DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif7 and Kif3C

DIOPT Version :9

Sequence 1:	NP_001278151.1	Gene:	Kif7 / 16576	MGIID:	1098239	Length:	1348	Species:	Mus musculus
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	197/696 - (28%)
Similarity:	301/696 - (43%)	Gaps:	161/696 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 VRVALRVRPLLPKELLHGHQSCLRVEPERGRIT-----LGRDRHFGFHVVLGEDTGQEAVYQACV 75
            ::|.:|.||:...|.....|:.:.:......:|     :.:.:.|.|..|....|..|.:|....
  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDEMC 69

Mouse    76 QPLLEAFFEGFNATVFAYGQTGSGKTYTM-GEASVASLHEDEQGIIPRAMAEAFKLIDENDLLDC 139
            ..|:|:..||:|.|:|||||||.|||:|| |:.:.:    :..||||:.....|:.|.....:..
  Fly    70 YSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFS----NSTGIIPKCFDHIFERISMTTNVRY 130

Mouse   140 LVHVSYLELYKEEFRDLLEVGTASRDIQLREDDRGNVVLCGVKEV-------------DVEGLDE 191
            |..|:|||:|.|..|||           |.:::..||:...:||:             .|...::
  Fly   131 LALVTYLEIYNERIRDL-----------LNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQ 184

Mouse   192 VLSLLEMGNAARHTGATHFNRLSSRSHTVFTVTLEQRGRTP--SRLPRPAAGHLLVSKFHFVDLA 254
            ....|..||..|.|.||..|:.||||||:||:||||   :|  :.:...|.|.:...|...||||
  Fly   185 CYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQ---SPFLNSIGSDAFGGICRGKLSLVDLA 246

Mouse   255 GSERVLKTGSTGERLKESIQINSTLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAK 319
            ||||..|||:.|:||||:.|||.:|.|||||||:|.|  .:..|:|:||||:||:|:||||||.|
  Fly   247 GSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD--GKAKHVPFRDSKLTRLLQDSLGGNTK 309

Mouse   320 TVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVNWRPEAERVPE---------------EQA 369
            |:||:|:||:...:|||::||.|||||:||.|:..:|..|:..|:.:               :|.
  Fly   310 TLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQI 374

Mouse   370 AGARGPPRH--RSETRIIHRGRRVPCPAVGSAAVAAGLGAECARCRARTSAAYSLLRELQAEPGL 432
            ......|..  :|..:||..........|    ....||..|       .|::.....:..:|..
  Fly   375 INKNNDPNKIIKSPLKIIQHTNMNSTKNV----QIIDLGRNC-------KASFKTNNSILTKPNF 428

Mouse   433 P--------GAAARKVRDWLCAVEGERSTLSSASGPDSGI-ESAPAEDQAAQGTSGRKGDEGTQQ 488
            |        ...||...|.:     :||.:......|..: |...|...|||           :.
  Fly   429 PLIQSKEEVQLQARSRIDLI-----KRSLIGGERIHDFELKEKHMARKYAAQ-----------RH 477

Mouse   489 LLTLQSQVARLEEENRDFLAA-LEDAMEQYKLQSDRLREQQE-------EMVELRLRLEL----- 540
            |..:...::|::.|:||.|.. .....::..:::|.:|:.:|       |:.:|....:|
  Fly   478 LSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDY 542

Mouse   541 ----------------------AQPG-----WGAPGLLQG-----------LPPGSFVPRPHTAP 567
                                  :.||     |....:||.           :|....:..|....
  Fly   543 LDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPESDLIKLPPATQ 607

Mouse   568 LGGAHTHMLGMMPSTCLPGEEVSSEQQ------VVSGKEVKAEVLA 607
            ..|.|          |:....:.||.|      :|.|::|....:|
  Fly   608 KSGLH----------CIHPLVIHSENQHNNQNEIVVGEKVSISNIA 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif7	NP_001278151.1	KISc_KIF4	15..350	CDD:276823	140/354 (40%)
		Interaction with SMO. /evidence=ECO:0000269\|PubMed:25644602	358..1211		54/333 (16%)
		Interaction with DLG5. /evidence=ECO:0000269\|PubMed:25644602	358..479		25/146 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..486		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..674		1/1 (100%)
		Smc	<734..1063	CDD:224117
		PRK11281	949..>1202	CDD:236892
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1314
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1328..1348
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	139/353 (39%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	138/348 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910