Protein Alignment Kif3a and Klp54D

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_001303355.1
• Gene: Klp54D / 47216
• FlyBaseID: FBgn0263076
• Length: 760
• Species: Drosophila melanogaster
• Alignment Length: 639
• Identity: 193/639 - (30%)
• Similarity: 305/639 - (47%)
• Gaps: 115/639 - (17%)

Mouse     4 NKSEKPESC----DNVKVVVRCRPLNEREKSMCYRQAVSVDE-----MRGTITVHKTDSSNEPPK 59
            :||...|.|    ||:.||||.||||::||...:...:....     :.|.....|...:.:..:
  Fly   152 SKSTGSEECSTPEDNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVR 216

Mouse    60 TFTFDTVFGPESKQLDVYNLTA-RPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGL---- 119
            .||::.||.|.:.|.|:.:.:. :.||:..:||::.|.|.|||||:|||.|:.|   .|.|
  Fly   217 VFTYNVVFEPGATQEDILDYSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTG---PPDLFVGK 278

Mouse   120 -------RGVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQR-LEVK-ERP 175
                   .|:|..||.::| .:.|...|..::::.|::|||||.|.|||.....:: |.|: .:.
  Fly   279 PNPKDPRHGLIFRSFLYLF-QLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKK 342

Mouse   176 DVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMH 240
            ..|.::::|........||:..::..|.:||:||:..||:||||||.|.|:.| .|::..||.:.
  Fly   343 SGGFFVENLFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHI-LSDQQTDGGVF 406

Mouse   241 V-RMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGK--STHVPYRNSKL 302
            : :.||::.|||||||...||.:.|:.|:||..||.||..||..||:|.|.|  :.|:|||:|:|
  Fly   407 LSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQL 471

Mouse   303 TRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEI 367
            |:||.|||.||..|:|.|.:.||.||:.||::|||||:|||.|:.|..|..||::||:...:::|
  Fly   472 TKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREALILSLKRDI 536

Mouse   368 EELKKKLEEGEEVSGSDISGSEEDDEEGELGEDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLP 432
            ..|                         ::..|..|........::.:.....:::|..||
  Fly   537 HAL-------------------------QMENDHLKAALNLHHQAAPNGGPVENLLELQLD---- 572

Mouse   433 HQAGKKKVS-----PDKMVEMQ--AKIDEERKALETKLDM-EEEERNKARAELERREKDLLKAQQ 489
                  :||     |...|::|  .::|....|...||.| |.|...:....|....:.:|:.|:
  Fly   573 ------RVSSGGGVPVPKVDLQRLPELDGSELAELVKLYMVENESLRQENNHLFTVRETILRDQE 631

Mouse   490 ----EHQSLLEKLSALEKKVI------------------VGGVDLLAKAEEQEK-----LLEESN 527
                |::.||:||..:.|..:                  ..|.::....|..:.     |..|..
  Fly   632 IVCRENERLLKKLEDVNKVCVRSPLIPARPAISPTTGKETPGTEIWTNPEPLQSPPGPDLPIEQR 696

Mouse   528 MELEERRRRAEQLRKELEEK-------------EQERLDIEEKYTSLQEEAQGK 568
            |. |...||.:..:|.:::|             .:...||.::.....|||..|
  Fly   697 MS-ENANRRTDTAQKRIDQKRIAKNILIMANAFRKPDSDITKELNLNPEEAHAK 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	138/353 (39%)
		Smc	<450..>614	CDD:440809	32/160 (20%)
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	139/358 (39%)