Protein Alignment Kif3a and Klp31E

DIOPT Version :10

• Sequence 1: XP_006532388.1
• Gene: Kif3a / 16568
• MGIID: 107689
• Length: 725
• Species: Mus musculus
• Sequence 2: NP_609398.2
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Alignment Length: 684
• Identity: 219/684 - (32%)
• Similarity: 338/684 - (49%)
• Gaps: 108/684 - (15%)

Mouse     3 INKSEKPESCDNVKVVVRCRPLNEREK-SMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTV 66
            |||.      .:|:|.||.||.|.||. .||        .:..|:|:.:........|.||||.|
  Fly     8 INKD------SSVRVAVRIRPQNSRELIDMC--------RICTTVTLGEPQIFLGSDKAFTFDYV 58

Mouse    67 FGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTM------EGVRAVPGLRGVIPN 125
            |...|.|.|:|:.....::||.|.|||.|:.||||||:|||:||      |...:.....|:||.
  Fly    59 FDTNSNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPR 123

Mouse   126 SFAHIFGHIAKAEGDT-----------RFLVRVSYLEIYNEEVRDLLGK-DQTQRLEVKERPDVG 178
            :..|||..|.:.||.:           :|.:.|.|:|:|||::.|||.. ::....::.|.....
  Fly   124 AVRHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQ 188

Mouse   179 VYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIE------CSEKGVDG 237
            :.|...|...:....|..:.:..|...|:..:|.||:.||||||:|||.:.      .|:...|.
  Fly   189 ITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVPDN 253

Mouse   238 NMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVD--GKSTHVPYRNS 300
            ::.....|.|.||||||||..:|.|||:|.:|...||..|..|||.||||.|  .::.|||||:|
  Fly   254 DLETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALHVPYRDS 318

Mouse   301 KLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQK 365
            ||||||||||||||:|:|.|.:.|:|.::.||::||:|||||:|||||.:||:|.....:.|.::
  Fly   319 KLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTISQLRR 383

Mouse   366 EIEELKKKL---EEGEEVSGSDISG----SEEDDEEGELGEDGEKKKKRRGSSSS---------- 413
            ||..|:.:|   ::|:.:  .|..|    |:..:|...|..:.::.::|..|..|
  Fly   384 EIAALQLELLEYKQGKLI--VDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQRNA 446

Mouse   414 -----------SSSDSTCSVIEKPLDEFLPHQAGKKKVSPDKMVEMQAKI---DEERKALETKLD 464
                       :|.|::...|.|.:.:::.           ::.|:|.|:   :|.||.:|.|
  Fly   447 DLKTNLDLNKWTSDDNSDVEIAKVVGQYML-----------EIEELQTKLIESEEHRKQMEIK-- 498

Mouse   465 MEEEERN-----------KARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEE 518
            .....||           ||:.:|| ||::||.::.......:.:|:.|.:|....    ::|||
  Fly   499 ATTSPRNAKPVYDSDIITKAKKDLE-RERELLMSRSLPGIQNQNVSSEETEVASSD----SEAEE 558

Mouse   519 QEKLLEESNMELEERRRRAEQLRKELEEKEQERLDIEEK----YTSLQEEAQGKTKKLKKVWTML 579
            ..|.||..:.::|.|.:..|||.......||.|...|||    |..::...:.:...|..:.|.:
  Fly   559 VVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLANMTTSV 623

Mouse   580 MA-AKSEMADLQQEHQREIEGLLENIRQLSRELR 612
            .. :|..:..::.:::.:|..:...||:|....|
  Fly   624 STPSKDSLKKVKTDYESKISHMQTEIRKLQNAQR 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3a	XP_006532388.1	KISc_KIF3	13..345	CDD:276822	143/358 (40%)
		Smc	<450..>614	CDD:440809	45/182 (25%)
Klp31E	NP_609398.2	KISc_KIF4	12..364	CDD:276823	144/359 (40%)
		Mplasa_alph_rch	<372..>748	CDD:275316	66/306 (22%)
		SMC_prok_B	622..>899	CDD:274008	6/36 (17%)
		Rcc_KIF21	798..870	CDD:410202