DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DDX5 and CG7878

DIOPT Version :10

Sequence 1:NP_004387.1 Gene:DDX5 / 1655 HGNCID:2746 Length:614 Species:Homo sapiens
Sequence 2:NP_649767.1 Gene:CG7878 / 40959 FlyBaseID:FBgn0037549 Length:703 Species:Drosophila melanogaster


Alignment Length:560 Identity:221/560 - (39%)
Similarity:330/560 - (58%) Gaps:70/560 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     9 DRGRDR------------GFGAPRFGGS--RAGPLSGKKFGNPG--------EKLVK-------K 44
            |||:||            |.|..|:.|:  ...|.|.:...:.|        |.|.|       .
  Fly   159 DRGQDRDNRDHGSNERYDGGGYDRYKGNSYEFNPTSSESNKDNGDLTGIIDWEALNKASIAATAA 223

Human    45 KWNLDELPKFEKNFYQEHPDLARRTAQEVETYR-RSKEITV-------RGHN---CPKPVLNFYE 98
            :|:  :.|...||||:|.|::|..|..|:|..| .:.:|||       .|..   .|.||..|.:
  Fly   224 RWS--KCPPLTKNFYKEAPEVANLTKSEIERIREENNKITVSYVFEPKEGETSPPIPNPVWTFEQ 286

Human    99 --ANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQ-- 159
              |.:| ::::.|.:..|::|:.||:|.||:.|.|.||:|:||||:||||::|||.::|..:|  
  Fly   287 CFAEYP-DMLEEITKMGFSKPSPIQSQAWPILLQGHDMIGIAQTGTGKTLAFLLPGMIHTEYQST 350

Human   160 PFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACR-LKSTCIYGGAPKGPQIRDLERGVEICIA 223
            |...|| |...||||||||||.|::....:|  :.| :|:.|:|||..:..||.|||||.||.|.
  Fly   351 PRGTRG-GANVLVLAPTRELALQIEMEVKKY--SFRGMKAVCVYGGGNRNMQISDLERGAEIIIC 412

Human   224 TPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQ 288
            |||||.|.:.....::...||||||||||||||||||||||::..|||||||:|.|||||..||:
  Fly   413 TPGRLNDLIMANVIDVSTITYLVLDEADRMLDMGFEPQIRKVMLDIRPDRQTIMTSATWPPGVRR 477

Human   289 LAEDFLKDYIHINIGALELSANHNILQIVDVCH-DVEKDEKLIRLMEEIMSEKENKTIVFVETKR 352
            ||:.::|:.|.:.:|:|:|:|.|::.||:.:.. |::|...:...::.:.|  .:|.|:|...|.
  Fly   478 LAQSYMKNPIQVCVGSLDLAATHSVKQIIKLMEDDMDKFNTITSFVKNMSS--TDKIIIFCGRKV 540

Human   353 RCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYD 417
            |.|:|:.::..||:....|||::.|.:|:..:.:.|.|...||:||||||||||:||:..|||||
  Fly   541 RADDLSSELTLDGFMTQCIHGNRDQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYD 605

Human   418 YPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKL------LQLVE 476
            :|::.|:|:||:|||.|:.:.||:.:|||..:.....:||.:|:||.|.:..:|      .:.::
  Fly   606 FPHNIEEYVHRVGRTGRAGRQGTSISFFTREDWAMAKELIEILQEAEQEVPDELHNMARRFKAMK 670

Human   477 DRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDR 516
            |:.:....|.||    |..|:..|:.||      |.|:|:
  Fly   671 DKRAAEGGGFGG----RGGRFGGGRGGG------RRNFDQ 700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DDX5NP_004387.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39 12/51 (24%)
DEAD-like_helicase_N 6..507 CDD:475120 218/549 (40%)
Q motif 94..122 7/29 (24%)
DEAD box 248..251 2/2 (100%)
Transactivation domain 477..614 12/40 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..504 7/26 (27%)
P68HR 498..532 CDD:429808 6/19 (32%)
P68HR 551..583 CDD:429808
CG7878NP_649767.1 KH_1 92..152 CDD:459630
DEAD-like_helicase_N 174..663 CDD:475120 204/496 (41%)
Blue background indicates that the domain is not in the aligned region.

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