DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif5a and Khc

DIOPT Version :9

Sequence 1:	NP_001034089.1	Gene:	Kif5a / 16572	MGIID:	109564	Length:	1027	Species:	Mus musculus
Sequence 2:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	946	Identity:	567/946 - (59%)
Similarity:	720/946 - (76%)	Gaps:	33/946 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 ECSIKVLCRFRPLNQAEILRGDKFIPIFQG---DDSVIIGGKPYVFDRVFPPNTTQEQVYHACAM 68
            |.||||:|||||||.:|...|.||:..|..   ::.:.|.||.|:||:||.||.:||:||:..|.
  Fly    10 EDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEAAK 74

Mouse    69 QIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKV 133
            .||.||||||||||||||||||||||||||.:.|....||||||..|||||||:|:.||||||||
  Fly    75 SIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHIKV 139

Mouse   134 SYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNM 198
            ||:|||:|||||||||:|.||||||||||||:|||.|||||||||::.:||:|||||||:|||||
  Fly   140 SYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTNM 204

Mouse   199 NEHSSRSHSIFLINIKQENVETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALG 263
            |||||||||:||||:||||:|.::||||||||||||||||||||||||.||||||||||||||||
  Fly   205 NEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALG 269

Mouse   264 NVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIK 328
            |||||||:|.|:::||||||:|||||:|||||.|||:.|||||:|:|::||||||.||:||||:|
  Fly   270 NVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVK 334

Mouse   329 NTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGED------- 386
            |...||.|||||:||::|||||||....|..:.|||.||:|||.||.|...|::..||
  Fly   335 NVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTP 399

Mouse   387 ---------SALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLI 442
                     :|..|.|..:.....|.|  ..:|..|:.:...|..|||:||||||:|||||||..
  Fly   400 NLEVEAAQTAAAEAALAAQRTALANMS--ASVAVNEQARLATECERLYQQLDDKDEEINQQSQYA 462

Mouse   443 EKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEE 507
            |:||:|:::||||:.:.|.:.|.:|.|::.:|.||::||:||||||||||||||||||||||::.
  Fly   463 EQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDN 527

Mouse   508 KSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMRDLSEFSVIVGNGEIKL 572
            |::....|.:||.||.:...:..:|||:|:::|.||:|||.|:|..|:|||.|....:..||..:
  Fly   528 KNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSI 592

Mouse   573 PVEIS-------GAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQ 630
            .:::|       ..:||:||:|||:|||:|:|.|::.:||..:|..|.:.::|:....::|...:
  Fly   593 DLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYR 657

Mouse   631 LLISQHEAKIRSLTEYMQTVELKKRHLEESYDSLSDELARLQAHETVHEVALKDKEPDTQDAEEV 695
            ||||||||:::||.|.|:..|.|||.|||..|||.:|.|:|:|.|.|..|..::|    |.|||:
  Fly   658 LLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEK----QRAEEL 718

Mouse   696 KKALELQMENHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYERLKNEENEKS 760
            :...:.||:..||||.||::.|||||..||..:||:||::|||.|..:::.||||:::.|:.|||
  Fly   719 RSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQEDAEKS 783

Mouse   761 AKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKS-AEMEPEDSGGIH 824
            ::||.:....||.||:::||||||:|||:|||||||||||||||:..|::|: ...|.|:.||..
  Fly   784 SELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSL 848

Mouse   825 SQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKD 889
            :||||||||||||:||||||||||||||||||||||||||||.|.|||||||.||||||||||:|
  Fly   849 AQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRD 913

Mouse   890 KRRYQQEVDRIKEAVRYKSSGKRGHSAQIAKPVRPG 925
            ::|||.||||||||||.|..|:||..||||||:|.|
  Fly   914 RKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSG 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif5a	NP_001034089.1	KISc_KHC_KIF5	7..327	CDD:276820	240/322 (75%)
		Microtubule-binding	174..315		113/140 (81%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000269\|PubMed:21976701	271..361		59/89 (66%)
		Interaction with BICD2. /evidence=ECO:0000250\|UniProtKB:Q12840	353..1027		308/597 (52%)
		Smc	<412..759	CDD:224117	164/353 (46%)
		DUF5401	<630..>902	CDD:375164	168/272 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..937		12/20 (60%)
		Globular	907..1027		12/19 (63%)
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	240/322 (75%)
		KISc	12..340	CDD:214526	242/327 (74%)
		Apolipoprotein	595..744	CDD:279749	65/152 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	643	1.000	Domainoid score	I164
eggNOG	1	0.900	-	-		E2759_KOG0240
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1143	1.000	Inparanoid score	I212
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		otm42515
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2595
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870