DRSC/TRiP Functional Genomics Resources

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Protein Alignment DDX5 and CG10333

DIOPT Version :10

Sequence 1:NP_004387.1 Gene:DDX5 / 1655 HGNCID:2746 Length:614 Species:Homo sapiens
Sequence 2:NP_609888.2 Gene:CG10333 / 35112 FlyBaseID:FBgn0032690 Length:822 Species:Drosophila melanogaster


Alignment Length:444 Identity:164/444 - (36%)
Similarity:254/444 - (57%) Gaps:44/444 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    43 KKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMD 107
            |:||:       ::::.::..|  ..|.::...:|....:|::|...|.|:.::.|:.||..::|
  Fly   352 KQKWD-------DRHWSEKEND--EMTERDWRIFREDYNVTIKGGRIPNPIRSWNESGFPKEIID 407

Human   108 VIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLER----GDGP 168
            :|.:..:.|||.||.|..|:.|...|::|||:|||||||::|:|.:..|...|.:||    ..||
  Fly   408 IIDKVGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIPLLSWIQSLPKIERLEDVDQGP 472

Human   169 ICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLE 233
            ..:::|||||||||:::...::.:...:::..:.||..:..|...|..|.||.|||||||||.||
  Fly   473 YAIIMAPTRELAQQIEEETTKFGQPLGIRTVVVVGGLSREEQGFRLRLGCEIVIATPGRLIDVLE 537

Human   234 CGKTNLRRTTYLVLDEADRMLDMGFEPQIRKI-----VDQIRPD--------------------R 273
            .....|.:.||:||||||||:||||||.::||     |..::||                    |
  Fly   538 NRYLVLNQCTYIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDTEEAEDETKLMENFYTKKKYR 602

Human   274 QTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMS 338
            ||:|::||.|..|.:||..:|:....:.||::. .......|||.:..:.:|.:||:    ||:|
  Fly   603 QTVMFTATMPPAVERLARTYLRRPATVYIGSVG-KPTERTEQIVYMMGENDKRKKLM----EILS 662

Human   339 EK-ENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVAS 402
            .| :...|:||..|:..|.|.:.:.:.|:.:..:||.|.|::|::.|...|.|...||:|||||.
  Fly   663 RKIDPPVIIFVNQKKGADVLAKGLEKLGYNSCTLHGGKGQEQREYALAALKSGAKDILVATDVAG 727

Human   403 RGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDL 456
            ||:|::||..|||||...:.|||.||||||.|:.|||.|.:|.|.::.....||
  Fly   728 RGIDIKDVSLVINYDMAKTIEDYTHRIGRTGRAGKTGCAISFVTKDDSALFYDL 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DDX5NP_004387.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
DEAD-like_helicase_N 6..507 CDD:475120 164/444 (37%)
Q motif 94..122 9/27 (33%)
DEAD box 248..251 2/2 (100%)
Transactivation domain 477..614
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..504
P68HR 498..532 CDD:429808
P68HR 551..583 CDD:429808
CG10333NP_609888.2 DUF5401 <66..354 CDD:375164 1/1 (100%)
SrmB 395..783 CDD:440279 154/392 (39%)
Blue background indicates that the domain is not in the aligned region.

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