DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kera and CG18095

DIOPT Version :9

Sequence 1:	NP_032464.1	Gene:	Kera / 16545	MGIID:	1202398	Length:	351	Species:	Mus musculus
Sequence 2:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	275	Identity:	71/275 - (25%)
Similarity:	128/275 - (46%)	Gaps:	33/275 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse    77 LYLENNLIESIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPL 141
            |.|.:|::..:..|.||...||:.::|..|:|:.  ||..:...|..|..|:|..|:|..:....
  Fly   116 LDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQ--IENDSFDGLSHLKHLYLNGNQLAHIDGSF 178

Mouse   142 PRSLEQ---LQLARNKVSRIPQGTFSNLENLTLLDLQHNKLLDNAFQRDTFKGLKNLMQLNMAKN 203
            .|.|.:   |.|..|::..|...:|.:..:|..|.|..|.|  ::.|..:.:||..|:.||::.|
  Fly   179 FRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLL--SSLQFLSQRGLARLVHLNLSSN 241

Mouse   204 ALRNMPPRLPANTMQ---LFLDNNSIEGIPENYFNVIPKVAFLRLNHN---KLSDAGLPSRGFDV 262
            .|:.:.|.:.:...:   |.|..|:|..:.:...:.:..:..|.::||   |:.|..|.|    :
  Fly   242 LLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDS----L 302

Mouse   263 SSILDLQLSYNQLTNFP----RINANLQHLHLDHNKIKNVNMSVICPTTLRAEQDAFIHGPQLSY 323
            .::|.|.:|:|.||..|    ..|..|:.:.|.:|||:.::..::            .:...|.|
  Fly   303 IALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMM------------FNQNHLRY 355

Mouse   324 LRLDGNEIKPPIPID 338
            ::|.||.|.....:|
  Fly   356 IKLSGNAISDAAFLD 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kera	NP_032464.1	PRK15370	16..>298	CDD:185268	64/233 (27%)
		LRR 1	73..94		5/16 (31%)
		leucine-rich repeat	74..97	CDD:275380	6/19 (32%)
		LRR 2	97..118		7/20 (35%)
		leucine-rich repeat	98..123	CDD:275380	7/24 (29%)
		LRR 3	123..143		5/19 (26%)
		leucine-rich repeat	124..144	CDD:275380	5/19 (26%)
		LRR 4	144..165		6/23 (26%)
		leucine-rich repeat	145..168	CDD:275380	6/25 (24%)
		LRR 5	168..181		5/12 (42%)
		leucine-rich repeat	169..194	CDD:275380	8/24 (33%)
		LRR 6	194..214		6/19 (32%)
		leucine-rich repeat	195..218	CDD:275380	6/22 (27%)
		LRR 7	215..236		4/23 (17%)
		leucine-rich repeat	219..239	CDD:275380	4/19 (21%)
		LRR 8	239..259		7/22 (32%)
		leucine-rich repeat	240..265	CDD:275380	7/27 (26%)
		LRR 9	264..283		7/22 (32%)
		LRR_8	268..331	CDD:338972	17/66 (26%)
		LRR 10	284..305		5/20 (25%)
		leucine-rich repeat	285..320	CDD:275380	5/34 (15%)
		leucine-rich repeat	321..342	CDD:275380	7/18 (39%)
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380
		LRR_8	64..123	CDD:290566	3/6 (50%)
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380	6/19 (32%)
		LRR_RI	115..384	CDD:238064	71/275 (26%)
		LRR_8	135..195	CDD:290566	18/61 (30%)
		leucine-rich repeat	137..160	CDD:275380	7/24 (29%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		LRR_8	184..243	CDD:290566	17/60 (28%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..232	CDD:275380	8/24 (33%)
		LRR_8	232..289	CDD:290566	11/56 (20%)
		leucine-rich repeat	233..256	CDD:275380	6/22 (27%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		LRR_8	280..339	CDD:290566	18/62 (29%)
		leucine-rich repeat	281..304	CDD:275380	7/26 (27%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100