Protein Alignment Kif11 and Klp61F

DIOPT Version :10

• Sequence 1: NP_034745.1
• Gene: Kif11 / 16551
• MGIID: 1098231
• Length: 1052
• Species: Mus musculus
• Sequence 2: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Alignment Length: 1115
• Identity: 384/1115 - (34%)
• Similarity: 605/1115 - (54%)
• Gaps: 143/1115 - (12%)

Mouse     6 SSLKKKEEKGRNIQVVVRCRPFNLAERKANAHSVVECDHARKEVSVRTAGLTDKTSKKTYTFDMV 70
            :|.:.:::..:||||.||.||.|..||...:..||:....|:.|:..|  |..|.:|| :|||..
  Fly     8 TSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHT--LDSKLTKK-FTFDRS 69

Mouse    71 FGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEEDPLAGII 135
            ||..:||.|||..||.|:::||:.|||||:|||||||||||.||.|..:.....:||:|...|||
  Fly    70 FGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGII 134

Mouse   136 PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVIIKGLEE 200
            ||.|..:|::|.....|:::::|.||:|||||.|||  |:|.:.::::|||...|..|||:||||
  Fly   135 PRALSHLFDELRMMEVEYTMRISYLELYNEELCDLL--STDDTTKIRIFDDSTKKGSVIIQGLEE 197

Mouse   201 ITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDL 265
            |.||:||:||::||||..:|.||.|||||.|||||:|||:.:|::|..|:||:::||||||||||
  Fly   198 IPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDL 262

Mouse   266 AGSENIGRSGAVDK--RAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRTR 328
            |||||:.::|. :|  |.||..|||||||||||||||||:|.||:|||||||||:||:||||||:
  Fly   263 AGSENVSKAGN-EKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRTK 326

Mouse   329 TSIIATISPASFNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAARE 393
            |||||||||...::||||||||||||||||.||||||||||||.::|||||||::|||||.|||:
  Fly   327 TSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARD 391

Mouse   394 KNGVYISEESFRAMNGKVTVQ-EEQIVELVEK---IAVLEEELSKATELFMDSKNELDQCKSDLQ 454
            |||:|::||::    |::|:: |.|..||.||   :..|::||....::|       .:....|.
  Fly   392 KNGIYLAEETY----GEITLKLESQNRELNEKMLLLKALKDELQNKEKIF-------SEVSMSLV 445

Mouse   455 TKTQELETTQKHLQETKLQLV---------------KEEYVSSALERTEKTLHDTASKLLNTVKE 504
            .|||||:.|:::|..||..|:               |:|.|:|.: :||:.|...|.::|.....
  Fly   446 EKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHM-KTEQVLTTQAQEILAAADL 509

Mouse   505 TTRAVSGLHSKLDRKRAIDEHNAEAQESFGKNLNSLFNNME------ELIKDGSAKQKAMLD--- 560
            .|.....||..::|:|.:||....:.:.|...:.   :|:|      .|.:|..|..|..|.
  Fly   510 ATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQ---DNLEMIGGSLNLYQDQQAALKEQLSQEM 571

Mouse   561 -----VHKTLFGNLMSSSVSALDTITTTALESLVSIPENVSARVSQISDMILEEQSLAAQSKSVL 620
                 |.:.|..| .|.|:..|..:...:|:...::...:...|.:|||.         .|::.:
  Fly   572 VNSSYVSQRLALN-SSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQ---------HSQAFV 626

Mouse   621 QGLIDELVTDLFTSLKTIVAPSVVSILNINKQLQHIFRASSTVAEKVEDQKREIDS----FLSIL 681
            ..|::::....               |.::|::|...:   .:.|..:..|..:||    |.:|:
  Fly   627 AKLMEQMQQQQ---------------LLMSKEIQTNLQ---VIEENNQRHKAMLDSMQEKFATII 673

Mouse   682 CNNLHELRENTVSSLVESQKLCGDLT----EDLKTIKETHSQE--LCQLSSSWAERFCALEKKYE 740
            .::|..:.|:......:.::| |.::    |:|:.::|..:.|  |.|...:..|......::.:
  Fly   674 DSSLQSVEEHAKQMHKKLEQL-GAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIK 737

Mouse   741 NIQKP--------LNSIQENTELRS---TDIINKTTVHSKKILAESDGLLQELRHFNQEGTQLVE 794
            |::..        ||.::|:...|:   .||.:....:.|..:..|.....||....:.|...::
  Fly   738 NLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLD 802

Mouse   795 ESVGHCSSLNSNLETVSQ----EITQKCGTLNTSTVHFSDQWASCLSKRKEELENLMEFVNGCCK 855
            :.|.:||.|..:::.::|    |..:..|::.   ||.:.....| .:.|::||.:.|
  Fly   803 QGVANCSMLQVHMKNLNQKYEKETNENVGSVR---VHHNQVEIIC-QESKQQLEAVQE------- 856

Mouse   856 ASSSEITKKVREQSAAVANQHSSFVAQMTSDEESCKAGSLELDKTIKTGLTKLN-C------FLK 913
            .:...:.:.|..:...:......|:...|...:..:..:.:..:..:....:|. |      |.:
  Fly   857 KTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQ 921

Mouse   914 QDLKLDIPTGMTPERKKYLYPTTLVRTEPREQLLDQLQKKQPPMMLNSSEASKETSQ-DMDEERE 977
            .:||...|||.||.::.::||.|||.|.|.::::.:.:::.....|:::....|.|: :.|....
  Fly   922 SELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMH 986

Mouse   978 ALEQCTE-ELVSPETTEHPSADCSSSRGLPFFQRKKPHG--KDKENRGLNPVEKYKVEEASDLSI 1039
            ::::.:| |.:...|...|....:..||.         |  ::..:..|.|......:.:|  |:
  Fly   987 SVQELSETETIMNSTPIEPVDGVTVKRGC---------GTTRNSNSNALKPPVATGGKRSS--SL 1040

Mouse  1040 SKSRLPLHTS 1049
            |:|..|..||
  Fly  1041 SRSLTPSKTS 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif11	NP_034745.1	KISc_BimC_Eg5	15..367	CDD:276815	210/353 (59%)
		PRK12704	349..>508	CDD:237177	76/177 (43%)
		CCDC158	415..>863	CDD:464943	104/504 (21%)
		Microtub_bind	915..1047	CDD:464048	32/135 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1026		12/79 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1052		7/17 (41%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	210/353 (59%)
		SMC_prok_B	<408..728	CDD:274008	77/359 (21%)
		SMC_prok_B	<651..>921	CDD:274008	49/281 (17%)
		Microtub_bind	923..>1004	CDD:464048	21/80 (26%)