DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Kif1a and cmet

DIOPT Version :9

Sequence 1:XP_006529218.1 Gene:Kif1a / 16560 MGIID:108391 Length:1800 Species:Mus musculus
Sequence 2:NP_524993.3 Gene:cmet / 53561 FlyBaseID:FBgn0040232 Length:2189 Species:Drosophila melanogaster


Alignment Length:1971 Identity:403/1971 - (20%)
Similarity:719/1971 - (36%) Gaps:632/1971 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse     4 ASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINY- 67
            :|::|.::|||..              .|.|:.    .|.||.......|    ||..|...:| 
  Fly     7 SSIQVCIKVRPCE--------------PGLTSL----WQVKERRSIHLAD----SHAEPYVFDYV 49

Mouse    68 ----ASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFS 128
                ||.::|:..:.:.::....:|:|..|||||||.:||:|||||  ::...|::....:::|.
  Fly    50 FDEGASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG--DEQNPGVMVLAAKEIFQ 112

Mouse   129 RINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLS--KLAVTSYND 191
            :|:..|  ...:.:.|.|:|||.|::.||||.||: :|::.|.   |..:.:::  :..:||..|
  Fly   113 QISSET--ERDFLLRVGYIEIYNEKIYDLLNKKNQ-DLKIHES---GNGIVNVNCEECIITSEVD 171

Mouse   192 IQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHD-AETNITTEKVSKISLVDLAGSERA 255
            :..|:..|||.|||..|||||.||||||:|.||...::.| ::.:...:.|  ::||||||||||
  Fly   172 LLRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSV--LNLVDLAGSERA 234

Mouse   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLG 320
            |.|||:|.|||||.:|||||..|..||.:|:|     |.:.:     |..||||.||.:|:.:||
  Fly   235 DQTGARGARLKEGGHINKSLLFLSNVIKSLSE-----NADNR-----FTNYRDSKLTRILQASLG 289

Mouse   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNN-KLIRELKDEVTRLRDLLY 384
            ||:.|:::..:.|:.:  :|:.|||.:|.|||:||....:||..:: .:::.|:.|:..|:|.| 
  Fly   290 GNAFTSIICTIKPSIM--EESQSTLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKL- 351

Mouse   385 AQGLGDITDTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLK-- 447
                                                   |.....:|       :::.:|.|:  
  Fly   352 ---------------------------------------AEEERKNE-------NQQKVEHLERQ 370

Mouse   448 ---ETEKIIA--ELNETWEEKLRRTEAIRMEREAL-LAEMGVAMREDGGTLGVFSPKKTPHLVNL 506
               :..|||.  .|::..::|.|||.........| |||.|..  ||                .:
  Fly   371 IKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTT--ED----------------RI 417

Mouse   507 NEDPLMSEC---LLYYIKD---------------GVTRVGREDAERRQDIVLSGHFIKEEHCIFR 553
            ::.|.:|..   :.::..:               |...:|.|...      :|..|:..| ||..
  Fly   418 DQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINILGSLDIGTESNS------ISEEFLPAE-CIDF 475

Mouse   554 SDSRGGGEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPC 618
            ...|                          |.:|:....|                   |:....
  Fly   476 GSPR--------------------------PDVLKPMLTI-------------------RQLPDL 495

Mouse   619 AETPAEPVDWAFAQREL--------LEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLD 675
            ..||..|:.....::|:        |||. .:::.|..|.|:|...:...:|:.    |||:.|.
  Fly   496 PLTPKGPLTTDKIKKEIQDLQMFTSLEKH-FEVECEEVQGLKEKLAEVTAQRDN----LEQESLA 555

Mouse   676 YESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAI 740
            .:.:.:||:|::.|     :..:.|....::...|.:........|                   
  Fly   556 EKERYDALEKEVTS-----LRADNEAANSKISELEEKLSTLKQTMR------------------- 596

Mouse   741 FLKEANAISVELKKKVQFQF-------VLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEV 798
            .::..|.::|.|    :|:|       .|..|.|.|          |..::|:            
  Fly   597 IMEVENQVAVGL----EFEFEAHKKSSKLRVDDLLS----------ALLEKES------------ 635

Mouse   799 QDQKNGATHYWTLEKLRQRLD-LMREMYDRAAE--VPSSVVEDCDNVVTGGDPFYDRFPWFRLVG 860
                       |:|.|::.|| |.|::...:.|  :.|...|..|                 :.|
  Fly   636 -----------TIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQED-----------------IAG 672

Mouse   861 SSVISGCNSYPLL--------NTCMSERMAALTPSPTFSSPDSDTTEPAEEQSVGEEEEEEEEEE 917
            .|:.:.|.....|        |:|..:::.                  .|..||.::.|..|...
  Fly   673 DSICNKCEELEKLIADLESKKNSCECDQLR------------------LEIVSVRDKLESVESAF 719

Mouse   918 EEEEEEDLEDDVFPEHTLCDGQDPFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVK 982
            .....|     :..:.|.|:                    .||..|            |......
  Fly   720 NLASSE-----IIQKATDCE--------------------RLSKEL------------STSQNAF 747

Mouse   983 GFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHF-EKFQSESCPVVGMSRSGTSQEELRIV 1046
            |.|:....|:....:|       :|:|...:....:|. ||:|.             .|||...:
  Fly   748 GQLQERYDALDQQWQA-------QQAGITTLHEKHEHVQEKYQK-------------LQEEYEQL 792

Mouse  1047 EGQGQGADAGPSADEVNNNTCSAVPPEGLMDSPEKAALDGPLDTALDHLR--LGSTFTFRVTVLQ 1109
            |.:.:.|.:.......|:||         ....:.|:|:..|:.|.:.|.  ..|..|.....:|
  Fly   793 ESRARSASSAEFQRLQNDNT---------KFQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQ 848

