DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kif21a and Klp98A

DIOPT Version :10

Sequence 1:XP_017171930.1 Gene:Kif21a / 16564 MGIID:109188 Length:1685 Species:Mus musculus
Sequence 2:NP_524532.2 Gene:Klp98A / 43310 FlyBaseID:FBgn0004387 Length:1265 Species:Drosophila melanogaster


Alignment Length:1232 Identity:310/1232 - (25%)
Similarity:518/1232 - (42%) Gaps:320/1232 - (25%)


- Green bases have known domain annotations that are detailed below.


Mouse    52 GKDK--AFTFDY---VFDID----SQQEQIYTQCIEKLIEGCFEGYNATVFAYGQTGAGKTYT-M 106
            |:|.  .|||||   .||.:    :.|||:|:.....:::..:|||||.||||||||:|||:| |
  Fly    47 GRDNHHDFTFDYSYWSFDAEDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMM 111

Mouse   107 GTGFDVNIMEEEQGIISRAVRHLFKSI---DEKKTSAIKNGLPPPEFKVNAQFLELYNEEVLDLF 168
            ||       ....|:|.|....||..:   .|..|.          ::.:|.:||:|||.|.|| 
  Fly   112 GT-------PNNPGLIPRICEELFARMRVGQESGTG----------YRTHASYLEIYNERVKDL- 158

Mouse   169 DTTRDIDAKNKKSNIRIHEDSTGGIYTVGVTTRTVNTEPEMMQCLKLGALSRTTASTQMNVQSSR 233
                 :.|::....:|:.|..:.|.|...::...|:...|:.:|:..|...||||||.||..|||
  Fly   159 -----LAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQECIARGNAQRTTASTNMNDTSSR 218

Mouse   234 SHAIFTIHVCQTRVCPQTDAENATDNKLISESSPMNEFETLTAKFHFVDLAGSERLKRTGATGER 298
            |||||||          |..:....|.:.||:         .:|.|.||||||||...|||||:|
  Fly   219 SHAIFTI----------TFVQAVFMNDMPSET---------VSKIHLVDLAGSERANATGATGQR 264

Mouse   299 AKEGISINCGLLALGNVISALGDK-------------------SKRATHVPYRDSKLTRLLQDSL 344
            .|||..||..|:.||:|||||.::                   |||..::|||||.||.||:|||
  Fly   265 LKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWLLKDSL 329

Mouse   345 GGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSEITRLQ---- 405
            ||||:|||||.:||:|.::.|||:||:|||||:||.||..||:|...:.|..||.||.:|:    
  Fly   330 GGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKLKSMLA 394

Mouse   406 -------------MELMEYKTGKRIIDEEGVES---INDMFHENAMLQTENNNLRVRIKAMQE-- 452
                         .:|.:.:..::::.||..|.   ...:..|...|....:.:.|.:.:...  
  Fly   395 GDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLDSEMPHL 459

Mouse   453 -----------TVDALRARITQLVSEQAN--QVLARAGEGNEEISNMIHSYIKEIEDLRAK---- 500
                       |:.:|:...|::.||.|:  |.:..||:|                 :||:    
  Fly   460 IGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDG-----------------IRAQHCSI 507

Mouse   501 LLESEAVNENLRKNLTRATARSPYFSASSAFSPTILSSDKETI--EIIDLAKKDLEKLKR--KEK 561
            .|:...|..:            |:..|....:..::...|:..  :||.|.:.::.:...  :..
  Fly   508 FLKGGVVTLH------------PWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAA 560

Mouse   562 KKKKRLQKLEESGREERSVAGKDDNADTDQEKKEEKGVSEKENNELDVEENQEVSDHEDEEEEEE 626
            |.:|.|.:.:........:....:|..|.....:|.|.|..:..|......:.:| .:|.|.::|
  Fly   561 KLRKDLSRSQLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMS-RDDPELQDE 624

Mouse   627 DEEEEDDIEG--EESSDESDSESDEKANYQADLANITCE-IAIKQKLIDELENSQKRLQTLKKQY 688
            :.:..|.||.  ::.:.|.....|:   |:..:..:|.| |.::|:.:|.|:....|.|.|   .
  Fly   625 NRKILDTIENALKQLNVERVQMHDQ---YKTKVRKLTEELIRLEQEEMDGLQLLNCREQEL---I 683

