DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif5b and cmet

DIOPT Version :9

Sequence 1:	NP_032474.2	Gene:	Kif5b / 16573	MGIID:	1098268	Length:	963	Species:	Mus musculus
Sequence 2:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster

Alignment Length:	1028	Identity:	270/1028 - (26%)
Similarity:	449/1028 - (43%)	Gaps:	217/1028 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse    43 SKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGI 107
            ::||.||.||....|.::|::..||.||...::|:|||||||||||||||:||.|   |.:..|:
  Fly    41 AEPYVFDYVFDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGV 102

Mouse   108 IPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERF 172
            :....::||..|.|..|. :|.::|.|.|||.:||.|||:....:|.:||..|.:..| .|.|..
  Fly   103 MVLAAKEIFQQISSETER-DFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECI 165

Mouse   173 VCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINV---KQENTQTEQKLSGKLYLVDLAG 234
            :.|..:::..:..|...|.|..|||||.|||||:||.|.:   |.:::..:..:...|.||||||
  Fly   166 ITSEVDLLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAG 230

Mouse   235 SEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEG--STYVPYRDSKMTRILQDSLGGNCRTT 297
            ||:..:|||.||.|.|..:|||||..|.|||.:|:|.  :.:..|||||:|||||.|||||..|:
  Fly   231 SERADQTGARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTS 295

Mouse   298 IVICCSPSSYNESETKSTLLFGQRAKTIK-----------NTVCVNVELTAEQWKKKYEKEKEKN 351
            |:....||...||:  |||.|..|||.|:           .|:...:|...:..|.|..:|:.||
  Fly   296 IICTIKPSIMEESQ--STLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKN 358

Mouse   352 KTLRNTIQWLENELNR----------------------W------------RNGETVPIDEQFDK 382
            :. :..::.||.::..                      |            ..|.|....:||.|
  Fly   359 EN-QQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPK 422

Mouse   383 EK---------------------------ANLEAFTADKDIA----------------------- 397
            ..                           .:|:..|....|:
  Fly   423 VSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPML 487

Mouse   398 ---------------ITSDKPAAAVGMAGSFTDAERR---KCE------EELAKLYKQLDDKDEE 438
                           :|:||....:.....||..|:.   :||      |:||::..|.|:.::|
  Fly   488 TIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQE 552

Mouse   439 INQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAV--N 501
                 .|.||.:...|::|  :.|.|.|.:...::::.|:.:....|:.:: :::...::||  .
  Fly   553 -----SLAEKERYDALEKE--VTSLRADNEAANSKISELEEKLSTLKQTMR-IMEVENQVAVGLE 609

Mouse   502 YDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL-KEMTNHQKKRAAEMMASLLKDLAEI 565
            ::.::.:...|.:..:||| .|.:|.:|:.|:...|..| :::..:.|:.....:|...:|:|
  Fly   610 FEFEAHKKSSKLRVDDLLS-ALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIA-- 671

Mouse   566 GIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA 630
                |::...:.|     :.|..:|.|...|...|       |.||.........|:|..|....
  Fly   672 ----GDSICNKCE-----ELEKLIADLESKKNSCE-------CDQLRLEIVSVRDKLESVESAFN 720

Mouse   631 ACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLGEELVQLRA------------QEKVHEM 683
            .....|.|.....:.|::.|...:....||:|..|:|.::....:|            |||..::
  Fly   721 LASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQKL 785

Mouse   684 EKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKEKLITDLQDQNQKMVLEQERLR 748
            ::|:......|.....|..|::|:.....|..|:||.:.:|..:.::|::|:....:    |:||
  Fly   786 QEEYEQLESRARSASSAEFQRLQNDNTKFQADIASLNERLEEAQNMLTEVQNSESTV----EKLR 846

Mouse   749 VEHERLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVK- 812
            :::..|.|       |:.||   :...|:.:::...|...:.:.:|....||:...|...:.|:
  Fly   847 IQNHELTA-------KIKEL---ETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSHVEE 901

Mouse   813 --KSAEVDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPK---LEKRLRATAE 872
              :|:.:.||    ...|||.|:.| :...||::..:|:         ||..   :.:..||...
  Fly   902 SMRSSGISSD----FDEQKQDINLL-HQFVQLSESVQQI---------ELQHHSGISRLFRANQM 952

Mouse   873 RVKALESALKEAKENASRDRKRYQQEVDRIKEAVRS---KNMARRGHSAQIAK 922
            ::...|..||...|:|     .|.:|.:|..:|...   |...:| |..||.:
  Fly   953 KLDQSEPGLKLCLESA-----EYIEEDNRQSDATEPICLKGFLKR-HRFQIKR 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif5b	NP_032474.2	KISc_KHC_KIF5	6..325	CDD:276820	129/286 (45%)
		KISc	8..332	CDD:214526	131/304 (43%)
		DUF4337	<462..>538	CDD:290935	15/77 (19%)
		TACC	467..662	CDD:282818	37/197 (19%)
		TMPIT	598..>686	CDD:285135	20/99 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..963		5/18 (28%)
		Globular	915..963		3/8 (38%)
cmet	NP_524993.3	KISc	8..328	CDD:214526	130/293 (44%)
		Motor_domain	8..321	CDD:277568	129/286 (45%)
		Smc	<680..1449	CDD:224117	81/366 (22%)
		TMPIT	779..>867	CDD:285135	24/101 (24%)
		Smc	1042..1910	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910