DRSC/TRiP Functional Genomics Resources

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Protein Alignment DHX9 and spn-E

DIOPT Version :10

Sequence 1:NP_001348.2 Gene:DHX9 / 1660 HGNCID:2750 Length:1270 Species:Homo sapiens
Sequence 2:NP_476741.1 Gene:spn-E / 41919 FlyBaseID:FBgn0003483 Length:1434 Species:Drosophila melanogaster


Alignment Length:778 Identity:242/778 - (31%)
Similarity:384/778 - (49%) Gaps:126/778 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   370 YQLEQDHDLQAILQERELLPVKKFESEILEAISQNSVVIIRGATGCGKTTQVPQFILDDFIQNDR 434
            :.|.:|.:| :|..:||         |||.||:.:.||||:|.|||||||||||:|||:..::.:
  Fly   107 FNLNRDKNL-SIYAKRE---------EILAAINAHPVVIIKGETGCGKTTQVPQYILDEAYKSGK 161

Human   435 AAECNIVVTQPRRISAVSVAERVAFERGEEPGKSCGYSVRFESILPRPHA----SIMFCTVGVLL 495
              .|||||||||||:|:|:|.||..||..:....|.:.|.    |.||::    .:::||.||||
  Fly   162 --YCNIVVTQPRRIAAISIANRVCQEREWQQNTVCSFQVG----LHRPNSLEDTRLLYCTTGVLL 220

Human   496 RKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYP-EVRIVLMSATIDTSMFCEYFFN 557
            ..|  ...:...:|:::||:||||.|.||||:|:|.::.... .|:|:|||||||.....:||..
  Fly   221 NNLINNKTLTHYTHIVLDEVHERDQNMDFLLIVVRRLLATNSRHVKIILMSATIDAKELSDYFTT 285

Human   558 C----PIIEV-YGRTYPVQEYFLEDCIQMTHFVPPPKDKKKKDKDDDGGEDDDANCNLICGDEYG 617
            .    |:|.. :.|.:.:::::.:   |:...:         ..::|.|.......|     ::|
  Fly   286 TNSIPPVITTNHRRKHSIEKFYRD---QLGSII---------WNEEDVGHQQVPEIN-----KHG 333

Human   618 PETRLSMSQLNEKETPFELIEALLKYIETLNVPGAVLVFLPGWNLIYTMQKH----LEMNPHFGS 678
            ....:.:..:.:.......|::...|.|.|.. ||||:||||...|.||.::    ||.:|:.  
  Fly   334 YRAAVKIIVIIDNMERKAAIQSRQSYDEALRY-GAVLIFLPGIYEIDTMAENLTCMLENDPNI-- 395

Human   679 HRYQILPLHSQIPREEQRKVFDPVPVGVTKVILSTNIAETSITINDVVYVIDSCKQKVKLFTAHN 743
             :..|:...|.:..|.||.||:|.|.|..|:||:|||||:|||:.||.||||.|..|||:....:
  Fly   396 -KVSIVRCFSLMTPENQRDVFNPPPPGFRKIILTTNIAESSITVPDVSYVIDFCLAKVKVTDTAS 459

Human   744 NMTNYATVWASKTNLEQRKGRAGRVRPGFCFHLCSRARFER-LETHMTPEMFRTPLHEIALSIKL 807
            :.::....||||.|..||.||.||:|.|..:.:.::..::| :.....|||.|.||....|..|:
  Fly   460 SFSSLRLTWASKANCRQRAGRVGRLRSGRVYRMVNKHFYQREMPEFGIPEMLRLPLQNSVLKAKV 524

Human   808 LRLGGIGQFLAKAIEPPPLDAVIEAEHTLRELDAL--------DAND-ELTPLGRILAKLPIEPR 863
            |.:|...:.||.|:.||.|..:......|:|:.||        |..| :||..|.|:::||::.|
  Fly   525 LNMGSPVEILALALSPPNLSDIHNTILLLKEVGALYLTVDGIYDPLDGDLTYWGTIMSRLPLDTR 589