Mouse  1110 ASSISAEYADIFCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIV 1174
            ...::|:..::...|..:.|..:..|.:.:::......|.    :.|....|....|.::|..|.
  Fly   849 NHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALR----EEIKQRPTSHVEESMRSSGIS 909

Mouse  1175 FEVFGHYQQ-----HPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTMTRPSPGPCHCKY 1234
            .: |...:|     |.|..|.:.|   .:...:|...:..|.:   |.::. :.:..||      
  Fly   910 SD-FDEQKQDINLLHQFVQLSESV---QQIELQHHSGISRLFR---ANQMK-LDQSEPG------ 960

Mouse  1235 DLLVYFEICELEANGDYIPAVVDHRGGMP----CMGTFLLHQGIQ-RRITVTLLHETGSHIRWKE 1294
                 .::| || :.:||..  |:|....    |:..||.....| :|:       :..|:...|
  Fly   961 -----LKLC-LE-SAEYIEE--DNRQSDATEPICLKGFLKRHRFQIKRL-------SQEHVDMGE 1009

Mouse  1295 VREL--VVGRIRNTPETDEALID-------------PNILSLNILSSGYVHPAQDDRQFLDS--- 1341
            .:.|  ::.::....|...||::             .|:.|..:..|..::..:|.::.::|   
  Fly  1010 EKRLLDIISQLEQEIEEKSALMEATEATINEMREQMTNLESALLEKSVIINKVEDYQRQIESLEK 1074

Mouse  1342 ---DIPRTFYQFE--AAWDSSMHNSLLLNRVTP-------------YREKIYMTLSAYI------ 1382
               ::...:.:.:  ...:|||..|||  ||.|             .||:...||...|      
  Fly  1075 QNAEMTMVYEELQDRVTRESSMSESLL--RVPPDEDTLPGCPTSPSRREQEVATLKTSITELQSQ 1137

Mouse  1383 ------EMENCTQP--------AVITKDF------CMVFYSRDAKLPA-SRSIRNLFGSGSLRAT 1426
                  |:||..:.        |.:..||      |:....|.|:|.. ::..:.|....:.:.:
  Fly  1138 VSDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAELDEDTKQKQELLDRQAQKLS 1202

Mouse  1427 EGNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQW--EL 1489
            :          .||.:..     :|::..::::   .|.:..|:|:....:.|.::|..|:  ::
  Fly  1203 D----------DLCLIDQ-----LQKKNAQLVE---QYHKATESLSLADAKPDQILLSSQYDSQI 1249

Mouse  1490 EKLSLL----------------QEVEKTRHYLLLREKLETTQRPGPEVLSPASSEDSESRSSSGA 1538
            |||:.|                .|:...|...||  ::||.::.. :....|..::::.|..|..
  Fly  1250 EKLNQLLNAAKDELHDVRRIKDDEISALRMEFLL--QIETNEKEN-QAKFYAELQETKDRYESNV 1311

Mouse  1539 S------------------------SPLSAEGQPSPLEAPNER-----QRELAVKCLR-LLMHTF 1573
            :                        ..|.:..:.:..:|..||     |.:..::.:| .|.:..
  Fly  1312 AELKEKLLQVEETLSSVTVRCQAELEALKSAHKENISQAVEERNNLIVQHQAEMETIRETLKNKL 1376

Mouse  1574 NREYTHSHVCISASESKLSEMSVTLM---------RDPSMSPLGAATLTPSSTCPSLIEGRYGAT 1629
            ....|.......|..::::|:..|||         ||...|.|...    ..|...:|.|....:
  Fly  1377 AEASTQQSKMEDAFRAEINEVRATLMEQLNQTKEDRDKGASKLEEV----KKTLEQMINGGRVMS 1437

Mouse  1630 DVRTPQPCSRPASPEPELLPELDSKKTPSPVRAT-------ETEKE----PQRLLVPDIQEIRVS 1683
            |.                :.||:..|....:...       |.||:    .::|.:..:...::|
  Fly  1438 DT----------------IAELEKTKAEQDLAVNKLTKDNIELEKQCSKTQEQLQMESLTRDQIS 1486

Mouse  1684 PIVSKKGYLHFLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQVE----YSEDQQA 1744
              ...:.::..||...|...||.:.:           ::..::.||.|...::|    .||.|:|
  Fly  1487 --FEIEAHIKKLELIVASSKKRIIEL-----------EEKCDQQVLELDKCRLEKLSLESEIQKA 1538

Mouse  1745 MLKTPNTFAVCTEHRGILLQA 1765
                 |:...||..:...|||
  Fly  1539 -----NSEHSCTMEKLQELQA 1554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kif1aXP_006529218.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 134/364 (37%)
Kinesin_assoc 358..524 CDD:374417 28/192 (15%)
FHA 501..605 CDD:238017 14/121 (12%)
DUF572 <607..>685 CDD:367968 19/85 (22%)
KIF1B 814..861 CDD:372100 9/49 (18%)
DUF3694 1250..1406 CDD:372133 42/222 (19%)
PH_KIFIA_KIFIB 1681..1783 CDD:269939 20/89 (22%)
cmetNP_524993.3 KISc 8..328 CDD:214526 134/363 (37%)
Motor_domain 8..321 CDD:277568 132/356 (37%)
Smc <680..1449 CDD:224117 156/929 (17%)
TMPIT 779..>867 CDD:285135 21/109 (19%)
Smc 1042..1910 CDD:224117 100/574 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

Return to query results.
Submit another query.