Protein Alignment Kif3a and Khc-73

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Alignment Length: 818
• Identity: 242/818 - (29%)
• Similarity: 355/818 - (43%)
• Gaps: 237/818 - (28%)

Mouse    13 DNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEP---------PKTFTFDTVF- 67
            |.:||.||.||.|.||..:..:..|.:::       .:|...|.|         ||||.||..|
  Fly     4 DKIKVAVRVRPFNRREIELDTKCIVEMEK-------QQTILQNPPPLEKIERKQPKTFAFDHCFY 61

Mouse    68 --GPE----SKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNS 126
              .||    :.|..|::...|.|:|:..:|||..||||||||:||::||.|.:.   .:|:||..
  Fly    62 SLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE---SKGIIPRL 123

Mouse   127 FAHIFGHIA-KAEGDTRFLVRVSYLEIYNEEVRDLLG-KDQTQRLEVKERPDVGVYIKDLSAYVV 189
            ...:|..|| |:..:..:.|.|||:|||||:|.|||. |...|.|:|:|...:|.|:..||...|
  Fly   124 CDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAV 188

Mouse   190 NNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTIT----IECSEKGVDGNMHVRMGKLHLVD 250
            .:..|:|.:||.|:|:|:|.|||||..||||||:|::.    :.....||.|.   ::.::.|||
  Fly   189 TSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE---KVSRMSLVD 250

Mouse   251 LAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVD-------GKSTHVPYRNSKLTRLLQD 308
            ||||||..||||.|.||||.:.||.||:|||.|||.|.|       |....||||:|.||.||:|
  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315

Mouse   309 SLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKK- 372
            :|||||:|:|.|.|.|:..||:||:||||||:|||.|.|.|.:||||...::|:.:.|:|.|:.
  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM 380

Mouse   373 --------------KLEEGEE-------------------------------------------- 379
                          ||.|.|.
  Fly   381 LKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKN 445

Mouse   380 --------------------------VSGSDISGSEEDDEEGELG----------EDG------- 401
                                      :.|..|||.:.|.:...||          ||.
  Fly   446 KYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPV 510

Mouse   402 -------------EKKKKRRG-------------SSSSSSSDSTCSVIEKPLDEFLPHQAGKKKV 440
                         ||...:.|             :|..|::.|.|:  .:|.   .|.|......
  Fly   511 QGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCA--SEPQ---TPAQLIDYNF 570

Mouse   441 SPDKMVEMQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKV 505
            :.|::::.:...|..:.|: .:|:.:.||..:...|.:|:|     .:::.|.|...||......
  Fly   571 ARDEIMQNELSNDPIQTAI-ARLERQHEEDKQVALEKQRQE-----YERQFQQLRNILSPSTPYA 629

Mouse   506 IVGGVDLLAK-----------------AEEQEKLLEESNMELEERRRRAEQ-------LRKELEE 546
            .....|.|..                 |:|::::...|..:|:....||..       |.:|:|:
  Fly   630 PYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEK 694

Mouse   547 KEQERLDIEEKYTSLQEEAQ------------GKTKKLKKVWTM--LMAAKSEMADLQQEH-QRE 596
            |.:..:.::....:|....:            .:|....::|||  |.....:|.::.||| :|.
  Fly   695 KTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERV 759

Mouse   597 IEGLLENIRQLSRELRLQMLIIDNFIPQD-YQEMIENY 633
            :.||.|                ||..||| :.|..||:
  Fly   760 LNGLDE----------------DNAKPQDPFYESQENH 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	161/360 (45%)
		Smc	<450..>614	CDD:440809	38/202 (19%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	164/367 (45%)
		Kinesin_assoc	356..468	CDD:465047	13/111 (12%)
		FHA_KIF13	446..547	CDD:438758	12/100 (12%)
		KIF1B	741..786	CDD:463574	17/57 (30%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154