
Sequence 2:	NP_523832.2	Gene:	bgcn / 47873	FlyBaseID:	FBgn0004581	Length:	1215	Species:	Drosophila melanogaster

Alignment Length:	914	Identity:	205/914 - (22%)
Similarity:	345/914 - (37%)	Gaps:	231/914 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   396 EILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDRAAECNIVVTQPRRISAVSVAERVAFE 460
            |||:::..:.|::...|....|:..:|..||||.  .::.:...|:..:.:.|.|...::|.|..
  Fly   156 EILQSLYASRVIVYNAALCWDKSVFLPLVILDDC--RNKKSNVKIMCIERQAILATYNSQRTANF 218

Human   461 RGEEPGKSCGYSVRFESILPRPHASIMFCTVGVLLRKLEA-GIRGISHVIVDEIHERDINTDFLL 524
            .||:.|::.|..:.:.|.: .....|::.|....||.|.: ..|.|||::|:::|..|..||.||
  Fly   219 FGEQLGETVGIQLPYFSAV-SSSTFIIYSTAQYFLRSLTSQQFRNISHLVVNDVHLHDPYTDILL 282

Human   525 VVLRDVVQAYPEVRIVLMSATIDTSMFCEYF--------FNCPIIEVYGRTYPVQEYFLEDCIQM 581
            ..:|..:.::..:|:||:|...:...|.::|        ...|  ||..|...:.|  |..||.:
  Fly   283 SEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQP--EVAPRVSYLNE--LHSCIAL 343

Human   582 THFVPPP---KDKKKKDKDDDGGEDDDANCNLICGDEYGPETRLS-------------------- 623
            ......|   |:..:..:.::...:....|....| |.|.:..|.
  Fly   344 AGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYG-ELGTDAALRPFLYAVNYDLAPVNYRHSLT 407

Human   624 -------MSQLNEKE----------TPF-------------------ELIEALLKY-IETLNVPG 651
                   .|:||:..          .|:                   |.|:.|..| :....|..
  Fly   408 GKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKS 472

Human   652 AVLVFLPGWNLIYTMQKHLEMNPHFGSHRYQ------ILPLHSQIPR------------------ 692
            |...|: .::||..:...|...|.:....|.      |||.:..|.:
  Fly   473 AKPDFV-DYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECS 536

Human   693 -----EEQRKVFDPVPVGVT----KVILSTNIAETSITINDVVYVID-SCKQKVKLFTAHNNMTN 747
                 :..|..:....|..:    ||:|:|:|.|:........|.|| :|:.        ||:
  Fly   537 IFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRL--------NNV-- 591

Human   748 YATV---------WASKTNLEQR----KGRAGRVRPGFCFHLCSRARFERLETHMTPEMFRTPLH 799
            |.|.         |.:|..|.:|    :...|.|:   ||.|.|:..:|.|.....|.:....|.
  Fly   592 YDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQ---CFRLISKEAYEELSETSQPSLQTMQLD 653

Human   800 EIALSIKLLRLGG-IGQFLAKAIEPPPLDAVIEAEHTLRELDALDANDELTPLGRILAKLPIEPR 863
            :|.|::|||.... |.::|...|.||||..|..|...|:::|.||..:::|.||..|..:|:..:
  Fly   654 KICLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQ 718

Human   864 FGKMMIMGCIFYVGDAICTIAAATCFPE----PFINEGKRLG-----YIHRN-------FAGNRF 912
            .|:|:|.|.:....|.|.||.::....:    ||..:...|.     ||..:       .:.|:|
  Fly   719 LGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQF 783

Human   913 SDHVALLSVFQAWDDARMGGEEAEIRFCEHKRLNMATLRMTWEAKVQ-LKEIL--INSGFPEDCL 974
            |||...:.:::.|.: ||           |.|.....|:..:|..:. |.|.|  |.|.......
  Fly   784 SDHFIFVRLYKEWQN-RM-----------HNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLR 836

Human   975 LTQVFTNTG--PDNNLD-------VVISLLAFGVYPNVCYHKEKRKILTTEGRNALIHKSSVNCP 1030
            ...:..:.|  ..|||:       :|.:.|..|:|||: |..:.|             |||:...
  Fly   837 AANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPNI-YAVDTR-------------KSSLKSA 887

Human  1031 FSSQDMKYPS--------PFFVFGEKIRTRAISAKGM-------TLVTPLQLLLFA--------- 1071
            ||.....:|:        |..:..:..||..|.....       |||.||.:.:|:
  Fly   888 FSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNRQKSHIVYATLVVPLAVAMFSGHPRIRLSP 952

Human  1072 ---SKKVQSDGQI-VLVDDWIKLQISHEAAACITGLRAAMEALVVEVTKQPAIISQLD------- 1125
               |:...:|..: |.:|:||.:.:|...|..:...|.....:..::.|.   .|:||
  Fly   953 ICDSEMSLTDRNVNVFIDEWIWMVMSKATAEMVMRTRYYFFKMYHDLLKH---CSELDMWRRDCE 1014

Human  1126 PVNE 1129
            ||::
  Fly  1015 PVSQ 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DHX9	NP_001348.2	Interaction with CREBBP. /evidence=ECO:0000269\|PubMed:9323138	1..250
		DSRM	5..69	CDD:214634
		siRNA-binding. /evidence=ECO:0000269\|PubMed:23361462, ECO:0007744\|PDB:3VYY	5..9
		siRNA-binding. /evidence=ECO:0000269\|PubMed:23361462, ECO:0007744\|PDB:3VYY	53..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..118
		DSRM	181..251	CDD:214634
		siRNA-binding. /evidence=ECO:0000269\|PubMed:23361462, ECO:0007744\|PDB:3VYX	182..186
		Interaction with BRCA1. /evidence=ECO:0000269\|PubMed:9662397	230..325
		siRNA-binding. /evidence=ECO:0000305\|PubMed:23361462	234..236
		Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000269\|PubMed:9323138	255..664		71/336 (21%)
		Necessary for interaction with H2AX. /evidence=ECO:0000269\|PubMed:15613478	313..952		156/688 (23%)
		MTAD. /evidence=ECO:0000269\|PubMed:11416126	331..380
		HrpA	381..1095	CDD:224557	197/871 (23%)
		Core helicase. /evidence=ECO:0000305\|PubMed:25062910	398..809		111/526 (21%)
		DEIH box	511..514		0/2 (0%)
		Nuclear localization signal (NLS1). /evidence=ECO:0000255	586..595		2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..608		2/22 (9%)
		HA2. /evidence=ECO:0000269\|PubMed:25062910	831..919		28/103 (27%)
		OB-fold. /evidence=ECO:0000269\|PubMed:20696886, ECO:0000269\|PubMed:25062910, ECO:0000269\|PubMed:25149208	958..1074		34/154 (22%)
		RGG. /evidence=ECO:0000269\|PubMed:10207077, ECO:0000269\|PubMed:25062910, ECO:0000269\|PubMed:25149208, ECO:0000269\|PubMed:9111062	1150..1270
		Nuclear localization signal (NLS2). /evidence=ECO:0000269\|PubMed:16375861	1155..1173
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1229..1248
bgcn	NP_523832.2	ANK repeat	406..438	CDD:293786	4/31 (13%)
		ANK	407..>460	CDD:238125	6/52 (12%)
		Ank_2	413..>460	CDD:289560	6/46 (13%)
		HrpA	<484..973	CDD:224557	122/527 (23%)
		HA2	694..763	CDD:214852	19/68 (28%)
		OB_NTP_bind	823..945	CDD:285018	31/135 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810