DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif9 and Kif3C

DIOPT Version :9

Sequence 1:	XP_006512005.1	Gene:	Kif9 / 16578	MGIID:	1098237	Length:	839	Species:	Mus musculus
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	737	Identity:	195/737 - (26%)
Similarity:	294/737 - (39%)	Gaps:	231/737 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    54 KKVQAFVRVRPTDDFAHE-----MIKYGE-----DNKSIDIHLKKDTRRGVVNNQQTDWSFKLDG 108
            :.::..||.||.:....|     :::..|     .|.|..|..:|......|.|.:||
  Fly     3 ENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTD------- 60

Mouse   109 VLHNASQDLVYETVAKDAVSQALDGYNGTIMCYGQTGAGKTYTMTGATENYKH-RGILPRALQQV 172
                  .:::|:.:....|...::||||||..|||||.|||:||.| .||:.: .||:|:....:
  Fly    61 ------TEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQG-DENFSNSTGIIPKCFDHI 118

Mouse   173 FRMIEERPTHAITVRVSYLEIYNENLFDLLS-------------TLPYVG---PSVTPMTIVENP 221
            |..|...........|:|||||||.:.|||:             .||.:|   |::|...:|...
  Fly   119 FERISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNAN 183

Mouse   222 QGIFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYMEAHSRTLSDEKYI 286
            |                 .:..|..|..||:.|:..|||||||||.||||       ||....::
  Fly   184 Q-----------------CYDWLHFGNKNRVTAATLMNKNSSRSHTIFTI-------TLEQSPFL 224

Mouse   287 TS------------KINLVDLAGSERLSKTGSEGRVLKEATYINKSLSFLEQAIIALGDQNRDHV 339
            .|            |::|||||||||..|||::|..||||:.||.|||.|...|.:|.|....||
  Fly   225 NSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHV 289

Mouse   340 PFRQSKLTHALKDSLGGNCNMVLVTNIYGEAAQLDETLSSLRFASRMKLVTTEPAINEKYDAERM 404
            |||.||||..|:||||||...::::.|.......|||:|:||:|||.|.::.:|.|||.....|:
  Fly   290 PFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARL 354

Mouse   405 VKNLEKELALLKQELAIHDSLSNRTLVNYD-------PMDEIQIAEINSQVRRYLEGTLDEIDII 462
             :..:.|:..||:.|.....:.|:   |.|       |:..||...:||         ...:.||
  Fly   355 -RQYQNEILYLKRMLQESQQIINK---NNDPNKIIKSPLKIIQHTNMNS---------TKNVQII 406

Mouse   463 NL-RQIQEVFNQFRVVLSQQEQEVESALRRKYTLIDKNDFAAISAVQKVGLMDIEGNLVGEPDGQ 526
            :| |..:..|.....:|:          :..:.||...:...:.|..::.|  |:.:|:|
  Fly   407 DLGRNCKASFKTNNSILT----------KPNFPLIQSKEEVQLQARSRIDL--IKRSLIG----- 454

Mouse   527 SFGLGVAPFSVKPGKKPKTKKTPKDQFSSSARKEGASSPVSGKDFDVASISKTQLIPSSKDGDLK 591
              |..:..|.:|.              ...|||
  Fly   455 --GERIHDFELKE--------------KHMARK-------------------------------- 471

Mouse   592 DMLARERETSSIEPLISDSPKEELRAPRPSTPPSRTVAFEEFKNERGSEINRIFKENKSILNERK 656
              .|.:|..|:|...:|                                  |:..|::.:|.
  Fly   472 --YAAQRHLSAIAIALS----------------------------------RVKCEDRDLLQ--- 497

Mouse   657 KRASETTQRINAIKQEIDETKDALNFQKSLREKQGEYENKGLMIIDEEEFLLILKLKDLKKQY-- 719
                   .....|.||||...|.:...|                  |:..:|.:::.||..::
  Fly   498 -------GHYATITQEIDIKNDYIRKCK------------------EKIKMLEMEVSDLNSEFQL 537

Mouse   720 -RNEY-QELRDLRAEIQYCQRL 739
             |.:| .|:|:|..::::.|:|
  Fly   538 DREDYLDEIRNLGRQVKFHQQL 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif9	XP_006512005.1	KISc_KIF9_like	55..387	CDD:276826	132/370 (36%)
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	133/373 (36%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	132/366 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810