Protein Alignment Kif3a and Klp67A

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 816
• Identity: 217/816 - (26%)
• Similarity: 339/816 - (41%)
• Gaps: 216/816 - (26%)

Mouse    10 ESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNE--------PPK------- 59
            |...|:||.||.||.|.||.....|..:.|.: |..:.....:..:|        |.:
  Fly     4 EQHTNIKVAVRVRPYNVRELEQKQRSIIKVMD-RSALLFDPDEEDDEFFFQGAKQPYRDITKRMN 67

Mouse    60 ---TFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRG 121
               |..||.||..::...|::.....|::|:||.|||.::|.||.||.||||||.|..|.|||..
  Fly    68 KKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTY 132

Mouse   122 VIPNSFAHIFGHIAKAEGDTR-FLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLS 185
            :   :...:|..| :|:.|.| |.|.|||||:|||.|.:||.|....:|   ...:.||.:..|.
  Fly   133 L---TMQDLFDKI-QAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKL---REDNNGVVVSGLC 190

Mouse   186 AYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVD 250
            ...:.:|:::.|::.||:.:|:...|:.|..||||||||.:.|..:|:..|..   |..||.::|
  Fly   191 LTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTK---RTVKLSMID 252

Mouse   251 LAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSK 315
            ||||||.|.|...|.|.||...||.||..|||.|:.|.||.. |:|||:|.|||:|:||||||.:
  Fly   253 LAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLK-HIPYRDSNLTRILKDSLGGNCR 316

Mouse   316 TMMCANIGPADYNYDETISTLRYANRAKNIK--------------------------NKARINE- 353
            |:|.||:..:...|::|.:||:||:|||.|:                          ...|:.|
  Fly   317 TLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKER 381

Mouse   354 -------------------DPKD------------ALLRQFQKEI-------------EELKKKL 374
                               ||.:            |..||.|:.:             :.|||:|
  Fly   382 NKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINYRQTLKKEL 446

Mouse   375 EEGEEVSGSDISGSEEDDEEGELGEDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKK 439
            ||..::...|....:||              .||.::..|   :..|.:||..:| ||....|.:
  Fly   447 EEFRKLMCVDQRVCQED--------------FRRFANYMS---TLTSQMEKYKEE-LPSWLSKME 493

Mouse   440 VSPDKMVEMQAKIDEER-----------KALETKLDMEEEERNKARA---------ELER----- 479
            ::...:..::.::::.:           |.||.:|..:....|...|         :|.|
  Fly   494 IAYQDLESLKREVNKSKAYQILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRT 558

Mouse   480 ----------REKDLLKAQQEHQSLLEKL-------------SALEKKVIVGGVDLLAKAEEQEK 521
                      |.:|..|...|.:::.|:|             ...|...:...|.|.:.|:|:|:
  Fly   559 ACEVLNQTYDRLEDGQKLTPEIEAVFERLLRKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEE 623

Mouse   522 LLEESNMELEERRRRAEQLRKELE------EKEQERLDIEEKYTSLQ---------------EEA 565
            .........::|:|:|.|...:|.      :.:....|.||.:.:.:               ..:
  Fly   624 PTCSLTASAKKRQRQAAQSDDDLHLSMEDFDSQDTESDSEELHRTFKRPRNLNETQVLGPCSSSS 688

Mouse   566 QGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLL--ENIRQLSRELRLQMLIIDNFIPQDYQE 628
            ...|.........|.|..::...:|   ||.:..|:  :|:|..:.:::..:|..::|..|..|.
  Fly   689 SSSTSSSSSARKALTATVTKPRTVQ---QRLVSDLISDQNVRGGNEKIKKALLKSNHFTAQGLQR 750

Mouse   629 MI-------ENYVHWNEDIGEWQLKCVAYTGNNMRK 657
            .:       ||               |.|..|.:||
  Fly   751 TLAAASLAKEN---------------VKYNANYVRK 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	140/350 (40%)
		Smc	<450..>614	CDD:440809	37/234 (16%)
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	140/349 (40%)