DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kif1b and Khc-73

DIOPT Version :9

Sequence 1:NP_001277924.1 Gene:Kif1b / 16561 MGIID:108426 Length:1816 Species:Mus musculus
Sequence 2:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster


Alignment Length:1956 Identity:564/1956 - (28%)
Similarity:828/1956 - (42%) Gaps:579/1956 - (29%)


- Green bases have known domain annotations that are detailed below.


Mouse     1 MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINP----KNPKEAPKSFSFDYSYWSHTS 61
            |:...:||||||||||.||...::|||::|:...|.:.||    |..::.||:|:||:.::| .:
  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64

Mouse    62 PEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEEL 126
            |||..||||..|::.:|:.:|.:||:|||.|||||||||:||||||||.||..  ||||:||::|
  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESK--GIIPRLCDQL 127

Mouse   127 FEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYT 190
            |..|.:....|:.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192

Mouse   191 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSERA 255
            ||.:||..|||:|||||||||..||||||||::|.||...|..|.:|.||||::|||||||||||
  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257

Mouse   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLG 320
            ..|||.|.|||||:||||||||||.|||.||:..|    .||.....|:|||||||||||::|||
  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSN----GKKSGNDKFVPYRDSVLTWLLKDNLG 318

Mouse   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRA 385
            |||||.|||.:||:..||:|||||||||||||:|..:||:||||||:::|||:.||..|:.:|  
  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSML-- 381

Mouse   386 QGLGDIIDIDPLIDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNS 450
                                          ||                     .|.||       
  Fly   382 ------------------------------KH---------------------ATGSP------- 388

Mouse   451 QVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVA 515
                  |..:|             ::|.|||.::.::::||||||.|||.|:.||:..|.:||::
  Fly   389 ------VGDVQ-------------DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGIS 434

Mouse   516 IREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEH 580
            ::..    |:...|...:|||||.||.::|.|:||:||.....|:..:.::.||.|||..|:.||
  Fly   435 VQAS----GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEH 495

Mouse   581 CLFRSERSNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHPEQARAERE 645
            |:...|.|.     :.:||.:.:..:|||........|::|:||:.|.:|.||.|.|:...... 
  Fly   496 CVITIEDSG-----LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM- 554

Mouse   646 KTPSAETPSEPVDWTFAQRELLEKQ-GIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYES 709
            .....:||::.:|:.||:.|:::.: ..|..|....||:      ::.:|:..:.||:||.:||.
  Fly   555 CASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLE------RQHEEDKQVALEKQRQEYER 613

Mouse   710 KLQALQR---------------QVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQF 759
            :.|.|:.               .:....:...|...:...|:  |.|...|:.:.:..:.|:   
  Fly   614 QFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEK--WAQERDEMFRRSLGQLKT--- 673

Mouse   760 TSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPVPPELLPSEMEKTHEDRPFPRTV 824
                |::..|:: ::|||.::.|::||.:|..     ||..| |..|.|:.........|     
  Fly   674 ----DIMRANSL-VQEANFLAEEMEKKTKFSV-----TLQIP-PANLSPNRRRGAFVSEP----- 722

Mouse   825 VAVEVQDLKNGATHYWSLDKLKQRLDLMREMYDRAGEVASSAQDDSETTMTGSDPFYDRFHWFKL 889
             |:.|:...:| :..|:::||:.:|..|||||          |:..|..:.|.|           
  Fly   723 -AILVKRTNSG-SQIWTMEKLENKLIDMREMY----------QEHKERVLNGLD----------- 764

Mouse   890 VGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDAMEDFDDEAFVDDTGSDAGTEEGSE 954
                                                         :|.|                
  Fly   765 ---------------------------------------------EDNA---------------- 768

Mouse   955 LFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEA 1019
               ...||||:......|:|.|.::|..|.:.|.|.:...|:|::|||.|.|:|.::.||     
  Fly   769 ---KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIA----- 825

Mouse  1020 PDYGSGIRQSGTAKISFDNEYFNQSDFSSAAMTRSGLSLEELRIVEGQGQSSEVISPPEEVNRMN 1084
                                    .......|..|        :.|..|.|.:....|       
  Fly   826 ------------------------GQMPQDRMCES--------VSESSGDSRDEYDDP------- 851

Mouse  1085 DLDLKSGTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYAD-IFCQFNFLHRHDE 1148
                           ::..|.:|          |.|||:..|||:....:: :|||:.| ..|.|
  Fly   852 ---------------VDPTSNQI----------TCRVTIKCASGLPLSLSNFVFCQYTF-WGHQE 890

