Protein Alignment Kif3a and Klp98A

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 869
• Identity: 245/869 - (28%)
• Similarity: 369/869 - (42%)
• Gaps: 293/869 - (33%)

Mouse    14 NVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHK----TDSSNEPPKTFTFDTVF------G 68
            ::||.||.||.|.||..|..:..:.::..:..:...:    .|:..:....||||..:      .
  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67

Mouse    69 PE-SKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFG 132
            |. :.|..||:.....::|...||||..:|||||||:||||||.|....|||   ||.....:|.
  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGL---IPRICEELFA 129

Mouse   133 HI-AKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQT-QRLEVKERPDVGVYIKDLSAYVVNNADDM 195
            .: ...|..|.:....||||||||.|:|||....| ..|.|:|...:|.|:::||.:.|::.|::
  Fly   130 RMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEI 194

Mouse   196 DRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKT 260
            ...:..|:..|:..:||||:.|||||||||||. .....::......:.|:||||||||||...|
  Fly   195 QECIARGNAQRTTASTNMNDTSSRSHAIFTITF-VQAVFMNDMPSETVSKIHLVDLAGSERANAT 258

Mouse   261 GATGQRLKEATKINLSLSTLGNVISALVD------------------GKS---THVPYRNSKLTR 304
            |||||||||...||.||.|||:|||||.:                  |.|   .::|||:|.||.
  Fly   259 GATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTW 323

Mouse   305 LLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEE 369
            ||:|||||||||:|.|.:.|||.||.||:||||||||||||.||..:|||....|:|:.::||.:
  Fly   324 LLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINK 388

Mouse   370 LK--------------------KKLEEGEEV--------------------------SG------ 382
            ||                    :|.|..|:|                          ||
  Fly   389 LKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLD 453

Mouse   383 ----------SDIS---------------GSEEDD--EEGELGEDG------------------- 401
                      :|::               |||:.|  ::.||..||
  Fly   454 SEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHP 518

Mouse   402 ---------------------------------------EKKKKRRGSSSS-----------SSS 416
                                                   |..|.|:..|.|           ||.
  Fly   519 WPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSK 583

Mouse   417 DS--TCSVIEKPLDEFLPHQAGKKKVSPDKMV-----EMQAKIDEERKALET-----------KL 463
            ::  |||:.... |...|::..:::..|.:.:     |:|   ||.||.|:|           ::
  Fly   584 ENLLTCSIYSDE-DGASPYKRPERQYYPQRPMSRDDPELQ---DENRKILDTIENALKQLNVERV 644

Mouse   464 DMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVG-------------GVDLLAK 515
            .|.::.:.|.|    :..::|::.:||....|:.|:..|:::|..             .:|::.:
  Fly   645 QMHDQYKTKVR----KLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCR 705

Mouse   516 --------------------AEEQEKL-----LEESNMELEER---------------------- 533
                                |:|.::|     |:|..|::||.
  Fly   706 QISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQF 770

Mouse   534 -----RRRAEQLRKELEEK--EQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQ 591
                 ||..|::|| |:|:  |:||:            ....|.|:.||...::..::::..|:.
  Fly   771 IKDTVRRNNEEIRK-LDEQIAEKERI------------LNASTTKIAKVDETMLEIQAQLERLRL 822

Mouse   592 EHQREIEGLLENIRQLSRELRLQM 615
            | :.|.|...:.:|...:.::||:
  Fly   823 E-RAESEAESQAMRAKKQNMKLQL 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	156/364 (43%)
		Smc	<450..>614	CDD:440809	44/241 (18%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	160/371 (43%)
		Kinesin_assoc	370..478	CDD:465047	16/107 (15%)
		FHA_KIF16	449..556	CDD:438760	9/106 (8%)
		SMC_N	624..>864	CDD:481474	45/240 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784