DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif1a and Kif3C

DIOPT Version :9

Sequence 1:	XP_006529218.1	Gene:	Kif1a / 16560	MGIID:	108391	Length:	1800	Species:	Mus musculus
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	219/755 - (29%)
Similarity:	330/755 - (43%)	Gaps:	192/755 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 SVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYAS 69
            ::||.||.||.|..|..|:.:.|::::....::.||.......|.|.||..|...|..|
  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTE------ 62

Mouse    70 QKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQE-KDQQGIIPQLCEDLFSRINDT 133
              .:|.::...:::...||||..||||||||.||::||.|.:. .:..||||:..:.:|.||:.|
  Fly    63 --VIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMT 125

Mouse   134 TNDNMSYSVEVSYMEIYCERVRDLLNPKNKG----NLRVREHPLLGPYVEDLSKLAVTSYNDIQD 194
            |  |:.|...|:|:|||.||:||||| ||:.    |..::|.|.:|..|..|:...|.:.|...|
  Fly   126 T--NVRYLALVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYD 187

Mouse   195 LMDSGNKARTVAATNMNETSSRSHAVFNIIFTQK------RHDAETNITTEKVSKISLVDLAGSE 253
            .:..|||.|..|||.||:.|||||.:|.|...|.      ..||...|..   .|:|||||||||
  Fly   188 WLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICR---GKLSLVDLAGSE 249

Mouse   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLREN 318
            |...|||:|.||||.:.||.||:.||.|||:|.:           .|...:|:|||.||.||:::
  Fly   250 RQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-----------GKAKHVPFRDSKLTRLLQDS 303

Mouse   319 LGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLL 383
            ||||::|.|::.:||.||:||||:||||||.|||.|.....|||||.:..:|:.::|:..|:.:|
  Fly   304 LGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML 368

Mouse   384 YAQGLGDITDTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKE 448
              |....|.:.|..|      |.::                                      |.
  Fly   369 --QESQQIINKNNDP------NKII--------------------------------------KS 387

Mouse   449 TEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGT-LGVFSPKKTPHLVNLNEDPLM 512
            ..|||...|      :..|:.::      :.::|...:....| ..:.:....|.:.:..|..|.
  Fly   388 PLKIIQHTN------MNSTKNVQ------IIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQ 440

Mouse   513 SECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVN 577
            :...:..||..:  :|   .||..|..|     ||:|.                     |..|..
  Fly   441 ARSRIDLIKRSL--IG---GERIHDFEL-----KEKHM---------------------ARKYAA 474

Mouse   578 GKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGID 642
            .:.::..:|..|                         |..|.:            |:||:.....
  Fly   475 QRHLSAIAIALS-------------------------RVKCED------------RDLLQGHYAT 502

Mouse   643 MKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQ 707
            :.||:     ::::.|.|:.:|...:||.:..|..|:.     |:|          .|:..||::
  Fly   503 ITQEI-----DIKNDYIRKCKEKIKMLEMEVSDLNSEF-----QLD----------REDYLDEIR 547

Mouse   708 WTERECELALWAFRKW---------KWYQFTSLRDLLWGN 738
            ...|:.:.....|.|:         .|...|.|::.||.:
  Fly   548 NLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWND 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif1a	XP_006529218.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	153/366 (42%)
		Kinesin_assoc	358..524	CDD:374417	27/166 (16%)
		FHA	501..605	CDD:238017	17/103 (17%)
		DUF572	<607..>685	CDD:367968	14/77 (18%)
		KIF1B	814..861	CDD:372100
		DUF3694	1250..1406	CDD:372133
		PH_KIFIA_KIFIB	1681..1783	CDD:269939
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	152/359 (42%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	149/353 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910