DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdr and drpr

DIOPT Version :9

Sequence 1:	NP_034742.2	Gene:	Kdr / 16542	MGIID:	96683	Length:	1345	Species:	Mus musculus
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	218	Identity:	47/218 - (21%)
Similarity:	67/218 - (30%)	Gaps:	88/218 - (40%)

- Green bases have known domain annotations that are detailed below.

Mouse   590 SVHMGESLTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSA------------ 642
            |.:.||:...||:.|           :||:.|           .|.|:.:|||
  Fly   569 SGYYGENCDKVCRCL-----------NNSSCD-----------PDSGNCICSAGWTGADCAEPCP 611

Mouse   643 ---QDKKTKKRHCLVKQLIILERMAPMITGNLENQTTTIGETIEVTCPAS--------------G 690
               ...:.|:| |  .:::...:....|||.:..:|..||.|.|..|||.              |
  Fly   612 PGFYGMECKER-C--PEILHGNKSCDHITGEILCRTGYIGLTCEHPCPAGLYGPGCKLKCNCEHG 673

Mouse   691 NPTPHIT--------WFKD--NETLVEDS---GIVLRDGNRNLTIRRVRKEDG------------ 730
            ....|:|        |...  ||:...|:   |...|  .|.:..:..||.||
  Fly   674 GECNHVTGQCQCLPGWTGSNCNESCPTDTYGQGCAQR--CRCVHHKVCRKADGMCICETGWSGTR 736

Mouse   731 -------GLYTCQACNVLGCARA 746
                   |.|.....|...|..|
  Fly   737 CDEVCPEGFYGEHCMNTCACPSA 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdr	NP_034742.2	Ig_3	31..105	CDD:404760
		Ig	226..327	CDD:416386
		Ig strand A	226..230	CDD:409353
		Ig strand A'	236..240	CDD:409353
		Ig strand B	242..251	CDD:409353
		Ig strand C	258..263	CDD:409353
		Ig strand C'	266..268	CDD:409353
		Ig strand D	272..280	CDD:409353
		Ig strand E	288..296	CDD:409353
		Ig strand F	306..312	CDD:409353
		Ig strand G	317..323	CDD:409353
		Ig	331..419	CDD:416386
		Ig strand A	331..334	CDD:409353
		Ig strand A'	341..345	CDD:409353
		Ig strand B	347..358	CDD:409353
		Ig strand C	362..368	CDD:409353
		Ig strand C'	370..373	CDD:409353
		Ig strand D	378..381	CDD:409353
		Ig strand E	383..388	CDD:409353
		Ig strand F	396..404	CDD:409353
		Ig strand G	410..419	CDD:409353
		Ig_3	549..643	CDD:404760	14/67 (21%)
		I-set	665..742	CDD:400151	28/122 (23%)
		Ig strand B	682..686	CDD:409353	1/3 (33%)
		Ig strand C	695..699	CDD:409353	2/11 (18%)
		Ig strand E	718..722	CDD:409353	1/3 (33%)
		Ig strand F	732..737	CDD:409353	1/4 (25%)
		VEGFR-2_TMD	757..791	CDD:375470
		PTKc_VEGFR2	824..1165	CDD:270681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1272..1316
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925	14/58 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900