DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif11 and Klp61F

DIOPT Version :9

Sequence 1:	NP_034745.1	Gene:	Kif11 / 16551	MGIID:	1098231	Length:	1052	Species:	Mus musculus
Sequence 2:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster

Alignment Length:	1115	Identity:	384/1115 - (34%)
Similarity:	605/1115 - (54%)	Gaps:	143/1115 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 SSLKKKEEKGRNIQVVVRCRPFNLAERKANAHSVVECDHARKEVSVRTAGLTDKTSKKTYTFDMV 70
            :|.:.:::..:||||.||.||.|..||...:..||:....|:.|:..|  |..|.:|| :|||..
  Fly     8 TSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHT--LDSKLTKK-FTFDRS 69

Mouse    71 FGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEEDPLAGII 135
            ||..:||.|||..||.|:::||:.|||||:|||||||||||.||.|..:.....:||:|...|||
  Fly    70 FGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGII 134

Mouse   136 PRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLSPSSDVSERLQMFDDPRNKRGVIIKGLEE 200
            ||.|..:|::|.....|:::::|.||:|||||.|||  |:|.:.::::|||...|..|||:||||
  Fly   135 PRALSHLFDELRMMEVEYTMRISYLELYNEELCDLL--STDDTTKIRIFDDSTKKGSVIIQGLEE 197

Mouse   201 ITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDL 265
            |.||:||:||::||||..:|.||.|||||.|||||:|||:.:|::|..|:||:::||||||||||
  Fly   198 IPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDL 262

Mouse   266 AGSENIGRSGAVDK--RAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTRILQDSLGGRTR 328
            |||||:.::|. :|  |.||..|||||||||||||||||:|.||:|||||||||:||:||||||:
  Fly   263 AGSENVSKAGN-EKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRTK 326

Mouse   329 TSIIATISPASFNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIERLKRDLAAARE 393
            |||||||||...::||||||||||||||||.||||||||||||.::|||||||::|||||.|||:
  Fly   327 TSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARD 391

Mouse   394 KNGVYISEESFRAMNGKVTVQ-EEQIVELVEK---IAVLEEELSKATELFMDSKNELDQCKSDLQ 454
            |||:|::||::    |::|:: |.|..||.||   :..|::||....::|       .:....|.
  Fly   392 KNGIYLAEETY----GEITLKLESQNRELNEKMLLLKALKDELQNKEKIF-------SEVSMSLV 445

Mouse   455 TKTQELETTQKHLQETKLQLV---------------KEEYVSSALERTEKTLHDTASKLLNTVKE 504
            .|||||:.|:::|..||..|:               |:|.|:|.: :||:.|...|.::|.....
  Fly   446 EKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHM-KTEQVLTTQAQEILAAADL 509

Mouse   505 TTRAVSGLHSKLDRKRAIDEHNAEAQESFGKNLNSLFNNME------ELIKDGSAKQKAMLD--- 560
            .|.....||..::|:|.:||....:.:.|...:.   :|:|      .|.:|..|..|..|.
  Fly   510 ATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQ---DNLEMIGGSLNLYQDQQAALKEQLSQEM 571

Mouse   561 -----VHKTLFGNLMSSSVSALDTITTTALESLVSIPENVSARVSQISDMILEEQSLAAQSKSVL 620
                 |.:.|..| .|.|:..|..:...:|:...::...:...|.:|||.         .|::.:
  Fly   572 VNSSYVSQRLALN-SSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQ---------HSQAFV 626

Mouse   621 QGLIDELVTDLFTSLKTIVAPSVVSILNINKQLQHIFRASSTVAEKVEDQKREIDS----FLSIL 681
            ..|::::....               |.::|::|...:   .:.|..:..|..:||    |.:|:
  Fly   627 AKLMEQMQQQQ---------------LLMSKEIQTNLQ---VIEENNQRHKAMLDSMQEKFATII 673

Mouse   682 CNNLHELRENTVSSLVESQKLCGDLT----EDLKTIKETHSQE--LCQLSSSWAERFCALEKKYE 740
            .::|..:.|:......:.::| |.::    |:|:.::|..:.|  |.|...:..|......::.:
  Fly   674 DSSLQSVEEHAKQMHKKLEQL-GAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIK 737

Mouse   741 NIQKP--------LNSIQENTELRS---TDIINKTTVHSKKILAESDGLLQELRHFNQEGTQLVE 794
            |::..        ||.::|:...|:   .||.:....:.|..:..|.....||....:.|...::
  Fly   738 NLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLD 802

Mouse   795 ESVGHCSSLNSNLETVSQ----EITQKCGTLNTSTVHFSDQWASCLSKRKEELENLMEFVNGCCK 855
            :.|.:||.|..:::.::|    |..:..|::.   ||.:.....| .:.|::||.:.|
  Fly   803 QGVANCSMLQVHMKNLNQKYEKETNENVGSVR---VHHNQVEIIC-QESKQQLEAVQE------- 856

Mouse   856 ASSSEITKKVREQSAAVANQHSSFVAQMTSDEESCKAGSLELDKTIKTGLTKLN-C------FLK 913
            .:...:.:.|..:...:......|:...|...:..:..:.:..:..:....:|. |      |.:
  Fly   857 KTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQ 921

Mouse   914 QDLKLDIPTGMTPERKKYLYPTTLVRTEPREQLLDQLQKKQPPMMLNSSEASKETSQ-DMDEERE 977
            .:||...|||.||.::.::||.|||.|.|.::::.:.:::.....|:::....|.|: :.|....
  Fly   922 SELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMH 986

Mouse   978 ALEQCTE-ELVSPETTEHPSADCSSSRGLPFFQRKKPHG--KDKENRGLNPVEKYKVEEASDLSI 1039
            ::::.:| |.:...|...|....:..||.         |  ::..:..|.|......:.:|  |:
  Fly   987 SVQELSETETIMNSTPIEPVDGVTVKRGC---------GTTRNSNSNALKPPVATGGKRSS--SL 1040

Mouse  1040 SKSRLPLHTS 1049
            |:|..|..||
  Fly  1041 SRSLTPSKTS 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif11	NP_034745.1	KISc_BimC_Eg5	15..367	CDD:276815	210/353 (59%)
		KISc	17..365	CDD:214526	208/349 (60%)
		Microtub_bind	915..1047	CDD:290642	32/135 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	950..1026		12/79 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1052		7/17 (41%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	210/353 (59%)
		Kinesin	25..356	CDD:278646	197/336 (59%)
		Microtub_bind	923..>1009	CDD:290642	22/85 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848787
Domainoid	1	1.000	376	1.000	Domainoid score	I864
eggNOG	1	0.900	-	-		E2759_KOG0243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3322
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1174
Isobase	1	0.950	-	0	Normalized mean entropy	S2292
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002556
OrthoInspector	1	1.000	-	-		oto95024
orthoMCL	1	0.900	-	-		OOG6_102884
Panther	1	1.100	-	-	LDO	PTHR47970
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	1	1.000	-	-		X1681
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.730