Protein Alignment Kif3a and unc-104

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Alignment Length: 719
• Identity: 238/719 - (33%)
• Similarity: 343/719 - (47%)
• Gaps: 125/719 - (17%)

Mouse    14 NVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKT------FTFDTVFGPE-- 70
            :|||.||.||.|.||.:   |::..:.||.|..|.  ..:...||.|      |.||..:...
  Fly     3 SVKVAVRVRPFNSREIA---RESKCIIEMAGATTA--ITNPKVPPNTSDSVKRFNFDYSYWSHDH 62

Mouse    71 -----SKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHI 130
                 |.|..||......::....:|||..||||||||.||::||.| |......|:||.....:
  Fly    63 HDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMG-RQEEQQEGIIPMICKDL 126

Mouse   131 FGHIAKAE-GDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADD 194
            |..|...| .|.::.|.|||:|||.|.|||||.......|.|:|.|.:|.|::|||...|.:..|
  Fly   127 FTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQD 191

Mouse   195 MDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHV-RMGKLHLVDLAGSERQA 258
            :..::..|:|.|:|.||||||.||||||:|||........:..|:.. ::.|:.|||||||||..
  Fly   192 IHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEKVSKISLVDLAGSERAD 256

Mouse   259 KTGATGQRLKEATKINLSLSTLGNVISALVD--------GKSTHVPYRNSKLTRLLQDSLGGNSK 315
            .|||.|.||||...||.||:|||.|||||.:        .|:..:|||:|.||.||:::||||||
  Fly   257 STGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSK 321

Mouse   316 TMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLE-EGEE 379
            |.|.|.|.|||.|||||:||||||:|||.|..||.:|||....|:|:.::||::|:..|: ||.|
  Fly   322 TAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIE 386

Mouse   380 VSGSDISGSEEDDE--EGELGEDGEKKKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKKVSP 442
            |        :|:||  :..:.:...|.:.|.||::..:.|. ....||.:.|.......|.|.:.
  Fly   387 V--------QEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQ-LQASEKLIAELNETWEEKLKRTE 442

Mouse   443 DKMVEMQAKIDEERKALE--------------------------------------TKLDMEEEE 469
            :..|:.:|...|...|::                                      |:|...|.
  Fly   443 EIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEA- 506

Mouse   470 RNKARAELERREKDLLKAQQEHQSLLEKLSAL------EKKVIVGGVDLLAKAEEQEKLLEESNM 528
              ....:::.....:||   ||.:...|.|.:      :..:.|.|    .|..|.|.|...|.:
  Fly   507 --NVPQDIQLSGSHILK---EHCTFENKNSTVTLLPHKDAIIYVNG----RKLVEPEVLKTGSRV 562

Mouse   529 ELEERR-------RRAEQLRKELE-----EKEQERLDIEEKYTSLQE----EAQG---KTKKLKK 574
            .|.:..       .:|.:||.::|     |.|.|:.|.::...:..:    |.||   |.:..|:
  Fly   563 ILGKNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKR 627

Mouse   575 VWTMLMAAKSE--MADLQQEHQRE-IEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHW 636
            :..:....|.|  .||.|.|.||: .|..::.:::...|..:.|.:..::.|:|:        |.
  Fly   628 LDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDF--------HQ 684

Mouse   637 NEDI 640
            .||:
  Fly   685 EEDV 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	159/353 (45%)
		Smc	<450..>614	CDD:440809	43/229 (19%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	162/360 (45%)
		Kinesin_assoc	355..498	CDD:465047	31/151 (21%)
		FHA_KIF1	474..574	CDD:438757	17/109 (16%)
		YhaN	<575..>666	CDD:443752	22/90 (24%)
		KIF1B	878..924	CDD:463574
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939