DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DHX8 and Dhx15

DIOPT Version :9

Sequence 1:	NP_004932.1	Gene:	DHX8 / 1659	HGNCID:	2749	Length:	1220	Species:	Homo sapiens
Sequence 2:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	350/708 - (49%)
Similarity:	485/708 - (68%)	Gaps:	28/708 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   514 PDAEGRQIAANMRGI-----GMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQ 573
            |:|.....||....:     |.:||..|......   ....|.::.| ::.::|.:||:::.:..
  Fly    20 PEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPL---TNTPYSQRYQ-NLYKKRIALPVFEYQAD 80

Human   574 LVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGK--IGCTQPRRVAAMSVAKRVSEEFGC 636
            .::.:..:|.::::|||||||||||.|:..:.. .|:|:  :.|||||||||||||:|||||...
  Fly    81 FMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFA-VSKGRKGVSCTQPRRVAAMSVAQRVSEEMDV 144

Human   637 CLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLL 701
            .||:||||:||||||::.:|::|||||||||||.:.||.|.||.:|:||||||||:.||:|.|:|
  Fly   145 KLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVL 209

Human   702 KKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQ 766
            |:.:::|.|:||:|.||||||.||.|||..||:..:||||:||||.||.|||.|||:|::.||:|
  Fly   210 KEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQ 274

Human   767 IHLTEP-PGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPP 830
            ||:.|. .||||:||||||||:.||:.:...:.:||.::.||..:|:||.||..:|.|||:||||
  Fly   275 IHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPP 339

Human   831 GS------RKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAG 889
            .:      ||||::||||||||||||:.:|:||||.||||||.:..::.|:|:|||:|.|:||:|
  Fly   340 PNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSG 404

Human   890 RAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETL 954
            |||||.||||:|||||:|:::||.....|||.|:||.:.||.||.:||:||:.|||||.|..|||
  Fly   405 RAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETL 469

Human   955 ITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFY 1019
            :.|:|.|..|.||||:|.||.||..|:||||:|.|.||||.|....||.|:|:|.:||||...|.
  Fly   470 MRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFV 534

Human  1020 RPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLG 1084
            ||.:.:..||:.|.:|...:|||||||.||:::|.:.....|||||||..|||:.|.::|:|:..
  Fly   535 RPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLAR 599

Human  1085 IMDRHKLDVVSCGKST----VRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQ 1145
            ||||..|...|...::    |.::||:..|||...|..:....|.|:.|.|.|.:|||:.| :.:
  Fly   600 IMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCL-DHK 663

Human  1146 PEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSD----PTKLSKQKKQQRLE 1199
            |:||:|:|.|||||.|:|.||.:.|.||...||.::.:::    ..|...:..|||||
  Fly   664 PDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDLNNFPQCEAKRQLELLQQRLE 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..266
		RpsA	<263..422	CDD:223613
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..372
		HrpA	557..1219	CDD:224557	340/660 (52%)
		DEAH box	685..688		2/2 (100%)
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	12/55 (22%)
		DEXDc	67..255	CDD:214692	105/188 (56%)
		DEXDc	91..228	CDD:238005	83/137 (61%)
		HELICc	315..408	CDD:197757	54/92 (59%)
		HA2	478..561	CDD:214852	43/82 (52%)
		OB_NTP_bind	595..698	CDD:285018	42/103 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730