Protein Alignment DDX5 and bel

DIOPT Version :10

• Sequence 1: NP_004387.1
• Gene: DDX5 / 1655
• HGNCID: 2746
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_001262379.1
• Gene: bel / 45826
• FlyBaseID: FBgn0263231
• Length: 801
• Species: Drosophila melanogaster
• Alignment Length: 630
• Identity: 218/630 - (34%)
• Similarity: 323/630 - (51%)
• Gaps: 83/630 - (13%)

Human     6 SDRDRGRDRGFGAPRFGGSRAGPLSG--KKFGNPGEK---LVKKKW------NLDELPKFEKNFY 59
            :||.:..:|..|   |.||..|..:|  :.:.|.||:   ....:|      |:|
  Fly   199 NDRWQEPERPAG---FDGSEGGQSAGGNRSYNNRGERGGGGYNSRWKEGGGSNVD---------- 250

Human    60 QEHPDL-ARRTAQEVE---------TYRRSKEITVR--GHNCPKPVLNFYEANFPANVMDVIARQ 112
              :..| ||....|||         .:.:.::|.|.  |.|.|..:.:|.:......:.:.:|..
  Fly   251 --YTKLGARDERLEVELFGVGNTGINFDKYEDIPVEATGQNVPPNITSFDDVQLTEIIRNNVALA 313

Human   113 NFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAI---VHINHQP-------FLERGDG 167
            .:.:||.:|....|:.::|.|::..||||||||.::|:|.:   ..:.|.|       :..|...
  Fly   314 RYDKPTPVQKHAIPIIINGRDLMACAQTGSGKTAAFLVPILNQMYELGHVPPPQSTRQYSRRKQY 378

Human   168 PICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFL 232
            |:.||||||||||.|:.:.|.::....|::...:|||.....|:|:|:||..:.:||||||.|.:
  Fly   379 PLGLVLAPTRELATQIFEEAKKFAYRSRMRPAVLYGGNNTSEQMRELDRGCHLIVATPGRLEDMI 443

Human   233 ECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIR----PDRQTLMWSATWPKEVRQLAEDF 293
            ..||..|....:|||||||||||||||||||:||:|:.    ..|||||:|||:||::::||.||
  Fly   444 TRGKVGLENIRFLVLDEADRMLDMGFEPQIRRIVEQLNMPPTGQRQTLMFSATFPKQIQELASDF 508

Human   294 LKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMS----EKENKTIVFVETKRRC 354
            |.:||.:.:|.:. |.:.||.|.:...::.:|...|:.|:..|..    .|::.|::|||||:..
  Fly   509 LSNYIFLAVGRVG-STSENITQTILWVYEPDKRSYLLDLLSSIRDGPEYTKDSLTLIFVETKKGA 572

Human   355 DELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYP 419
            |.|...:.:...|...||||::|:||:..|..|:.|..|||:||.||:||||:..||.|||:|.|
  Fly   573 DSLEEFLYQCNHPVTSIHGDRTQKEREEALRCFRSGDCPILVATAVAARGLDIPHVKHVINFDLP 637

Human   420 NSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSR 484
            :..|:|:||||||.|....|.|.:||...|....|||:.:|.|..|.|...:..:..|||.|.::
  Fly   638 SDVEEYVHRIGRTGRMGNLGVATSFFNEKNRNICSDLLELLIETKQEIPSFMEDMSSDRGHGGAK 702

Human   485 --GRGGMK------DDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKT--QNGVYSAAN 539
              ||||..      ..|..|.|:|..||            |.|....|..|:.:  ..|.|.:..
  Fly   703 RAGRGGGGRYGGGFGSRDYRQSSGGGGG------------GRSGPPPRSGGSGSGGGGGSYRSNG 755

Human   540 YTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGY-DSTQQYGSNVPN 583
            .:.|.||.|....|.   :..|...|:|...| ..:..:.||.|:
  Fly   756 NSYGKFGGNSGGGGY---YGGGAGGGSYGGSYGGGSASHSSNAPD 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX5	NP_004387.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		10/34 (29%)
		DEAD-like_helicase_N	6..507	CDD:475120	200/549 (36%)
		Q motif	94..122		4/27 (15%)
		DEAD box	248..251		2/2 (100%)
		Transactivation domain	477..614		32/118 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..504		12/34 (35%)
		P68HR	498..532	CDD:429808	8/35 (23%)
		P68HR	551..583	CDD:429808	7/32 (22%)
bel	NP_001262379.1	DEADc_DDX3	275..522	CDD:350809	98/247 (40%)
		SF2_C_DEAD	527..663	CDD:350174	55/135 (41%)