Mouse  1149 AFSTEPLKN-----NGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQD 1208
              ...|:.|     :.:.....|.|.|:..|.:.|.|:::.....:..||:||........:|.:
  Fly   891 --MVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWE 953

Mouse  1209 LNSPPQPSRRFFPPPMPLSKPVPATKLNTMNKTTLGQSMSKYDLLVWFEISELEPTGEYIPAVVD 1273
            :......:|........||:.:.                      :|.||.||...|||.|..|.
  Fly   954 VEQQQAKARSLVDRWAELSRKIE----------------------LWVEIHELNDNGEYSPVEVT 996

Mouse  1274 HTAGLPCQGTFLLHQGIQRRITV------------------------------------------ 1296
            :...:...|.:.|.||.|||:.|                                          
  Fly   997 NRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEE 1061

Mouse  1297 --TIIHEKGSELHWK-------DVRELVVGRIRNKPEVDE-----------------AAVDA--- 1332
              |::.||.||...:       .::.|:....:|:.|.:.                 ..|.|   
  Fly  1062 DLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGS 1126

Mouse  1333 --------------------VLSLNI----ISAKS----LKAAHSSS-------RTFYRFE---- 1358
                                ||.||:    :||::    |..|..:|       ..||..:    
  Fly  1127 GIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQH 1191

Mouse  1359 --------AVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPA----VITKDVCM----- 1406
                    |.||||:|:|..|||||...|::|:.|...:.|.|   ||    |:.|.:.:     
  Fly  1192 LDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSH---PAPMDLVLRKRLSINIKKG 1253

Mouse  1407 -VFYSRDAKISPPRSLRNLFGSGYSKSPDSNRVTGIYEL----SLCKMADTGSPGMQRRRRKVLD 1466
             ....|..|....|....::.||.:....||......||    ||.::|.:|.           |
  Fly  1254 QTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGD-----------D 1307

Mouse  1467 TSVA--------YVRG----EENLAGWRPRGDSLILE----HQWELE------------------ 1497
            .|.:        |.||    |..|...|.|.:..:.|    |...|.                  
  Fly  1308 CSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDA 1372

Mouse  1498 KLELLHEVEKTRHFL-LLRERLGDSVP---------------------KSLSDSLSPSLSSGTLS 1540
            .:|.|..|.::..|. |....||:...                     |..||. ||..:.|..|
  Fly  1373 SMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDD-SPGKAFGIAS 1436

Mouse  1541 TSTS-ISSQISTTTFESAI--------TPSES---SGYDSADVESLVDREKELATKCLQLLTHTF 1593
            .:|| :.....||..|..:        .|.:|   |.| :|:.|....:.|.:||:.....:.|.
  Fly  1437 PATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEY-AAEYEQERQQNKSMATRSRLTASKTM 1500

Mouse  1594 NREFSQVHGSISDCKLSDISPIGRD----PSVSSFSSSTLTPSS------TCPSL-----VDSRS 1643
            : .|..|....:...||..|....:    ..:::.|.|:.|.|.      :|.:|     ...||
  Fly  1501 D-SFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRS 1564

Mouse  1644 SSMDQKTPEANSRASSPCQEFEQFQIVPTVETPYLARAGKNEFLNLVPDIEEVRAGSVVSKKGYL 1708
            .|:|: ||:.: |.:|              .:|...:|..|.||..:|..:........:||...
  Fly  1565 MSIDE-TPDFD-RVNS--------------NSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQE 1613

Mouse  1709 HFKEPL 1714
            .|..||
  Fly  1614 AFTHPL 1619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kif1bNP_001277924.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 221/361 (61%)
KISc 5..361 CDD:214526 221/360 (61%)
Interaction with KBP. /evidence=ECO:0000250 270..350 54/79 (68%)
Kinesin_assoc 358..555 CDD:292801 56/196 (29%)
FHA 532..636 CDD:238017 38/103 (37%)
Prefoldin 662..717 CDD:298833 15/70 (21%)
KIF1B 845..892 CDD:289208 11/46 (24%)
DUF3694 1313..1413 CDD:289256 38/176 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1522..1571 17/81 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1620..1659 13/49 (27%)
PH_KIFIA_KIFIB 1701..1799 CDD:269939 5/14 (36%)
PH 1702..1795 CDD:278594 5/13 (38%)
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 221/361 (61%)
KISc 6..359 CDD:214526 221/359 (62%)
Kinesin_assoc 356..468 CDD:292801 54/194 (28%)
FHA 446..546 CDD:238017 38/104 (37%)
KIF1B 741..786 CDD:289208 18/129 (14%)
DUF3694 <1196..1252 CDD:289256 21/58 (36%)
CAP_GLY 1786..1850 CDD:279625
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100247
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.850

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