Protein Alignment DHX8 and Dhx15

DIOPT Version :10

• Sequence 1: NP_004932.1
• Gene: DHX8 / 1659
• HGNCID: 2749
• Length: 1220
• Species: Homo sapiens
• Sequence 2: NP_610269.1
• Gene: Dhx15 / 35654
• FlyBaseID: FBgn0033160
• Length: 729
• Species: Drosophila melanogaster
• Alignment Length: 708
• Identity: 350/708 - (49%)
• Similarity: 485/708 - (68%)
• Gaps: 28/708 - (3%)

Human   514 PDAEGRQIAANMRGI-----GMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQ 573
            |:|.....||....:     |.:||..|......   ....|.::.| ::.::|.:||:::.:..
  Fly    20 PEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPL---TNTPYSQRYQ-NLYKKRIALPVFEYQAD 80

Human   574 LVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGK--IGCTQPRRVAAMSVAKRVSEEFGC 636
            .::.:..:|.::::|||||||||||.|:..:.. .|:|:  :.|||||||||||||:|||||...
  Fly    81 FMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFA-VSKGRKGVSCTQPRRVAAMSVAQRVSEEMDV 144

Human   637 CLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLL 701
            .||:||||:||||||::.:|::|||||||||||.:.||.|.||.:|:||||||||:.||:|.|:|
  Fly   145 KLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVL 209

Human   702 KKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQ 766
            |:.:::|.|:||:|.||||||.||.|||..||:..:||||:||||.||.|||.|||:|::.||:|
  Fly   210 KEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQ 274

Human   767 IHLTEP-PGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPP 830
            ||:.|. .||||:||||||||:.||:.:...:.:||.::.||..:|:||.||..:|.|||:||||
  Fly   275 IHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPP 339

Human   831 GS------RKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAG 889
            .:      ||||::||||||||||||:.:|:||||.||||||.:..::.|:|:|||:|.|:||:|
  Fly   340 PNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSG 404

Human   890 RAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETL 954
            |||||.||||:|||||:|:::||.....|||.|:||.:.||.||.:||:||:.|||||.|..|||
  Fly   405 RAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETL 469

Human   955 ITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFY 1019
            :.|:|.|..|.||||:|.||.||..|:||||:|.|.||||.|....||.|:|:|.:||||...|.
  Fly   470 MRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFV 534

Human  1020 RPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLG 1084
            ||.:.:..||:.|.:|...:|||||||.||:::|.:.....|||||||..|||:.|.::|:|:..
  Fly   535 RPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLAR 599

Human  1085 IMDRHKLDVVSCGKST----VRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQ 1145
            ||||..|...|...::    |.::||:..|||...|..:....|.|:.|.|.|.:|||:.| :.:
  Fly   600 IMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCL-DHK 663

Human  1146 PEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSD----PTKLSKQKKQQRLE 1199
            |:||:|:|.|||||.|:|.||.:.|.||...||.::.:::    ..|...:..|||||
  Fly   664 PDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDLNNFPQCEAKRQLELLQQRLE 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..266
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..372
		HrpA	556..>1187	CDD:441249	334/647 (52%)
		DEAH box	685..688		2/2 (100%)
Dhx15	NP_610269.1	HrpA	71..>691	CDD:441249	329/621 (53%)