Protein Alignment Kif3a and Klp68D

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 736
• Identity: 291/736 - (39%)
• Similarity: 444/736 - (60%)
• Gaps: 72/736 - (9%)

Mouse     6 SEKPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHK-TDSSNEPPKTFTFDTVFGP 69
            |:.|..|  |:|||||||::.||:|....:.|:|...||.:.:.. .|.:.|..|.||:|..:..
  Fly    13 SQTPNEC--VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDA 75

Mouse    70 ESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHI 134
            .:.|..:|:....|::.|||||:||.|||||||||||||||||||....|.|:||.:|..|:.||
  Fly    76 SATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI 140

Mouse   135 AKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIM 199
            .:.| :.:|||.|||||||.||:|||| |..::.|||:||.. |||:.:|.|....:.:||.::|
  Fly   141 NRTE-NFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRERGS-GVYVPNLHAINCKSVEDMIKVM 202

Mouse   200 TLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATG 264
            .:|:|||:||.||||||||||||||.|.||..:...:   .:::|||:|:||||||||:||||:.
  Fly   203 QVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETN---TIKVGKLNLIDLAGSERQSKTGASA 264

Mouse   265 QRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNY 329
            :|||||:||||:||:||||||||.: .|.|||||:|||||||||||||||||:|.|||||::|||
  Fly   265 ERLKEASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNY 328

Mouse   330 DETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEE 394
            :||::|||||:|||:|:|:...||||:||.|:::|:|||.||:.:...::         :..:::
  Fly   329 NETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKRLIGPQQQ---------QRSEKQ 384

Mouse   395 GELGEDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKKVSPDKMVEMQAKIDEERKAL 459
            ....:...||.|:...:...|.....|.||:|:::                       |.:.:..
  Fly   385 VTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVED-----------------------DSDPEGA 426

Mouse   460 ETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLE 524
            |::.|.|.|      ||:.:..::|.:.:.|:..|..||:.||.:::.||.:||....|::..||
  Fly   427 ESESDKENE------AEVAKSNEELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQIELE 485

Mouse   525 ESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADL 589
            :..:|:.||::|..:::::||.:|:..|:|.|:..||::|.:.|.:||.|.:...:|.:.|:.|.
  Fly   486 KKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQELNDC 550

Mouse   590 QQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYT--- 651
            :.:|.:::..|.....:|.:||:.|:||||||:|.:.::.:.....::|:..||:...::..
  Fly   551 KSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLPTPP 615

Mouse   652 --GNNMRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSL---------MKLERP-RTSKGKAR 704
              ......:.||...:.|.|    .|...|...:.:...||         .:||.| ||::....
  Fly   616 GGDGKFSSKRPVSHPQRRRP----TSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQEYRT 676

Mouse   705 PKMGRRKRSAKPETVIDSLLQ 725
            ||:     ||..:.|:...:|
  Fly   677 PKV-----SASLQAVLAQAMQ 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	189/332 (57%)
		Smc	<450..>614	CDD:440809	46/163 (28%)
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	191/337 (57%)
		Smc	<431..>580	CDD:440809	47/154 (31%)