Protein Alignment DDX5 and CG10077

DIOPT Version :10

• Sequence 1: NP_004387.1
• Gene: DDX5 / 1655
• HGNCID: 2746
• Length: 614
• Species: Homo sapiens
• Sequence 2: NP_648062.2
• Gene: CG10077 / 38756
• FlyBaseID: FBgn0035720
• Length: 818
• Species: Drosophila melanogaster
• Alignment Length: 592
• Identity: 333/592 - (56%)
• Similarity: 403/592 - (68%)
• Gaps: 42/592 - (7%)

Human    11 GRDRGFGAPR----FGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQ 71
            |...|.|.||    |||..    .|::..|.|..|.|..|:...|..|.||||:....:..||..
  Fly    74 GPSMGPGGPRNQDGFGGQN----GGQRSSNHGAHLPKIVWSEVNLTPFRKNFYKPCDSVLARTVG 134

Human    72 EVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVG 136
            |.||:..|.|||::|...|.|.:.|.|..||..||:.|.:|.|.:||||||||||:|:||.|:||
  Fly   135 ETETFLTSNEITIKGDQVPTPSIEFEEGGFPDYVMNEIRKQGFAKPTAIQAQGWPIAMSGRDLVG 199

Human   137 VAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCI 201
            ||||||||||:|:|||:||||:||.||||||||.||||||||||||:||||.|:.....:::|||
  Fly   200 VAQTGSGKTLAYVLPAVVHINNQPRLERGDGPIALVLAPTRELAQQIQQVAIEFGSNTHVRNTCI 264

Human   202 YGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIV 266
            :||||||.|.|||||||||.||||||||||||.|.|:|:|.|||||||||||||||||||||||:
  Fly   265 FGGAPKGQQARDLERGVEIVIATPGRLIDFLERGTTSLKRCTYLVLDEADRMLDMGFEPQIRKIM 329

Human   267 DQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIR 331
            .|||||||.||||||||||||||||:||.:||.:|||:|.||||||||||||||.:.||..|||:
  Fly   330 QQIRPDRQVLMWSATWPKEVRQLAEEFLNNYIQVNIGSLSLSANHNILQIVDVCDENEKLMKLIK 394

Human   332 LMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILI 396
            |:.:|.:|.|.|||:|||||:|.||:||.:.|.||.|..|||||||||||:||:.|::|:..||:
  Fly   395 LLTDISAENETKTIIFVETKKRVDEITRNISRQGWRACAIHGDKSQQERDFVLSSFRNGRHSILV 459

Human   397 ATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLR 461
            |||||:|||||:|||||||||||::||||:||||||.||..||||||.||.:|..:.:|||.|||
  Fly   460 ATDVAARGLDVDDVKFVINYDYPSNSEDYVHRIGRTGRSNNTGTAYTLFTHSNANKANDLIQVLR 524

Human   462 EANQAINPKLLQLV-----EDRGSGRSRG-RGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSS 520
            ||||.|||||:.:.     ..||.|...| |||.....|:....|...|.|.:|:    :.|..:
  Fly   525 EANQTINPKLMNMAMNGGYNKRGGGMGGGYRGGNGYQGRNPQMGGGYNGGNNYRN----NNGPGA 585

Human   521 LLKRDFGAKTQNGVYSAANYTNGSFG----------SNFVSAGIQTSFRTGNPTGTYQNGYDSTQ 575
            .:.|:             ::..||.|          ::..:.|.|..:| |...|.||......|
  Fly   586 TMNRN-------------SFNGGSAGGPPRFDQKPRTSPPNQGGQGGYR-GQGGGGYQGQQQQQQ 636

Human   576 QYGSNVP 582
            |....||
  Fly   637 QQNGGVP 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX5	NP_004387.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		10/31 (32%)
		DEAD-like_helicase_N	6..507	CDD:475120	315/505 (62%)
		Q motif	94..122		13/27 (48%)
		DEAD box	248..251		2/2 (100%)
		Transactivation domain	477..614		28/117 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..504		9/27 (33%)
		P68HR	498..532	CDD:429808	6/33 (18%)
		P68HR	551..583	CDD:429808	11/32 (34%)
CG10077	NP_648062.2	DEAD-like_helicase_N	49..544	CDD:475120	305/473 (64%)