Protein Alignment Kif13a and Klp98A

DIOPT Version :9

• Sequence 1: XP_036013758.1
• Gene: Kif13a / 16553
• MGIID: 1098264
• Length: 1840
• Species: Mus musculus
• Sequence 2: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 1524
• Identity: 431/1524 - (28%)
• Similarity: 645/1524 - (42%)
• Gaps: 431/1524 - (28%)

Mouse     4 TKVKVAVRVRPMNRRELELNTKCVVEMEGNQT-VLHPPPSNTKQGERKPPKVFAFDYCFWSMDES 67
            :.:||||||||.|.||::::.:.::|||..:| :|.|...:.:...|.....|.|||.:||.| :
  Fly     2 SSLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFD-A 65

Mouse    68 NTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALFQR 132
            ....:|.||.|:..||..:::.|::|||||:||||||||||:|:|||.....|||||:|..||.|
  Fly    66 EDPHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGTPNNPGLIPRICEELFAR 130

Mouse   133 IALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFEDIE 197
            :.:.|.....::...||:|||||:|:|||..:.:...|:||||:.|||||:.|||.||:.|::|:
  Fly   131 MRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEIQ 195

Mouse   198 SLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLY--DLQSGNSGEKVSKVSLVDLAGSERVS 260
            ..::.||..||.|:||||:.||||||:|.|...|.::  |:.|    |.|||:.|||||||||.:
  Fly   196 ECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPS----ETVSKIHLVDLAGSERAN 256

Mouse   261 KTGAAGERLKEGSNINKSLTTLGLVISSLADQAAG-------------KGKNK---FVPYRDSVL 309
            .|||.|:|||||::|||||.|||.|||:||:|..|             .|.:|   ::|||||:|
  Fly   257 ATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSIL 321

Mouse   310 TWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEV 374
            ||||||:|||||:|.|||.:|||..||.|||||||||:|||.|:|...||||.|.|:|||||||:
  Fly   322 TWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEI 386

Mouse   375 EKLREQLSQAEAMKAPELK-----EKLEESEKLIKELTVTWEEKLRKTEAIAQERQRQLESMGIS 434
            .||:..|:.......|.||     :|.|..||:   ||..|.||.:..::|.||:    :|:|:.
  Fly   387 NKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKV---LTEEWTEKWKVAQSILQEQ----KSLGLR 444

Mouse   435 LETSGIKVGDDKCYLVNLNADPALNELLVYYLKD-HTRVG---ADTSQDIQLFGIGIQPEHCEID 495
            ....|:.:..:..:|:.::.| ....:.:|.||: .||:|   ||.:|||:|.|.||:.:||.|.
  Fly   445 KSGVGVVLDSEMPHLIGIHND-VTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIF 508

Mouse   496 IAADGDITLTPKENARSCVNGTLVCSTTQLWHGDRILWGNNHFFRINLPKR--KRRDWLKDFERE 558
            :.. |.:||.|...|:..||..|:....|:..||.||.|..:.||.|.|..  |.|   ||..|.
  Fly   509 LKG-GVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLR---KDLSRS 569

Mouse   559 ----------TSSAEH--------DLDAASE--------------ASSEPDYNYE----FAQMEV 587
                      |||.|:        |.|.||.              :..:|:...|    ...:|.
  Fly   570 QLDMSRLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIEN 634

Mouse   588 IMKTLNSNGGFPIVSLSAWWSSPWWSYLKILFPLLWFQTKLVHQHWE---RDPVQNVVQVLEKQY 649
            .:|.||                              .:...:|..::   |...:.::: ||::.
  Fly   635 ALKQLN------------------------------VERVQMHDQYKTKVRKLTEELIR-LEQEE 668

Mouse   650 LE--------EKRTALEEQRLMYERELEQLR-----QQLSP-ERQPPSSASDRLAYSSQTAQQ-- 698
            ::        |:.....:..|::|:..|:::     :|:|. :.|..|...|...|.::..|:
  Fly   669 MDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCRQISAFQTQLDSKKRDFSEYVAKELQELQ 733

Mouse   699 ----------KVTQWAEERDELFRQ---SLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQ 750
                      |:.:.....|||..|   ||.....|.:|  ..||..|   ||:.|| |.|:..:
  Fly   734 DCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIK--DTVRRNN---EEIRKL-DEQIAEK 792

Mouse   751 IPAANLSANRKRGAIVSEPAIQARRKGKGTQVWTIEKLENKLIDMRDLYQEWKENVPEAKRLYGK 815
            ....|.|..:                        |.|::..:::::          .:.:||..:
  Fly   793 ERILNASTTK------------------------IAKVDETMLEIQ----------AQLERLRLE 823

