DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kit and htl

DIOPT Version :9

Sequence 1:	NP_001116205.1	Gene:	Kit / 16590	MGIID:	96677	Length:	979	Species:	Mus musculus
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	199/727 - (27%)
Similarity:	315/727 - (43%)	Gaps:	175/727 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse   251 NPQPQHIAQVKHNS--WHRGDFNYERQE-TLTISSARVDDSGVFMCYANNTFGSANVTTTLKVVE 312
            ||:| :|...::.:  |.||..:.:|.. |||:......|.|.:.|...|:.|.....|.:.|.:
  Fly   130 NPEP-NITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSD 193

Mouse   313 KGFINISPVKNTTVFVTDGENVDLVVEYEAYPKPEH-------QQWIY-----MNRTSANKGKDY 365
            :  :|..|     :.:|...|:.|||........::       :.||:     |...|.|:.
  Fly   194 R--VNHKP-----ILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRS--- 248

Mouse   366 VKSDNKSNIRYVNQLRLTRLKGTEGGTYTFLVSNSDASASVTFNVYVNTKPEILTYDRLINGM-- 428
            :.:::|..:.:||      ::..:.|.||.:.|||...::.|            .|.|::..:
  Fly   249 IIAEDKDQLDFVN------VRMEQEGWYTCVESNSLGQSNST------------AYLRVVRSLHV 295

Mouse   429 LQC-VAEGFPEPTIDWYFCTGAEQRCTTPVSPVDVQVQNVSVSPFGKLVVQSSIDSSVFRHNGTV 492
            |:. ||.|....|                        ..|.:..||.|:.
  Fly   296 LEAGVASGSLHST------------------------SFVYIFVFGGLIF--------------- 321

Mouse   493 ECKASNDVGKSSAFFNFAFKGNN-----KEQIQAHTLFTPLLIGFVV-----AAGAMGIIVMVLT 547
                   :..::.|..:|.:...     |::|:....:|..:|.|..     ::|:|..::|
  Fly   322 -------IFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIM--- 376

Mouse   548 YKYLQKPMYEVQWKVVEEI-NGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATA 611
                  |:..:|.:....: |||.....:..:.|.|..||.||:.|..|.|||.||||:||.|..
  Fly   377 ------PVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV 435

Mouse   612 YGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYC 676
            ...|       |||||:|......:..:|:.|::|:..:|.|:||:||||.|:..||..||.||.
  Fly   436 NNAI-------VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYA 493

Mouse   677 CYGDLLNFLRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKR 741
            .:|:|.:|                    ||||.....:...|||      :|..|......|:|
  Fly   494 PHGNLKDF--------------------LYKNRPFGRDQDRDSS------QPPPSPPAHVITEK- 531

Mouse   742 RSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGR 806
                                        ||:.|::|:|:||.:|||:.||||||||||:|::...
  Fly   532 ----------------------------DLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDY 568

Mouse   807 ITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSP 871
            :.||.||||||||::...|....|.|||:|||||||:....|..:||||||||.|||:.:.|..|
  Fly   569 VLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQP 633

Mouse   872 YPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKH 936
            ||.:....:.|..:..|.||..|......:|.:|:.||..:...||.|.::|:.::|.:.....:
  Fly   634 YPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDY 698

Mouse   937 IYSNLANCNPNP 948
            :..::||.:..|
  Fly   699 LDVDIANLDTPP 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kit	NP_001116205.1	ig	217..308	CDD:278476	17/59 (29%)
		IG_like	221..310	CDD:214653	17/61 (28%)
		Ig4_SCFR	314..414	CDD:143268	22/111 (20%)
		IG_like	325..412	CDD:214653	20/98 (20%)
		Ig	427..501	CDD:299845	9/76 (12%)
		PTKc_Kit	556..930	CDD:270682	134/374 (36%)
		Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250	571..573		0/1 (0%)
		Pkinase_Tyr	592..926	CDD:285015	123/333 (37%)
htl	NP_524394.2	Ig	112..191	CDD:299845	17/61 (28%)
		IG_like	113..191	CDD:214653	17/61 (28%)
		IG_like	205..289	CDD:214653	20/104 (19%)
		PKc_like	404..692	CDD:304357	130/349 (37%)
		STYKc	416..688	CDD:214568	123/333 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810