Protein Alignment Kif3a and Kif19A

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Alignment Length: 727
• Identity: 203/727 - (27%)
• Similarity: 326/727 - (44%)
• Gaps: 153/727 - (21%)

Mouse     8 KPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESK 72
            :|...:.:.|.||.||..|..: .|      ::.:.|...:: .|.....|:.:::|.||.....
  Fly    29 QPAQEERLVVAVRVRPSMEATE-RC------IEVISGGSLLY-DDGGKSRPRQYSYDHVFRENDS 85

Mouse    73 QLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGV----------RAVPGLR------- 120
            |..||..|..|::..||.|.|..:||||.||:|||.||.|.          ||.|...
  Fly    86 QEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDSTDVS 150

Mouse   121 ----GVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYI 181
                |::..:...||.||..||..: ..|.:||||||||.:||||.......|....|.. .:.:
  Fly   151 SQDIGLMVRAIEDIFSHIESAEAYS-CRVSISYLEIYNELIRDLLNPGGPLELREDHRGQ-RITV 213

Mouse   182 KDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKL 246
            ..||....::..::..::..|:|.|::..|..|:.||||||:.:|.::....     :..:.|:|
  Fly   214 AGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTP-----LGTKQGRL 273

Mouse   247 HLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLG 311
            .|.|||||||..||...|:||:|...||.||..|||||:.| .|.:.:|.||:|||||||:::|.
  Fly   274 FLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGL-SGGARYVNYRDSKLTRLLKEALS 337

Mouse   312 GNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARIN---EDPKDALLRQFQKEIEELKKK 373
            |..||:|.|::.|...:.|||.:||.||:||.:|..|.:.:   ::.||...:.:|..:.||:
  Fly   338 GRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKHYQSLVSELR-- 400

Mouse   374 LEEGEEVSGSDISGSEEDDEEGELGEDGEKKKKRRG------SSSSSSSDSTCSVIEKPLDEFLP 432
                              ||...|......::.|.|      ::::|.|..|..
  Fly   401 ------------------DEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAG----------- 436

Mouse   433 HQAGKKKVSPDKMVEMQAKIDEERKA----LETKLDMEEEERNKARAELERREKDL----LKAQQ 489
            ..||.:.|...         ||:||.    |..::.:..:::.|.|.:|...|..|    |.|::
  Fly   437 SGAGSEAVQEQ---------DEQRKTELRYLREQIVLTFKQQMKLRRKLLEAESHLLGLELDAER 492

Mouse   490 EH------QSLLEKL------SALEKKVIVGGVDL------LAKAEEQ----EKLLEESNMELEE 532
            :|      |..:.||      ..:|.:   |.|.|      ||..|::    :::.|.:..|||:
  Fly   493 QHMIISHWQGRIGKLYDAMGDDDIESE---GSVALKNAWGELAAIEKETRRYKEIRERTEHELEQ 554

Mouse   533 RRRRAEQLRKELEEK-----EQERL-------DIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSE 585
            .|::..:|..||.|:     |:|.|       ::|....|||.|...:..:|:         :.:
  Fly   555 CRQKGVKLEDELPERISSDEERELLALLCRVHELEADKVSLQAERLARQAELR---------RRD 610

Mouse   586 MADLQQEHQREI-EGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVA 649
            :..|:.|.||.: |.::.:.|:|..|..:.       :|.:.:|:   |..:.::|....:  ..
  Fly   611 LQLLRAERQRRLCEDIISSQRRLIEEGNVD-------LPDELREL---YGLYQQEIHAGVV--TP 663

Mouse   650 YTGNNMRKQTPV 661
            .|.|..||..|:
  Fly   664 STSNYERKLPPI 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	126/352 (36%)
		Smc	<450..>614	CDD:440809	49/206 (24%)
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	126/351 (36%)
		SMC_prok_B	<393..672	CDD:274008	70/342 (20%)