Protein Alignment DHX8 and l(2)37Cb

DIOPT Version :10

• Sequence 1: NP_004932.1
• Gene: DHX8 / 1659
• HGNCID: 2749
• Length: 1220
• Species: Homo sapiens
• Sequence 2: NP_609946.1
• Gene: l(2)37Cb / 35192
• FlyBaseID: FBgn0086444
• Length: 894
• Species: Drosophila melanogaster
• Alignment Length: 1059
• Identity: 450/1059 - (42%)
• Similarity: 616/1059 - (58%)
• Gaps: 194/1059 - (18%)

Human   155 SAAGQEKQRDAEHRDRTKK-KKRSRSRDRNRDRDRDRERN-RDRDHKRR--HRSRSRSRSRTRER 215
            |::|:|.  |:|...|.|. ::|.....|.:.||.||.|| .|....||  ..:..|.:....:|
  Fly    13 SSSGEEP--DSEEESRLKDLQERDEFASRLKKRDDDRTRNVVDSTGGRRAIEEATKRLKLEHEDR 75

Human   216 NKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGC 280
            :|:....|.:||.|...| ||| ||..|...|...|::             :::..|
  Fly    76 DKIVPHLRLQSRRQYLEK-RKD-DKVAELEADILDDEY-------------LFDESV-------- 117

Human   281 FVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED 345
                  |.||.:     .|...:.::.|:|.                           :.|...:
  Fly   118 ------LTKREK-----EEREYKKQLLNIAK---------------------------EHEKARE 144

Human   346 LNPNRRRNL-----VGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQM 405
            |...:|.|:     .||.:|                   .||.|..|::   ..|:.:|||.:|:
  Fly   145 LERIQRYNMPQDLKKGERSE-------------------YVEVDEFEKQ---PNSEQKKWEAEQL 187

Human   406 IAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDG 470
            .:|..       .|..:       |.:.:|:.|: |::::..|::..|.              ||
  Fly   188 ASARF-------HFGAK-------DAKAEEEYEL-LLDDQIDFIQALTL--------------DG 223

Human   471 SLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDI 535
            |..:::..|..|.::.|:
  Fly   224 SREKSSSRQPELTEKERK----------------------------------------------- 241

Human   536 PEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ 600
                               ::::.|.|.|||:|..||.|:.||.::|:||:.||||||||||:.|
  Fly   242 -------------------RLTLDETRRSLPVYPFKEDLIAAVKEHQVLIIEGETGSGKTTQVPQ 287

Human   601 YLAEAGYTSRGK-IGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDG 664
            ||.|||:|...| |||||||||||||||.||:||.|..||.||||:||||||||..|::||||||
  Fly   288 YLVEAGFTKDKKMIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSDRTILKYMTDG 352

Human   665 MLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYF 729
            .|.||.|.:|||..|:::::|||||||:|||:||||:|...:.|.::||:::||||||.|||.:|
  Fly   353 TLHREFLSEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPELKLLISSATLDAEKFSAFF 417

Human   730 YEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILY 794
            .:||||.||||.|||:|.|||.||.||:||..::|:|||.|:|.||||||||||:||:|..|:|:
  Fly   418 DDAPIFRIPGRRYPVDIFYTKAPEADYIDACCVSVLQIHATQPLGDILVFLTGQDEIETCQEVLH 482

Human   795 ERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGF 859
            :|:|.||..:.|||::|||:.|||:||.:||:|.||.:|||::||||||||||||.|.||:||||
  Fly   483 DRVKRLGSKIRELIVIPVYANLPSDMQAKIFEPTPPNARKVILATNIAETSLTIDNIIYVIDPGF 547

Human   860 VKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTN 924
            .||..:||:||::.|:|.|||:|.|.|||||||||.||||:||||..||:.|:....||||||.|
  Fly   548 AKQNNFNSRTGMESLMVVPISKASANQRAGRAGRTAPGKCFRLYTAWAYKHELEDNTVPEIQRIN 612

Human   925 LASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPML 989
            |.:.||.|||:|||||:.|||:|.||.|||:.|:||||.||||:..|.||:|||||||||::||:
  Fly   613 LGNAVLMLKALGINDLIHFDFLDPPPHETLVLALEQLYALGALNHHGELTKLGRRMAEFPVDPMM 677

Human   990 CKMLIMSVHLGCSEEMLTIVSMLSVQN-VFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWK 1053
            .|||:.|....|||||:||.:||||.: :|||||||...||..:..|:...||||:||.|||.|.
  Fly   678 GKMLLASEKYKCSEEMVTIAAMLSVNSAIFYRPKDKIIHADTARKNFNHMHGDHLSLLQVYNQWA 742

Human  1054 NNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKK 1118
            ...:|..||||||||.||::||:|:|:|::|:|.|.::|:|||...||.|:||..:|:|.:.|:.
  Fly   743 ETDYSTQWCYENFIQYRSMKRARDVREQLVGLMQRVEIDMVSCLPETVNVRKAATAGYFYHVARL 807

Human  1119 DPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFK- 1182
            .....|:|:...|.|.|||:|:||...|.||:|||||.|:|||||:|..|:.:||:|.||.::|
  Fly   808 SKGGHYKTIKHNQTVMIHPNSSLFEELPRWVLYHELVFTSKEYMRQVIEIESKWLLEVAPHYYKA 872

Human  1183 --VSDPTKLSKQKKQQRLE 1199
              :.|.|.....|...|.|
  Fly   873 KELEDSTNKKMPKVAGRAE 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..266		34/114 (30%)
		S1_DHX8_helicase	265..343	CDD:240189	8/77 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..372		7/39 (18%)
		HrpA	556..>1187	CDD:441249	375/635 (59%)
		DEAH box	685..688		2/2 (100%)
l(2)37Cb	NP_609946.1	PTZ00121	<6..267	CDD:173412	82/433 (19%)
		HrpA	251..>868	CDD:441249	370/616 (60%)