DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif13a and Khc-73

DIOPT Version :9

Sequence 1:	XP_036013758.1	Gene:	Kif13a / 16553	MGIID:	1098264	Length:	1840	Species:	Mus musculus
Sequence 2:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster

Alignment Length:	1846	Identity:	917/1846 - (49%)
Similarity:	1156/1846 - (62%)	Gaps:	233/1846 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMD 65
            |:..|:||||||||.||||:||:|||:||||..||:|..||...|. |||.||.||||:||:|::
  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKI-ERKQPKTFAFDHCFYSLN 64

Mouse    66 ESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALF 130
            ..: ..:|.||.||.|:|.|||:.||||||||||||||||||||::|||..|..|:|||||..||
  Fly    65 PED-ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLF 128

Mouse   131 QRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFED 195
            ..||.:......:||||||||||||||.||||||.::||||||||.|:||||||||||||||::|
  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193

Mouse   196 IESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVS 260
            |::||:||||||||||||||.|||||||||::::||.|.|..:|.||||||::||||||||||..
  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAV 258

Mouse   261 KTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGK--GKNKFVPYRDSVLTWLLKDNLGGNSQT 323
            ||||.|:||||||||||||||||||||.||||:.||  |.:||||||||||||||||||||||:|
  Fly   259 KTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRT 323

Mouse   324 SMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAEAMK 388
            .|:|||||:||||||||||||||||||||||||||||||||::|||||.|||.||..|..|....
  Fly   324 VMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSP 388

Mouse   389 APELKEKLEESEKLIKELTVTWEEKLRKTEAIAQERQRQLESMGISLETSGIKVGDDKCYLVNLN 453
            ..::::||.|||.|:|:::.||||||.|||.|..|||:.||.||||::.|||||..:|.||||||
  Fly   389 VGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLN 453

Mouse   454 ADPALNELLVYYLKDHTRVGADT----SQDIQLFGIGIQPEHCEIDIAADGDITLTPKENARSCV 514
            |||:|||||||||||.|.:|..|    ..||||.|:|||||||.|.| .|..:.:.|.:.||..|
  Fly   454 ADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITI-EDSGLYMEPVQGARCFV 517

Mouse   515 NGTLVCSTTQLWHGDRILWGNNHFFRINLPKRKRRDWLKDFERETSSAEHDLDAASEASSEP--- 576
            ||:.....|.|.:||||||||:||||:|.||...                    .|..:|||
  Fly   518 NGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNN--------------------TSMCASEPQTP 562

Mouse   577 ----DYNYEFAQMEVIMKTLNSNGGFPIVSLSAWWSSPWWSYLKILFPLLWFQTKLVHQHWERDP 637
                |||  ||:.|::...|::                                         ||
  Fly   563 AQLIDYN--FARDEIMQNELSN-----------------------------------------DP 584

Mouse   638 VQNVVQVLEKQYLEEKRTALEEQRLMYERELEQLRQQLSPER-QPPSSASD-----RLAYSSQTA 696
            :|..:..||:|:.|:|:.|||:||..|||:.:|||..|||.. ..|.:..|     ::..::.|:
  Fly   585 IQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTS 649

Mouse   697 QQKVTQWAEERDELFRQSLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQIPAANLSANRK 761
            |.:|.:||:||||:||:||.:|:..:::||:||:|||||||||.|.|.:.||||||.||||.||:
  Fly   650 QMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRR 714

Mouse   762 RGAIVSEPAIQARRKGKGTQVWTIEKLENKLIDMRDLYQEWKENVPEAKRLYG------KRGDPF 820
            |||.||||||..:|...|:|:||:|||||||||||::|||.||.|     |.|      |..|||
  Fly   715 RGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERV-----LNGLDEDNAKPQDPF 774

Mouse   821 YEAQENHNLIGVANVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVTRITGTIP-ERMAEDDSS 884
            ||:|||||||||||:|||.||.||||.|..|||||||||||||.||:.||.|.:| :||.| ..|
  Fly   775 YESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCE-SVS 838

Mouse   885 ENSSESGSL--EVVDSSGEVIHRVKKLTCRVIIKEATGLPISLSNFVFCQYTFWDQCESTVAAPV 947
            |:|.:|...  :.||.:.      .::||||.||.|:|||:|||||||||||||...|..|  ||
  Fly   839 ESSGDSRDEYDDPVDPTS------NQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVV--PV 895

Mouse   948 VDPDVPSPQSKDAQYTVTFSHCKDYVVTVTEEFLEFISDGALAIEVWGHRCAG-NGSPIWEVDSL 1011
            ::.:   ..:.|......|.|.:|:.||:.|||||...:|||:|||||||.|| :.:..|||:..
  Fly   896 INAE---STAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQ 957

Mouse  1012 HAKTRTLHDRWNEVTRRIEVWISILELNELGDYAAVELHQAKDVNTGGVFQLRQGHSRRVQVTVK 1076
            .||.|:|.|||.|::|:||:|:.|.|||:.|:|:.||:....:|.|||::|||||..|||.|.||
  Fly   958 QAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVK 1022

Mouse  1077 PVQHSGTLPLMVEAILSVSIGCVTARSTKLQRGLDSYQRDEEDGGDMDSYQEEDLNCVRERWSDA 1141
            |||:|||||::.::|::|:||.||.|| :|||.|             ||||||||..:||:||:|
  Fly  1023 PVQNSGTLPIICQSIVNVAIGSVTVRS-RLQRPL-------------DSYQEEDLTVLREKWSEA 1073