Mouse   689 EEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVKCEYEKKLHAMNKELQRLQTAQK--- 750
            ..|.|:|..| .:.:::.|.|.:.:.:.::..:.| |:...||      :.||||.||...|   
  Fly   684 ARKDMLLWEK-NNEKVQIDIVCRQISAFQTQLDSK-KRDFSEY------VAKELQELQDCGKLDE 740

Mouse   751 -----EHARLLKNQ-------------SQYEK--------QLKKLQQDVMEMKKTKVRLMKQMKE 789
                 |....|.::             :|:.|        :::||.:.:.|    |.|::.....
  Fly   741 MGMKIEEGTPLNDELLLQVSDSLDLFAAQFIKDTVRRNNEEIRKLDEQIAE----KERILNASTT 801

Mouse   790 EQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRK-------TEEV------- 840
            :..|...|......::.:|:.::.:.:.:.:.:.|:|:|.::.|..|       |.|.       
  Fly   802 KIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSD 866

Mouse   841 ---------------------TALRRQVRPMSD-----KVAGKVTRK--LSSSE-------SPAP 870
                                 |....|..|:|:     :...:.|||  ||.|.       :..|
  Fly   867 TYETCDTFHTAQSNLSLVSSPTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGP 931

Mouse   871 DTGSSA------ASGEADTSRPGTQQKMR----IPVARVQALPTPTTNGTRKKYQRKGFTGRVFT 925
            .:||.:      .||.|.:..|.:|..|.    ...:|.||:   ..||....|::...|....|
  Fly   932 SSGSGSGSVGIGGSGSAPSCTPSSQAIMSDSGVCLDSRNQAI---LQNGHLNNYKQAVRTSDEDT 993

Mouse   926 -----------SKTARMKWQL--LERRVTDIIMQKMTISNMEADMNRLLRQREELTKRREKLSKR 977
                       |..||....|  |.|::.  ..:.:.:.|:|.|:|:  .|.:|.....:.|.:|
  Fly   994 GSCSSCELGRHSDVARPYCPLHSLRRKIA--AQKALIMKNLETDLNK--AQLDEHIADLQDLQRR 1054

Mouse   978 REKIVKESGEGDKSVANIIEEMESLTANIDYINDSIADCQANIMQ-MEEAKEEGETLDVTAVINA 1041
            ..::.:|          :::.::.|.|:        |.|.|:... ||...|...::..::|::.
  Fly  1055 YIQMEQE----------MLQSVQDLEAH--------AQCCADERSGMERQYELASSIMRSSVMSP 1101

Mouse  1042 CTLTEARYLL------------------DHFLSM------GINKGLQAAQKEAQIKVLEGRL 1079
            .::.|:...:                  :||:::      |..|... .:.|.:|.:.:|:|
  Fly  1102 TSMEESTSQIYSPSMTRSCPSMREFPEGEHFITIPSFVMRGAGKQTH-YEYEVRIALPDGKL 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kif21aXP_017171930.1 KISc_KIF4 23..380 CDD:276823 147/359 (41%)
Cast <372..846 CDD:431111 110/583 (19%)
EnvC 650..>865 CDD:443969 55/286 (19%)
Rcc_KIF21A 946..1027 CDD:410204 16/81 (20%)
WD40 1350..1663 CDD:238121
WD40 repeat 1401..1460 CDD:293791
WD40 repeat 1466..1501 CDD:293791
WD40 repeat 1506..1550 CDD:293791
WD40 repeat 1558..1591 CDD:293791
WD40 repeat 1598..1634 CDD:293791
Klp98ANP_524532.2 KISc_KIF1A_KIF1B 2..371 CDD:276816 150/365 (41%)
Kinesin_assoc 370..478 CDD:465047 18/107 (17%)
FHA_KIF16 449..556 CDD:438760 21/135 (16%)
SMC_N 624..>864 CDD:481474 52/257 (20%)
PX_KIF16B_SNX23 1131..1259 CDD:132784 8/33 (24%)
Blue background indicates that the domain is not in the aligned region.

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