Protein Alignment Kif3a and sub

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Alignment Length: 626
• Identity: 169/626 - (26%)
• Similarity: 255/626 - (40%)
• Gaps: 190/626 - (30%)

Mouse    16 KVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSS----NEPPKTFTFDTVFGPESKQLDV 76
            :|.:|.||:.:..|:....:..:|     .||..|.||:    |...|.|.|.::|.....|.|:
  Fly    89 QVFLRLRPVKDASKAYIVSEEANV-----LITSCKVDSTSNNVNRMEKHFGFTSIFDSTVGQRDI 148

Mouse    77 YNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEG--VRAVPGLRGVIPNSFAHIF-------- 131
            |:....|   .::|....||..||.:|:|||:|:.|  |||     |:||.:..:||
  Fly   149 YDTCVGP---KIMEEECVTIMTYGTSGSGKTYTLLGDDVRA-----GIIPRALENIFTIYQDTVF 205

Mouse   132 ---------GHI-------------------------------------------AKAEGDTRFL 144
                     |.|                                           .||..|...|
  Fly   206 RSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVIDGDHMFETKASTDVSVL 270

Mouse   145 VRVSYLEIYNEEVRDLLG----KDQTQRLEVKERPDVG----VYIKDLSAYVVNNADDMDRIMTL 201
            |.||::|||||.|.|||.    :|:...:..|....||    |:||.|::..|.::::..|::.|
  Fly   271 VWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNKGHVFIKGLTSVFVTSSEEALRLLRL 335

Mouse   202 GHKNRSVGATNMNEHSSRSHAIFTITI-ECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQ 265
            |.:..:..:|::|.:|||||.:||:.| :.:..|:     .........|||||||...||.:|.
  Fly   336 GQQRSTYASTSVNANSSRSHCVFTVDILKYNRSGI-----TTQSSYKFCDLAGSERVNNTGTSGL 395

Mouse   266 RLKEATKINLSLSTLGNVISA--LVDGKSTH--VPYRNSKLTRLLQDSLGGNSKTMMCANIGPAD 326
            |||||..||.||..||..:.|  .|..|...  :|||:||||.|||.:|.|..|..|...:.|.|
  Fly   396 RLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLD 460

Mouse   327 YNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKE----IEELKKKLEEGEEVSGSDISG 387
            ..|:|.::.|.:|:.||||     |.::|   :::|.:..    :|..|....||.:.:
  Fly   461 KYYEENLNVLNFASIAKNI-----IFKEP---VIKQHRVSYCGFMEFSKMSTCEGGDYT------ 511

Mouse   388 SEEDDEEGELGEDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKKVSPDKMVEMQAKI 452
            .|.:||...|..:.|:.|.                                    |.:::||...
  Fly   512 KELEDENVRLQLEIEQLKY------------------------------------DHVLQMQLLE 540

Mouse   453 DEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAE 517
            ::.|:.| |....|..:.||.:.| :..||.||.||:|.:.:|.
  Fly   541 EKLRREL-TATYQEIIQNNKKQYE-DECEKKLLIAQRESEFMLS--------------------- 582

Mouse   518 EQEKLLEESNMELEERRRRAEQ---LRKELEEKEQERLDIE 555
                         .:|||..||   |:.|:||.:....|.:
  Fly   583 -------------SQRRRYEEQIEDLKDEIEELKNPASDTD 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	126/407 (31%)
		Smc	<450..>614	CDD:440809	25/109 (23%)
sub	NP_611260.1	KISc	89..477	CDD:276812	124/405 (31%)
		GBP_C	<512..603	CDD:293879	33/162 (20%)
		coiled coil	576..586	CDD:293879	2/43 (5%)
		coiled coil	592..603	CDD:293879	4/10 (40%)