Protein Alignment Kif3a and Klp64D

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_523934.1
• Gene: Klp64D / 38611
• FlyBaseID: FBgn0004380
• Length: 677
• Species: Drosophila melanogaster
• Alignment Length: 707
• Identity: 397/707 - (56%)
• Similarity: 504/707 - (71%)
• Gaps: 52/707 - (7%)

Mouse    10 ESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTD-SSNEPPKTFTFDTVFGPESKQ 73
            :..:||:||||.||:::.|.|.....|:|||::...|||.|.: ::||||||:.||.||...|.|
  Fly    16 DEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFDGGSNQ 80

Mouse    74 LDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAE 138
            :|:|..|||||:|.|||||||||.||||||||||:||.|....|..:|:|||:|||||||||||:
  Fly    81 MDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGHIAKAK 145

Mouse   139 GDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGH 203
            .:.:|||||||:||||||||||||||..:.||||||||:||::||||.|||:||||::.||.||:
  Fly   146 ENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEVKERPDIGVFVKDLSGYVVHNADDLENIMRLGN 210

Mouse   204 KNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLK 268
            |||:||||.||:.||||||||:||:|.||.|.....|||||||.||||||||||:||.|:|||||
  Fly   211 KNRAVGATKMNQESSRSHAIFSITVERSELGEGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLK 275

Mouse   269 EATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETI 333
            ||||||||||.|||||||||||||||:|||||||||||||||||||||:|||.|.|||.||.|||
  Fly   276 EATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMCATISPADSNYMETI 340

Mouse   334 STLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEEGELG 398
            ||||||:|||||:|:..|||:|||||||.||:||..|:|:||||:.:.....|..||:|
  Fly   341 STLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLEEGDSLEEEPPSSEEEED------ 399

Mouse   399 EDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKKVSPDKMVEMQAK----IDEERKAL 459
                           ::.|.    :|.||:                 :|:::.    ::::.|..
  Fly   400 ---------------TADDE----LEAPLE-----------------IELESSTIQAVEKKPKKK 428

Mouse   460 ETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLE 524
            ..|.|.|:||..|.:.|   .:|::..|:.|.::|..||.:||.|::|||.:||.||:.||.|||
  Fly   429 REKTDAEKEELAKRKNE---HQKEIEHAKTEQETLRNKLVSLEGKILVGGENLLEKAQTQELLLE 490

Mouse   525 ESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADL 589
            :|..|||:..:..|.|::.|::|..||:||||:|::||:.:.|.|||:.:|..|||..|||:||.
  Fly   491 QSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQ 555

Mouse   590 QQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNN 654
            |||||||.||:.||||.|||||.|..|::::::|::||.||..|.||||||||||||||||||||
  Fly   556 QQEHQREKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNN 620

Mouse   655 MRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSL-MKLERPRTSKGKARPKMGRR 710
            |||.........::|..:|||||||:|..:.:...: .|..||||| |..||...||
  Fly   621 MRKHISAHKTSGKEPDFLDLSHVYLSYNTDGVSNPMRSKSARPRTS-GVPRPTTARR 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	237/332 (71%)
		Smc	<450..>614	CDD:440809	77/167 (46%)
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	237/332 (71%)
		Smc	<433..>578	CDD:440809	74/147 (50%)