Protein Alignment Kif5a and cmet

DIOPT Version :10

• Sequence 1: NP_032473.2
• Gene: Kif5a / 16572
• MGIID: 109564
• Length: 1027
• Species: Mus musculus
• Sequence 2: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Alignment Length: 1095
• Identity: 290/1095 - (26%)
• Similarity: 476/1095 - (43%)
• Gaps: 287/1095 - (26%)

Mouse     6 NECSIKVLCRFRP-------LNQAEILRGDKFIPIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVY 63
            |..||:|..:.||       |.|.:..|.     |...|..    .:|||||.||....:.::|:
  Fly     5 NASSIQVCIKVRPCEPGLTSLWQVKERRS-----IHLADSH----AEPYVFDYVFDEGASNQEVF 60

Mouse    64 HACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLE 128
            ...|..||...:.|:|||||||||||||||:||.|   |.|..|::...|::||..|.|..|. :
  Fly    61 DRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG---DEQNPGVMVLAAKEIFQQISSETER-D 121

Mouse   129 FHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHV 193
            |.::|.|.|||.:||.|||:....:|.:||..|.:..| .|.|..::|..::|.::..|...|.|
  Fly   122 FLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCLGNKERTV 185

Mouse   194 AVTNMNEHSSRSHSIFLINI---KQENVETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNI 255
            ..|||||.|||||:||.|.|   |.::.:.:..:...|.||||||||:..:|||.||.|.|..:|
  Fly   186 GETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGARLKEGGHI 250

Mouse   256 NKSLSALGNVISALAEGTKS-YVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLM 319
            ||||..|.|||.:|:|...: :..|||||:|||||.|||||..|::.....||...  |::|||.
  Fly   251 NKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKPSIME--ESQSTLS 313

Mouse   320 FGQRAKTIKNTASVNLELTAEQWKKKYEK----------EKEKTKAQKETIAKLEAEL------- 367
            |..|||.|:....||..::.....|:.|:          |:|:....::.:..||.::
  Fly   314 FATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLERQIKHDMHKI 378

Mouse   368 ------------------------------------------------------------SRWRN 372
                                                                        .||
  Fly   379 ICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRW-- 441

Mouse   373 GENVPETERLAG------EDSALGAELCEETPVNDNS--------SIVVRIAPE----------- 412
             :|:|:|..:.|      |.:::..|......::..|        .:.:|..|:
  Fly   442 -DNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTPKGPLTT 505

Mouse   413 ERQKYE------------------EEIRRLYKQLDD---KDDEINQQSQLIEKLKQQMLDQEELL 456
            ::.|.|                  ||::.|.::|.:   :.|.:.|:| |.||.:...|::|  :
  Fly   506 DKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQES-LAEKERYDALEKE--V 567

Mouse   457 VSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQ 521
            .|.|.|||....::|.|:.:....|..:: :::...::||..:   .|.|...:.::|.||:|
  Fly   568 TSLRADNEAANSKISELEEKLSTLKQTMR-IMEVENQVAVGLE---FEFEAHKKSSKLRVDDL-- 626

Mouse   522 KVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMRDLSEFSVIVGNGEIKLPVEISGAIEEEFTV 586
             ::.:|..||.::.||           :.|:.|.||:...|   ..|.:     :|.|.|:|...
  Fly   627 -LSALLEKESTIESLQ-----------KSLDNLTRDVLRNS---KEGHM-----LSIAPEQEDIA 671

Mouse   587 ARLYISKIKSEVKSVVKRCRQLENL---------QVECHR-KMEV-----------TGRELSSCQ 630
            .           .|:..:|.:||.|         ..||.: ::|:           :...|:|.:
  Fly   672 G-----------DSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESAFNLASSE 725

Mouse   631 LLISQHEAKIRSLTEYMQTVELKKRHLEESYDSLSDELARLQAH-ETVHEVALKDKEPDTQDA-E 693
            ::  |.......|::.:.|.:.....|:|.||:|..:....||. .|:||     |....|:. :
  Fly   726 II--QKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHE-----KHEHVQEKYQ 783

Mouse   694 EVKKALELQMENH-REAHHRQLARLRDEINEKQKTIDELKDLNQKLQ------LELEKLQADYER 751
            ::::..| |:|:. |.|...:..||:   |:..|...::..||::|:      .|::..::..|:
  Fly   784 KLQEEYE-QLESRARSASSAEFQRLQ---NDNTKFQADIASLNERLEEAQNMLTEVQNSESTVEK 844

Mouse   752 LKNEENEKSAKLQELTFLYERHEQ-----SKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKK 811
            |:.:.:|.:||::||...:|..::     |.|.::.::|..|        ||:...|..|:.|::
  Fly   845 LRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDA--------LREEIKQRPTSHVEE 901

Mouse   812 SAEMEPEDSGGIHS----QKQKISF------LENNLEQLTKVH----KQLVRDNADLRCELPKLE 862
            |..     |.||.|    |||.|:.      |..:::|:...|    .:|.|.|   :.:|.:.|
  Fly   902 SMR-----SSGISSDFDEQKQDINLLHQFVQLSESVQQIELQHHSGISRLFRAN---QMKLDQSE 958

Mouse   863 KRLRATAERVK---------------ALEGALKEAKEGAMKDKRRYQQEVDRIKE 902
            ..|:...|..:               .|:|.||..:   .:.||..|:.||..:|
  Fly   959 PGLKLCLESAEYIEEDNRQSDATEPICLKGFLKRHR---FQIKRLSQEHVDMGEE 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif5a	NP_032473.2	KISc_KHC_KIF5	7..327	CDD:276820	140/330 (42%)
		Microtubule-binding	174..315		66/144 (46%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000269|PubMed:21976701	271..361		34/100 (34%)
		Interaction with BICD2. /evidence=ECO:0000250|UniProtKB:Q12840	353..1027		142/727 (20%)
		PRK03918	<409..920	CDD:235175	130/590 (22%)
		Khc_CBD_cc	832..901	CDD:467880	19/93 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	906..937
		Globular	907..1027
cmet	NP_524993.3	Motor_domain	8..321	CDD:473979	140/328 (43%)
		SMC_prok_B	539..1431	CDD:274008	124/542 (23%)
		SMC_prok_B	1137..1926	CDD:274008
		YhaN	1717..2182	CDD:443752