DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3c and Kif3C

DIOPT Version :9

Sequence 1:	NP_032471.2	Gene:	Kif3c / 16570	MGIID:	107979	Length:	796	Species:	Mus musculus
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	251/734 - (34%)
Similarity:	373/734 - (50%)	Gaps:	139/734 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 SEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQAD 72
            ||.:|||.||||:::.|:....:.|  :::....|::.||.|...: .|.|.||:||:..:....
  Fly     2 SENIKVVVRCRPMNQTEKERNCQNI--VEINEFAVSVTNPSARISQ-QKKFIFDSVYNMKTDTEV 63

Mouse    73 LYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQ 137
            :|||....|::|.::|:|||:|||||||.|||:||||........|:||..|:|||..||.:.|.
  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNV 128

Mouse   138 QYLVRASYLEIYQEEIRDLLSKEPGKRL---ELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGN 199
            :||...:|||||.|.|||||:|.....:   .|||.|..||.:..|::....|..:....::.||
  Fly   129 RYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGN 193

Mouse   200 QARAVGSTHMNEVSSRSHAIFVITVECS----ERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNA 260
            :.|...:|.||:.|||||.||.||:|.|    ..|||....|..|||:||||||||||.|.|
  Fly   194 KNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTG--- 255

Mouse   261 AGGPATQPTAGGGSGSGSASGSASSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLT 325
                                   :.|:|.||||:||||||||||||::|...::.|:|:||||||
  Fly   256 -----------------------AQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLT 297

Mouse   326 RLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIA 390
            ||||||||||.||:|::.:.|....|||::||||:|:|||||.|||::||||||..||::|.||.
  Fly   298 RLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEIL 362

Mouse   391 RLKAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYPEGSVIEAWVAEEEDDNNNNHHPPQPILEAAL 455
            .||..|::                                    .::..|.||  .|..|:::.|
  Fly   363 YLKRMLQE------------------------------------SQQIINKNN--DPNKIIKSPL 389

Mouse   456 E----KNMENYLQDQKERLEEE-KAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAK 515
            :    .||.:....|...|... ||:.:.:.|::::....|::.||::           :|.|..
  Fly   390 KIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEV-----------QLQARS 443

Mouse   516 YKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEML----LRDEETMELRGTY 576
            ...:..:.||||..|.|        .|||.:.:|.:...:|.:....:    ::.|:...|:|.|
  Fly   444 RIDLIKRSLIGGERIHD--------FELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHY 500

Mouse   577 SSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQD-LEEAQN--EQTR---ELKLKY-- 633
            :::.||:::|...::|...|::.::.|:.|.:.|:...|:| |:|.:|  .|.:   :|.||:
  Fly   501 ATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSS 565

Mouse   634 ---LIIENFIPPEEKNKIMNRLFLDCEEEQWR--------------------FQPLVPAGVNNSQ 675
               ....|:.|   ...:.|.|:.| :.:.||                    ..|||....|  |
  Fly   566 NPGKFDRNWTP---DTILQNSLWND-DLKMWRIPESDLIKLPPATQKSGLHCIHPLVIHSEN--Q 624

Mouse   676 MKKRPTSAVGYKRPISQYA 694
            ...:....||.|..||..|
  Fly   625 HNNQNEIVVGEKVSISNIA 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3c	NP_032471.2	KISc_KIF3	9..367	CDD:276822	163/364 (45%)
		Kinesin	16..367	CDD:278646	159/357 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..292		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422		0/24 (0%)
		GBP_C	<463..571	CDD:303769	22/112 (20%)
		coiled coil	540..551	CDD:293879	4/10 (40%)
		coiled coil	560..571	CDD:293879	1/14 (7%)
		Globular. /evidence=ECO:0000255	633..793		18/87 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..796
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	163/364 (45%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	159/357 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820