Mouse   816 RGDPFYEAQ----ENHNLIGVANVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVTRITGTIPE 876
            |.:...|:|    :..|:               |||.....:|                |.|
  Fly   824 RAESEAESQAMRAKKQNM---------------KLQLGNKSMS----------------TST--- 854

Mouse   877 RMAEDDSSENSSESGSLEVVDSSGEVIHRVK---KLTCRVIIKEATGLPISLSNFVFCQYTFWDQ 938
               ..:.:::.|:|.:.|..|:    .|..:   .|.....|.|....|  |||   |.....|:
  Fly   855 ---STNEADDVSKSDTYETCDT----FHTAQSNLSLVSSPTITEGQQSP--LSN---CSCDAEDE 907

Mouse   939 CESTVAAPVVDPDVPSPQSKDAQYTVTFSHCKDYVVTVTEEFLEFISDGALAIEVWGHRCAGNGS 1003
            .|.|      ..|..|..|::...|.|...                |.|           :|:||
  Fly   908 AEDT------RKDDLSGSSEETSRTCTAGP----------------SSG-----------SGSGS 939

Mouse  1004 PIWEVDSLHAKTRTLHDRWNEVTRRIEVWISILELNELGDYAAVELHQAKDVNTGGVFQLRQGHS 1068
                                                               |..||
  Fly   940 ---------------------------------------------------VGIGG--------- 944

Mouse  1069 RRVQVTVKPVQHSGTLPLMV---EAILSVSIGCVTARSTK-LQRG-LDSYQR----DEEDGGDMD 1124
                        ||:.|...   :||:|.|..|:.:|:.. ||.| |::|::    .:||.|...
  Fly   945 ------------SGSAPSCTPSSQAIMSDSGVCLDSRNQAILQNGHLNNYKQAVRTSDEDTGSCS 997

Mouse  1125 SYQEEDLNCVRERWSDALIKRREY--LDEQIKKVSNKK----EKTEDDMEREARLVEQWVGLTEE 1183
            |       |...|.||.   .|.|  |....:|::.:|    :..|.|:.: |:|.|....|.:.
  Fly   998 S-------CELGRHSDV---ARPYCPLHSLRRKIAAQKALIMKNLETDLNK-AQLDEHIADLQDL 1051

Mouse  1184 RNAVLVPAPGSGIPGAPADWVPPPGMETHIPVLFLDLNADDLSANEQLVGPHASGVNSILPKEHG 1248
            :...:                   .||..     :..:..||.|:.|......||:..  ..|..
  Fly  1052 QRRYI-------------------QMEQE-----MLQSVQDLEAHAQCCADERSGMER--QYELA 1090

Mouse  1249 SQFFYLPIIKHSDDEVSATASWDSSVHDSLHLNRVTPQNERIYLIVKTTVQLSHPAAMELVLRKR 1313
            |......::..:..|.|.:..:..|:..|....|..|:.|. ::.:.:.|..............|
  Fly  1091 SSIMRSSVMSPTSMEESTSQIYSPSMTRSCPSMREFPEGEH-FITIPSFVMRGAGKQTHYEYEVR 1154

Mouse  1314 IA-----ANIYNKQSFTQSLKRRISLINICYSCGVTYEIVSNIPKATEEIEDRETLALLAARSEN 1373
            ||     .||..:.|..:.|.   ..:..||...     :|.:|....|        |.|:.||.
  Fly  1155 IALPDGKLNILRRYSRFRELH---LCMKHCYGAK-----ISALPFPRRE--------LFASNSEP 1203

Mouse  1374 EGTLDGETYIEKYTRGVLQVENILSLERL 1402
                     :.|:.|.:|:    |.|.||
  Fly  1204 ---------VAKHRRRLLE----LYLRRL 1219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif13a	XP_036013758.1	KISc_KIF1A_KIF1B	5..359	CDD:276816	188/372 (51%)
		Kinesin_assoc	356..468	CDD:406567	38/116 (33%)
		FHA	446..543	CDD:238017	36/100 (36%)
		Smc	<646..811	CDD:224117	34/193 (18%)
		KIF1B	788..832	CDD:403579	6/47 (13%)
		DUF3694	<1255..1319	CDD:403614	12/68 (18%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	188/373 (50%)
		KISc	3..371	CDD:214526	188/372 (51%)
		Kinesin_assoc	370..478	CDD:292801	39/115 (34%)
		FHA	456..555	CDD:238017	36/100 (36%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784	24/119 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920