Protein Alignment Kif3a and Klp61F

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Alignment Length: 763
• Identity: 244/763 - (31%)
• Similarity: 392/763 - (51%)
• Gaps: 91/763 - (11%)

Mouse     4 NKSEKPE--SCDNVKVVVRCRPLNEREKSMCYRQAVSVDEM--RGTITVHKTDSSNEPPKTFTFD 64
            |.|.:|:  |..|::|.||.||||.||:  |.|.|..||.:  |..:|.|..||  :..|.||||
  Fly     7 NTSRQPQKKSNQNIQVYVRVRPLNSRER--CIRSAEVVDVVGPREVVTRHTLDS--KLTKKFTFD 67

Mouse    65 TVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLR--------- 120
            ..|||||||.|||::...|:|:.||.|||.|:|||||||||||.||.| .....|:
  Fly    68 RSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVG-NETAELKSSWEDDSDI 131

Mouse   121 GVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEV--KERPDVGVYIKD 183
            |:||.:.:|:|..:...|  ..:.:|:||||:||||:.|||..|.|.::.:  .......|.|:.
  Fly   132 GIIPRALSHLFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQG 194

Mouse   184 LSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHL 248
            |....|::.||:.:::..|.:.|....|.||..|||||.:|:|.:...|.|::|...:::|||:|
  Fly   195 LEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNL 259

Mouse   249 VDLAGSERQAKTG-ATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGG 312
            |||||||..:|.| ..|.|::|...||.||.|||.||:|||| ::.|||||.||||||||:||||
  Fly   260 VDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGG 323

Mouse   313 NSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINED-PKDALLRQFQKEIEELKKKLEE 376
            .:||.:.|.|.|...:.:||:|||.||:|||||:||..:|:. .|..:|:::.:||::||:.|..
  Fly   324 RTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMA 388

Mouse   377 GEEVSGSDISGSEEDDEEGELGEDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKKVS 441
            ..:.:|..::    ::..||:....|.:.:.....         .::.|.|.:.|.:   |:|:.
  Fly   389 ARDKNGIYLA----EETYGEITLKLESQNRELNEK---------MLLLKALKDELQN---KEKIF 437

Mouse   442 PDKMVEMQAKIDEERKALETKLDMEEE--ERNKARAELERREKDLLKAQQEHQSLLEKLSALEKK 504
            .:..:.:..|..|.:|..|..|:.:..  ...|...:.:||.|:..:....|.. .|::...:.:
  Fly   438 SEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMK-TEQVLTTQAQ 501

Mouse   505 VIVGGVDLLAKAEEQEKLLEESNMELEER-RRRAEQLRKELEE-------------------KEQ 549
            .|:...||......|.....|...||:|: ||..:|.:..:::                   |||
  Fly   502 EILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQ 566

Mouse   550 ERLD-IEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADL------------QQEHQREIEGLL 601
            ...: :...|.| |..|...:|.::.:..|...:..:..:|            .|..|..:..|:
  Fly   567 LSQEMVNSSYVS-QRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLM 630

Mouse   602 ENIRQ----LSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQ---- 658
            |.::|    :|:|::..:.:|:. ..|.::.|:::.......|.:..|:.|......|.|:
  Fly   631 EQMQQQQLLMSKEIQTNLQVIEE-NNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQL 694

Mouse   659 --TPVPDKKERDPFEVDLSHV-YLAYTEESLRQS-LMKLERPRTSKGK 702
              ..:||.:|....:.:|::. .||..|::|.:| :|::|:.:..:.|
  Fly   695 GAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSK 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	160/345 (46%)
		Smc	<450..>614	CDD:440809	39/202 (19%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	165/355 (46%)
		SMC_prok_B	<408..728	CDD:274008	61/334 (18%)
		SMC_prok_B	<651..>921	CDD:274008	20/93 (22%)
		Microtub_bind	923..>1004	CDD:464048