DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kif21a and Klp54D

DIOPT Version :10

Sequence 1:XP_017171930.1 Gene:Kif21a / 16564 MGIID:109188 Length:1685 Species:Mus musculus
Sequence 2:NP_001303355.1 Gene:Klp54D / 47216 FlyBaseID:FBgn0263076 Length:760 Species:Drosophila melanogaster


Alignment Length:604 Identity:188/604 - (31%)
Similarity:281/604 - (46%) Gaps:118/604 - (19%)


- Green bases have known domain annotations that are detailed below.


Mouse    23 RIRPQLAKEKIEGCHICTSVTPGEPQVFL-GKD------------KAFTFDYVFDIDSQQEQIYT 74
            |:||...|||.:. |..|...||..||.| |.|            :.||::.||:..:.||.|..
  Fly   172 RVRPLNDKEKRDR-HGSTLQFPGNGQVILEGNDVGQKRSHNRDSVRVFTYNVVFEPGATQEDILD 235

Mouse    75 QC-IEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDV-----NIMEEEQGIISRAVRHLFKSI 133
            .. |:::||...||::.|.|.|||||:|||:|:....|:     |..:...|:|.|:..:||:.|
  Fly   236 YSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRHGLIFRSFLYLFQLI 300

Mouse   134 DEKKTSAIKNGLPPPEFKVNAQFLELYNEEVLDLFDTTRDIDAKNKKSNIRIHEDSTGGIYTVGV 198
            ..:|         ...:.:.|.|:|:|||.|:||.:.    .:..|...:|..:.| ||.:...:
  Fly   301 KNRK---------DVNYVLKASFMEIYNERVIDLLNP----GSARKPLAVRWSKKS-GGFFVENL 351

Mouse   199 TTRTVNTEPEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQTDAENATDNKLIS 263
            .|.......:::..|:.|..:|...|..||..|||||.|.|:|:...:   |||.          
  Fly   352 FTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHILSDQ---QTDG---------- 403

Mouse   264 ESSPMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATH 328
                 ..|.:...|.:||||||||..|:|.:.|:..:|..:||..|:.||..||:|.|..||..|
  Fly   404 -----GVFLSKHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGH 463

Mouse   329 VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQ 393
            :|||||:||:||.|||.||..|:|||||||:..:..||||||:||:||:.|:.|.::..|.....
  Fly   464 IPYRDSQLTKLLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREAL 528

Mouse   394 INALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALR 458
            |.:|:.:|..||||            .:.:::..::.|:.|.......||             |.
  Fly   529 ILSLKRDIHALQME------------NDHLKAALNLHHQAAPNGGPVENL-------------LE 568

Mouse   459 ARITQLVSEQANQV----LARAGE-GNEEISNMIHSYIKEIEDLRAK-----------LLESEAV 507
            .::.::.|.....|    |.|..| ...|::.::..|:.|.|.||.:           |.:.|.|
  Fly   569 LQLDRVSSGGGVPVPKVDLQRLPELDGSELAELVKLYMVENESLRQENNHLFTVRETILRDQEIV 633

Mouse   508 ---NENLRKNL---TRATARSPYFSASSAFSPTILSSDKET--IEI--------------IDLAK 550
               ||.|.|.|   .:...|||...|..|.|||   :.|||  .||              :.:.:
  Fly   634 CRENERLLKKLEDVNKVCVRSPLIPARPAISPT---TGKETPGTEIWTNPEPLQSPPGPDLPIEQ 695

Mouse   551 KDLEKLKRKEKKKKKRLQK 569
            :..|...|:....:||:.:
  Fly   696 RMSENANRRTDTAQKRIDQ 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kif21aXP_017171930.1 KISc_KIF4 23..380 CDD:276823 137/375 (37%)
Cast <372..846 CDD:431111 55/236 (23%)
EnvC 650..>865 CDD:443969
Rcc_KIF21A 946..1027 CDD:410204
WD40 1350..1663 CDD:238121
WD40 repeat 1401..1460 CDD:293791
WD40 repeat 1466..1501 CDD:293791
WD40 repeat 1506..1550 CDD:293791
WD40 repeat 1558..1591 CDD:293791
WD40 repeat 1598..1634 CDD:293791
Klp54DNP_001303355.1 KISc 166..520 CDD:214526 139/380 (37%)
Blue background indicates that the domain is not in the aligned region.

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