DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kl and CG9701

DIOPT Version :9

Sequence 1:	NP_038851.2	Gene:	Kl / 16591	MGIID:	1101771	Length:	1014	Species:	Mus musculus
Sequence 2:	NP_648918.1	Gene:	CG9701 / 39872	FlyBaseID:	FBgn0036659	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	194/547 - (35%)
Similarity:	266/547 - (48%)	Gaps:	86/547 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 LLLLHLLLLALRARCLSAEPGQGAQTWARFARAPAPEAAGLLHDTFPDGFLWAVGSAAYQTEGGW 82
            ::.:.|.|..|.|.||.:...|..:                    ||:.|||.|||::||.||||
  Fly     1 MMQIILPLFVLTASCLGSPVSQTRR--------------------FPNDFLWGVGSSSYQIEGGW 45

Mouse    83 RQHGKGASIWDTFTHHSGAAPSDSPIVVAPSGAPSPPLSSTGDVASDSYNNVYRDTEGLRELGVT 147
            ....||.||||..||.......|               .|.|||::|||:...||.:.::||.|.
  Fly    46 NADDKGESIWDFLTHTHPEKIVD---------------RSNGDVSADSYHQWKRDVQMVKELHVG 95

Mouse   148 HYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANR 212
            .||||:||.|::|.|.....:..|::||..|::.|....:.|:||:|||:|||:||: .|||.|.
  Fly    96 TYRFSLSWPRIMPGGYMNHVSTAGIKYYSNLIDELLRYNITPMVTIYHWELPQKLQE-LGGWTNP 159

Mouse   213 ALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAH 277
            .:...|:|||.|....:|.:||.|.|::.|:.|..|||....:||.........||..||||.||
  Fly   160 EIIPLFKDYARLVLEMYGDRVKIWTTVNEPWHVCEHGYGVDYMAPSYNYPGIPAYLCGHNLLKAH 224

Mouse   278 AKVWHLYNTSFRPTQGGRVSIALSSHWINPRRMTDYNIREC-QKSLDFVLGWFAKPIFI-DGDYP 340
            |:|.|:|...|:|.||||:.|.|.:.|..||.......||. ::::.|.:|||..|||. .|:||
  Fly   225 AEVVHMYRELFQPRQGGRMGITLDTSWPEPRDPNSAEDREASERAMQFYVGWFGHPIFSKHGNYP 289

Mouse   341 ESM---KNNLS--------SLLPDFTESEKRLIRGTADFFALS-----------FGPTLSFQLLD 383
            :.|   ..|||        |.||:||..|...||||:|||.::           ...|..|.:..
  Fly   290 KVMIERIRNLSKEQGFGARSRLPEFTTEEIHRIRGTSDFFGINSYTSNLVTSNGHNNTGKFPVPS 354

Mouse   384 PNMKFRQLES------------------PNLRQLLSWIDLEYNHPPIFIVENGWFVSGTTKRDDA 430
            .|.....:||                  ..:..||.||..|||.|.|.:.|||  ||.....:|.
  Fly   355 FNHDMGVVESQEGVDWPGSGSVWLKVYPKGMYNLLMWIHREYNAPEIIVTENG--VSDRGGLEDY 417

Mouse   431 KYMYYLKKFIMETLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSS 495
            ..:.|...::...|.|:. ||.::.||.||||||.:||..|:|.:.||::|||.|..:...||.|
  Fly   418 ARVDYYNLYLSAVLDAME-DGANISGYIAWSLMDSYEWKAGFSEKFGLYHVDFNSPQRTRTPKIS 481

Mouse   496 ALFYQKLIEDNGF-----PPLPENQPL 517
            |..:.:|.:.|..     |.|.|.|.|
  Fly   482 ARVFAQLCKTNTIDWSYRPKLDEEQQL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kl	NP_038851.2	Glyco_hydro_1	59..508	CDD:304882	182/490 (37%)
		Glycosyl hydrolase-1 1	59..508		182/490 (37%)
		Glycosyl hydrolase-1 2	517..955		1/1 (100%)
		Glyco_hydro_1	519..955	CDD:304882
CG9701	NP_648918.1	Glyco_hydro_1	22..492	CDD:304882	182/508 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257823at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100193
Panther	1	1.100	-	-	O	PTHR10353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3725
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.780