DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif13a and Kif3C

DIOPT Version :9

Sequence 1:	XP_036013758.1	Gene:	Kif13a / 16553	MGIID:	1098264	Length:	1840	Species:	Mus musculus
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	700	Identity:	216/700 - (30%)
Similarity:	333/700 - (47%)	Gaps:	117/700 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MSDTKVKVAVRVRPMNRRELELNTKCVVEM-EGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSM 64
            ||: .:||.||.||||:.|.|.|.:.:||: |...:|.:|....::|      |.|.||..:...
  Fly     1 MSE-NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQ------KKFIFDSVYNMK 58

Mouse    65 DESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMG---HAEQLGLIPRLC 126
            .::        ||::..:...::|...:|||..||||||||.||:.:|.|   .:...|:||:..
  Fly    59 TDT--------EVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCF 115

Mouse   127 CALFQRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLK--VREHKVLGPYVDGLSQLA 189
            ..:|:||::..|  ..:...|:|:|||||::||||:...:...:.  ::|...:|..|..|:...
  Fly   116 DHIFERISMTTN--VRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQP 178

Mouse   190 VTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGN---SGEKVSKVSLV 251
            |.:.......:..|||:|..|||.||:.|||||.:|.|.:.|:.:....|:   .|....|:|||
  Fly   179 VVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLV 243

Mouse   252 DLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKNKFVPYRDSVLTWLLKDN 316
            |||||||..||||.|:||||.|.||.||:.||.|||||.|     ||.|.||:|||.||.||:|:
  Fly   244 DLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-----GKAKHVPFRDSKLTRLLQDS 303

Mouse   317 LGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQL 381
            ||||::|.||:.|||...:|:||:||||||.|||.|.|...:||||....:|:.:.|:..|:..|
  Fly   304 LGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML 368

Mouse   382 SQAEAMKAPELKEKLEESEKLIKE-LTVTWEEKLRKTEAIAQERQRQLESMG----ISLETSGIK 441
            .:::     ::..|..:..|:||. |.:.....:..|:.:      |:..:|    .|.:|:...
  Fly   369 QESQ-----QIINKNNDPNKIIKSPLKIIQHTNMNSTKNV------QIIDLGRNCKASFKTNNSI 422

Mouse   442 VGDDKCYLVNLNADPALNELLVYYLKDHTRVGADTSQDIQLFGIGIQPEHCEIDIAADGDITLTP 506
            :......|:....:..|.......|...:.:|.:...|.:|     :.:|.....||...:
  Fly   423 LTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGGERIHDFEL-----KEKHMARKYAAQRHL---- 478

Mouse   507 KENARSCVNGTLVCSTTQLWHGDRILWGNNHFFRI-------NLPKRKRRDWLKDFERETSSAEH 564
              :|.:.....:.|....|..|        |:..|       |...||.::.:|..|.|.|
  Fly   479 --SAIAIALSRVKCEDRDLLQG--------HYATITQEIDIKNDYIRKCKEKIKMLEMEVS---- 529

Mouse   565 DLDAASEASSEPDYNYEFAQM--------EVIMKTLNSNGGF-------PIVSLSAW------WS 608
            ||::..:...| ||..|...:        ::.:|..::.|.|       .|:..|.|      |.
  Fly   530 DLNSEFQLDRE-DYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWR 593

Mouse   609 SPWWSYLKI-----------LFPLLWFQTKLVHQHWERDPVQNVVQVLEK 647
            .|....:|:           :.||      ::|...:.:. ||.:.|.||
  Fly   594 IPESDLIKLPPATQKSGLHCIHPL------VIHSENQHNN-QNEIVVGEK 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif13a	XP_036013758.1	KISc_KIF1A_KIF1B	5..359	CDD:276816	151/362 (42%)
		Kinesin_assoc	356..468	CDD:406567	21/116 (18%)
		FHA	446..543	CDD:238017	15/103 (15%)
		Smc	<646..811	CDD:224117	1/1 (100%)
		KIF1B	788..832	CDD:403579
		DUF3694	<1255..1319	CDD:403614
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	149/357 (42%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	146/349 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910