DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kif1a and Klp98A

DIOPT Version :9

Sequence 1:XP_006529218.1 Gene:Kif1a / 16560 MGIID:108391 Length:1800 Species:Mus musculus
Sequence 2:NP_524532.2 Gene:Klp98A / 43310 FlyBaseID:FBgn0004387 Length:1265 Species:Drosophila melanogaster


Alignment Length:1549 Identity:428/1549 - (27%)
Similarity:689/1549 - (44%) Gaps:419/1549 - (27%)


- Green bases have known domain annotations that are detailed below.


Mouse     4 ASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPK------QPKETPKSFSFDYSYWSHTSP 62
            :|:|||||||||||||:..|::.|::|....|.::.|:      ..::....|:|||||||..: 
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDA- 65

Mouse    63 EDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLF 127
            ||.::|:|:|||.|:|.:::..|:||||.|:|||||||:||::||||  ..:..|:||::||:||
  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMG--TPNNPGLIPRICEELF 128

Mouse   128 SRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGN-LRVREHPLLGPYVEDLSKLAVTSYND 191
            :|:.........|....||:|||.|||:|||..::.|: ||||||..||||||:||:.||:.:::
  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDE 193

Mouse   192 IQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERAD 256
            ||:.:..||..||.|:||||:|||||||:|.|.|.|...  ..::.:|.||||.||||||||||:
  Fly   194 IQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVF--MNDMPSETVSKIHLVDLAGSERAN 256

Mouse   257 STGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNK----------NKKKKKTDFIPYRDSVL 311
            :|||.|.||||||:|||||.|||.|||||||...|.:.          |...|:..:||||||:|
  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321

Mouse   312 TWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEV 376
            ||||:::|||||:|.|:|||||||.||.|||||||||:|||.|.....:|||.|.||||||::|:
  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386

Mouse   377 TRLRDLLYAQGLGDITDTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEE 441
            .:|:.:|    .|||                  .|...||..|:.                    
  Fly   387 NKLKSML----AGDI------------------HSLQPSLKVLAD-------------------- 409

Mouse   442 AIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNL 506
             :::.:..||:   |.|.|.||.:..::|..|:::|      .:|:.|  :||....:.|||:.:
  Fly   410 -LQKKEAQEKV---LTEEWTEKWKVAQSILQEQKSL------GLRKSG--VGVVLDSEMPHLIGI 462

Mouse   507 NEDPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHC-IFRSDSRGGGEAVVTLEPCE 570
            :.| :.:...||.:|:|.||:|.|||:..|||.|:|..|:.:|| ||   .:||   ||||.|..
  Fly   463 HND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIF---LKGG---VVTLHPWP 520

Mouse   571 GADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQREL 635
            .|..:||...:.||..:..|:.|::|::::||||:|.:|.:.|:....::.....:....:.:|.
  Fly   521 LAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSKEN 585

Mouse   636 L-------EKQGIDMKQEMEQRL----------QELEDQYRREREEATYLLEQQRLD-------Y 676
            |       ::.|....:..|::.          .||:|:.|:..:.....|:|..::       |
  Fly   586 LLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQLNVERVQMHDQY 650

Mouse   677 ESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRD-LLWGNAI 740
            ::|:..|.:::       :..|:||.:.......||.||             .:.:| |||    
  Fly   651 KTKVRKLTEEL-------IRLEQEEMDGLQLLNCREQEL-------------IARKDMLLW---- 691

Mouse   741 FLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGA 805
               |.|      .:|||...|....:.:          :...|.:.|.|.. .||.|:|:.::..
  Fly   692 ---EKN------NEKVQIDIVCRQISAF----------QTQLDSKKRDFSE-YVAKELQELQDCG 736

Mouse   806 THYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGSSVISGCNSY 870
                .|:::..:::....:.|..      :::..|::    |.|..:|     :..:|.......
  Fly   737 ----KLDEMGMKIEEGTPLNDEL------LLQVSDSL----DLFAAQF-----IKDTVRRNNEEI 782