Mouse  1142 LIKRREYLDEQIKKVSNKKEKTEDDMEREARLVEQWVGLTEERNAVLVPAPGSGIPGAPADWVPP 1206
            |.:||:|||:||:.:..|:||.|.:.|||..||.|||.||||||||||||||||||||||.|.||
  Fly  1074 LGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPP 1138

Mouse  1207 PGMETHIPVLFLDLNADDLSA---NEQLVGPHASGVNSILPKEHGSQFFYLPIIKHSDDEVSATA 1268
            .|||.|:|||||:||.|||||   |::|   ..:|:||||.||||.:|:.|.|::|.|.:|...|
  Fly  1139 SGMEPHVPVLFLNLNGDDLSAQNTNDEL---SVAGINSILSKEHGHKFYTLQILQHLDKDVCCVA 1200

Mouse  1269 SWDSSVHDSLHLNRVTPQNERIYLIVKTTVQLSHPAAMELVLRKRIAANIYNKQSFTQSLK--RR 1331
            |||||:|||..|||||..|||:|||::|||:|||||.|:||||||::.||...|:.|..||  |.
  Fly  1201 SWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRL 1265

Mouse  1332 ISLINICYSCGVTYEIVSNIPKATEEIEDRETLALLAARSENEGTLDGETYIEKYTRGVLQVENI 1396
            :...|..:..|||||:|||||||:||:||||:||.|||..::....|||||||||||||..||:|
  Fly  1266 VRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETYIEKYTRGVSAVESI 1330

Mouse  1397 LSLERLRQAVTVKEALSTKAR--HIRRSLSTPNVHNVSSSRPDLSGFDEDDKGWPENQLDVSDYS 1459
            |:|:||||.|.|||..:...:  .:|:::|.||...:..       ||..    .|:.|:|. .|
  Fly  1331 LTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMR-------FDAS----MESLLNVG-RS 1383

Mouse  1460 SSYQDV--ACYG---TLPRDSP---------RRSKEGCPSENPHALTVSPFKAFSPQPPKFFKPL 1510
            .|:.|:  :..|   |....||         |.|..|..|.:.     ||.|||....|...|.|
  Fly  1384 ESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDD-----SPGKAFGIASPATSKLL 1443

Mouse  1511 MPVKEEHKKRLALEARPLLSQESMPPSQAHNPGCIVTPGSNGSSMPVEHSSKPEKKIDSEEEENE 1575
                  ..:...|...||....|:                  ...|.:..|..|...:.|:|..:
  Fly  1444 ------GMRMTTLHEEPLGGHRSL------------------DEEPEDSYSDSEYAAEYEQERQQ 1484

Mouse  1576 LEALSRKLMLTQPYVPVEFADFSVYNASLENREWSSSKADLTDSRALEKAVSRSPTTSSLTSGYF 1640
            .::::.:..||.......|.|.|.::........||:.|::.....| ..:|.|.:||   |||.
  Fly  1485 NKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGL-ATLSMSSSTS---SGYG 1545

Mouse  1641 SH--SASNATLSDMAVPSSDSSDQLAVSTKEVECAEPP------GPSLAPDVRPASNQELTE--- 1694
            |.  |.:|.:..|:|...|.|.|: ......|....||      .|.| .|:..|..||..|
  Fly  1546 SQAVSCNNLSNEDIASMRSMSIDE-TPDFDRVNSNSPPNRQARVNPFL-KDMPKAKIQEQPEQQA 1608

Mouse  1695 -----------------VGRGSGKDETIAVPLEENSAL-----PKGTPSPQSIPEESSRMPCRTA 1737
                             ....|..||...:|...|:.|     ||...|...:.|..|:...:|.
  Fly  1609 KKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTE 1673

Mouse  1738 SCSELDVG-PSKD--GHQAREFCPGE 1760
            ..::...| .|.|  .|.:.:...|:
  Fly  1674 FATDNQNGNRSSDELSHSSEDLLEGD 1699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif13a	XP_036013758.1	KISc_KIF1A_KIF1B	5..359	CDD:276816	261/355 (74%)
		Kinesin_assoc	356..468	CDD:406567	71/111 (64%)
		FHA	446..543	CDD:238017	59/100 (59%)
		Smc	<646..811	CDD:224117	92/170 (54%)
		KIF1B	788..832	CDD:403579	30/49 (61%)
		DUF3694	<1255..1319	CDD:403614	40/63 (63%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	261/356 (73%)
		KISc	6..359	CDD:214526	260/354 (73%)
		Kinesin_assoc	356..468	CDD:292801	71/111 (64%)
		FHA	446..546	CDD:238017	59/100 (59%)
		KIF1B	741..786	CDD:289208	30/49 (61%)
		DUF3694	<1196..1252	CDD:289256	38/55 (69%)
		CAP_GLY	1786..1850	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	492	1.000	Domainoid score	I365
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1550	1.000	Inparanoid score	I96
Isobase	1	0.950	-	0	Normalized mean entropy	S2420
OMA	1	1.010	-	-		QHG48008
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	1	1.000	-	-		FOG0002517
OrthoInspector	1	1.000	-	-		otm44296
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	1	1.000	-	-		X1652
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820