Human   864 FGKMMIMGCIFYVGDAICTIAAATCFPEPFINEGKR--LG---YIHRNFAGNRFSDHVALLSVFQ 923
            ..:::|:|.||.:.:....|||....|..|.:||.|  ||   ::|..|:....||.||:..|:.
  Fly   590 QSRLIILGYIFNMLEEAIIIAAGLSTPGLFAHEGGRSQLGDSFWMHYIFSDGSGSDLVAIWRVYL 654

Human   924 AWDDARMGG--EEAEIRFCEHKRLNMATLRMTWEAKVQLKEILINS------GFPEDCLLTQVFT 980
            .:.:....|  :|:.||:.:...:::.:|:   |..:.::|:.:..      .||          
  Fly   655 TYLNIVENGHDQESAIRWAKRFHVSLRSLK---EIHLLVQELRVRCTHLGLIPFP---------- 706

Human   981 NTGPDNNLD-----VVISLLAFGV-YPNVCYHKEKRKILTTEGRNALIHKSSVNCPFSSQDMKYP 1039
             ..|:..:|     :::.::..|. |||  |....::......|| :....|.:.|..:......
  Fly   707 -VNPNQMMDDREKAIMLKVIIAGAFYPN--YFTRSKESCADTDRN-IYQTISGHDPCRTVYFTNF 767

Human  1040 SPFFVFGEKIRTRAISAKGMTLVTPLQLLLFASKKV---------QSDGQIVLV----DDWIK 1089
            .|.:: || :.||.|..            ||...::         |...|.|.|    ||||:
  Fly   768 KPAYM-GE-LYTRRIKE------------LFQEVRIPPENMDVTFQEGSQKVFVTFKQDDWIE 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DHX9NP_001348.2 Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9323138 1..250
DSRM_DHX9_rpt1 3..71 CDD:380683
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 5..9
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYY 53..55
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..118
DSRM_DHX9_rpt2 178..252 CDD:380684
siRNA-binding. /evidence=ECO:0000269|PubMed:23361462, ECO:0007744|PDB:3VYX 182..186
Interaction with BRCA1. /evidence=ECO:0000269|PubMed:9662397 230..325
siRNA-binding. /evidence=ECO:0000305|PubMed:23361462 234..236
Necessary for interaction with RNA polymerase II holoenzyme. /evidence=ECO:0000269|PubMed:9323138 255..664 105/305 (34%)
Necessary for interaction with H2AX. /evidence=ECO:0000269|PubMed:15613478 313..952 211/614 (34%)
DEXHc_DHX9 330..563 CDD:350730 87/203 (43%)
MTAD. /evidence=ECO:0000269|PubMed:11416126 331..380 3/9 (33%)
HrpA 388..>886 CDD:441249 185/523 (35%)
Core helicase. /evidence=ECO:0000305|PubMed:25062910 398..809 156/427 (37%)
DEIH box 511..514 2/2 (100%)
Nuclear localization signal (NLS1). /evidence=ECO:0000255 586..595 0/8 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..608 2/19 (11%)
HA2. /evidence=ECO:0000269|PubMed:25062910 831..919 33/101 (33%)
OB-fold. /evidence=ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208 958..1074 22/127 (17%)
OB_NTP_bind 994..1073 CDD:400182 17/79 (22%)
RGG. /evidence=ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:25062910, ECO:0000269|PubMed:25149208, ECO:0000269|PubMed:9111062 1150..1270
Nuclear localization signal (NLS2). /evidence=ECO:0000269|PubMed:16375861 1155..1173
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1248
spn-ENP_476741.1 HrpA 114..>697 CDD:441249 211/622 (34%)
DEXHc_TDRD9 115..295 CDD:350746 85/195 (44%)
TUDOR 892..1016 CDD:425754
Blue background indicates that the domain is not in the aligned region.

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