Mouse   871 PLLNTCMSERMAALTPSPTFSSPDSDTTEPAEEQ----SVGEEEEEEEEEEEEEEEEDLE----- 926
            ..|:..::|:...|..|.|..:...:|....:.|    .:...|.|.|.:....::::::     
  Fly   783 RKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAESQAMRAKKQNMKLQLGN 847

Mouse   927 ------------DDVFPEHT--LCDGQDPFYDRPPLFSLVGRAFVY------LSNLLYPVPLVHR 971
                        |||....|  .|   |.|:......|||....:.      |||.         
  Fly   848 KSMSTSTSTNEADDVSKSDTYETC---DTFHTAQSNLSLVSSPTITEGQQSPLSNC--------- 900

Mouse   972 VAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRS 1036
                               :..|::||.|         |.|........|  .|.:|.....|.|
  Fly   901 -------------------SCDAEDEAED---------TRKDDLSGSSEE--TSRTCTAGPSSGS 935

Mouse  1037 GTSQEELRIVEGQGQGADAGPSADEV--NNNTCSAVPPEGLMDSPEKAAL-DGPLDTALDHLRLG 1098
            |:....   :.|.|......||:..:  ::..|        :||..:|.| :|.|:.....:|..
  Fly   936 GSGSVG---IGGSGSAPSCTPSSQAIMSDSGVC--------LDSRNQAILQNGHLNNYKQAVRTS 989

Mouse  1099 STFTFRVTVLQASSISAE---YADI---FCQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIA 1157
            ...|       .|..|.|   ::|:   :|..:.:.|...|.....:|              |:.
  Fly   990 DEDT-------GSCSSCELGRHSDVARPYCPLHSLRRKIAAQKALIMK--------------NLE 1033

Mouse  1158 VEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTM 1222
            .::.|:.::                :|         ::.|:..:|.:.::               
  Fly  1034 TDLNKAQLD----------------EH---------IADLQDLQRRYIQM--------------- 1058

Mouse  1223 TRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRR--ITVTLLHE 1285
                      :.::|.  .:.:|||:..   ...|.|.||.  ..:.|...|.|.  ::.|.:.|
  Fly  1059 ----------EQEMLQ--SVQDLEAHAQ---CCADERSGME--RQYELASSIMRSSVMSPTSMEE 1106

Mouse  1286 TGSHIRWKEVRELVVGRIRNTPETDEALIDPNILSLNILSSGYVHPAQDDRQFLDSDIPRTFYQF 1350
            :.|.| :..........:|..||.:..:..|:.:   :..:|                .:|.|::
  Fly  1107 STSQI-YSPSMTRSCPSMREFPEGEHFITIPSFV---MRGAG----------------KQTHYEY 1151

Mouse  1351 E---AAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVITKDFCMVFYSRDAKLPASR 1412
            |   |..|..::   :|.|.:.:||       .::.|::|             :.::.:.||..|
  Fly  1152 EVRIALPDGKLN---ILRRYSRFRE-------LHLCMKHC-------------YGAKISALPFPR 1193

Mouse  1413 SIRNLFGSGSLRATEGNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVR 1466
              |.||.|.|                        .| :.:.|||:|:   .|:|
  Fly  1194 --RELFASNS------------------------EP-VAKHRRRLLE---LYLR 1217

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kif1aXP_006529218.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 197/373 (53%)
Kinesin_assoc 358..524 CDD:374417 41/165 (25%)
FHA 501..605 CDD:238017 42/104 (40%)
DUF572 <607..>685 CDD:367968 15/101 (15%)
KIF1B 814..861 CDD:372100 5/46 (11%)
DUF3694 1250..1406 CDD:372133 27/160 (17%)
PH_KIFIA_KIFIB 1681..1783 CDD:269939
Klp98ANP_524532.2 KISc_KIF1A_KIF1B 2..371 CDD:276816 197/373 (53%)
KISc 3..371 CDD:214526 197/372 (53%)
Kinesin_assoc 370..478 CDD:292801 41/162 (25%)
FHA 456..555 CDD:238017 42/105 (40%)
PX_KIF16B_SNX23 1131..1259 CDD:132784 28/159 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0245
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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